Q8LCG7
Gene name |
NFYC2 (HAP5B, At1g56170, F14G9.21, T6H22.3) |
Protein name |
Nuclear transcription factor Y subunit C-2 |
Names |
AtNF-YC-2, Transcriptional activator HAP5B |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G56170 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8LCG7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8LCG7-F1 | Predicted | AlphaFoldDB |
11 variants for Q8LCG7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH04974710 | 25 | Q>H | No | 1000Genomes | |
| tmp_1_21025199_C_G | 28 | P>A | No | 1000Genomes | |
| ENSVATH04974711 | 35 | M>T | No | 1000Genomes | |
| tmp_1_21025224_C_A | 36 | A>E | No | 1000Genomes | |
| tmp_1_21025256_C_G | 47 | H>D | No | 1000Genomes | |
| ENSVATH01377084 | 50 | Q>L | No | 1000Genomes | |
| tmp_1_21025337_A_G | 74 | N>D | No | 1000Genomes | |
| tmp_1_21025370_A_G | 85 | I>V | No | 1000Genomes | |
| ENSVATH13591480 | 152 | I>V | No | 1000Genomes | |
| ENSVATH04974713 | 171 | S>P | No | 1000Genomes | |
| tmp_1_21025656_A_T | 180 | Y>F | No | 1000Genomes |
No associated diseases with Q8LCG7
1 regional properties for Q8LCG7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Histone H2A/H2B/H3 | 44 - 139 | IPR007125 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| CCAAT-binding factor complex | A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription activator activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. |
| DNA-binding transcription factor activity | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| transcription cis-regulatory region binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEQSEEGQQQ | QQQGVMDYVP | PHAYQSGPVN | AASHMAFQQA | HHFHHHHQQQ | QQQQLQMFWA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NQMQEIEHTT | DFKNHTLPLA | RIKKIMKADE | DVRMISAEAP | VIFAKACEMF | ILELTLRAWI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HTEENKRRTL | QKNDIAAAIS | RTDVFDFLVD | IIPRDELKEE | GLGVTKGTIP | SVVGSPPYYY |
| 190 | |||||
| LQQQGMMQHW | PQEQHPDES |