Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q8L4B2

Entry ID Method Resolution Chain Position Source
AF-Q8L4B2-F1 Predicted AlphaFoldDB

5 variants for Q8L4B2

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_2883287_G_T 48 Q>H No 1000Genomes
ENSVATH04542227 67 F>I No 1000Genomes
tmp_1_2883667_C_A 175 P>Q No 1000Genomes
ENSVATH04542229 175 P>S No 1000Genomes
ENSVATH04542230 218 M>V No 1000Genomes

No associated diseases with Q8L4B2

1 regional properties for Q8L4B2

Type Name Position InterPro Accession
domain Histone H2A/H2B/H3 46 - 143 IPR007125

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
transcription cis-regulatory region binding Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

5 GO annotations of biological process

Name Definition
abscisic acid-activated signaling pathway The series of molecular signals generated by the binding of the plant hormone abscisic acid (ABA) to a receptor, and ending with modulation of a cellular process, e.g. transcription.
gibberellic acid mediated signaling pathway The series of molecular signals mediated by the detection of gibberellic acid.
positive regulation of photomorphogenesis Any process that activates or increases the frequency, rate or extent of photomorphogenesis.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of seed germination Any process that modulates the frequency, rate or extent of seed germination.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8LCG7 NFYC2 Nuclear transcription factor Y subunit C-2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZVL3 NFYC3 Nuclear transcription factor Y subunit C-3 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MDQQDHGQSG AMNYGTNPYQ TNPMSTTAAT VAGGAAQPGQ LAFHQIHQQQ QQQQLAQQLQ
70 80 90 100 110 120
AFWENQFKEI EKTTDFKNHS LPLARIKKIM KADEDVRMIS AEAPVVFARA CEMFILELTL
130 140 150 160 170 180
RSWNHTEENK RRTLQKNDIA AAVTRTDIFD FLVDIVPRED LRDEVLGSIP RGTVPEAAAA
190 200 210 220 230
GYPYGYLPAG TAPIGNPGMV MGNPGGAYPP NPYMGQPMWQ QQAPDQPDQE N