Q8L7L1
PR
Gene name |
SPHK1 (At4g21540, F18E5.160) |
Protein name |
Sphingosine kinase 1 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G21540 |
EC number |
2.7.1.91: Phosphotransferases with an alcohol group as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8L7L1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8L7L1-F1 | Predicted | AlphaFoldDB |
51 variants for Q8L7L1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_11459622_C_G | 5 | P>R | No | 1000Genomes | |
| ENSVATH14273058 | 35 | A>D | No | 1000Genomes | |
| ENSVATH06744901 | 38 | E>G | No | 1000Genomes | |
| tmp_4_11459754_C_T | 49 | S>L | No | 1000Genomes | |
| tmp_4_11459763_C_G | 52 | A>G | No | 1000Genomes | |
| ENSVATH06744902 | 61 | E>V | No | 1000Genomes | |
| tmp_4_11459799_A_G | 64 | K>R | No | 1000Genomes | |
| ENSVATH14273059 | 68 | K>N | No | 1000Genomes | |
| ENSVATH06744903 | 73 | K>R | No | 1000Genomes | |
| ENSVATH12116471 | 74 | G>A | No | 1000Genomes | |
| ENSVATH00528814 | 75 | G>E | No | 1000Genomes | |
| tmp_4_11459871_G_A | 88 | R>K | No | 1000Genomes | |
| ENSVATH02901560 | 95 | P>H | No | 1000Genomes | |
| ENSVATH12116472 | 96 | L>P | No | 1000Genomes | |
| ENSVATH06744904 | 111 | H>L | No | 1000Genomes | |
| tmp_4_11460050_C_G | 118 | P>A | No | 1000Genomes | |
| ENSVATH06744909 | 122 | L>F | No | 1000Genomes | |
| tmp_4_11460138_A_C | 147 | E>A | No | 1000Genomes | |
| ENSVATH06744912 | 147 | E>D | No | 1000Genomes | |
| ENSVATH06744913 | 156 | Q>E | No | 1000Genomes | |
| ENSVATH06744919 | 167 | I>V | No | 1000Genomes | |
| ENSVATH06744920 | 172 | D>E | No | 1000Genomes | |
| tmp_4_11460301_T_C | 176 | Y>H | No | 1000Genomes | |
| tmp_4_11460334_A_G | 187 | I>V | No | 1000Genomes | |
| ENSVATH06744922 | 189 | V>A | No | 1000Genomes | |
| ENSVATH14273061 | 189 | V>I | No | 1000Genomes | |
| ENSVATH06744943 | 196 | L>F | No | 1000Genomes | |
| tmp_4_11460910_G_A | 217 | G>D | No | 1000Genomes | |
| tmp_4_11460942_G_C | 228 | V>L | No | 1000Genomes | |
| tmp_4_11460948_C_T | 230 | L>F | No | 1000Genomes | |
| tmp_4_11461140_C_A | 262 | F>L | No | 1000Genomes | |
| ENSVATH12116564 | 319 | Y>C | No | 1000Genomes | |
| tmp_4_11461633_G_A | 322 | R>Q | No | 1000Genomes | |
| ENSVATH00528823 | 324 | S>G | No | 1000Genomes | |
| tmp_4_11461650_G_A | 328 | D>N | No | 1000Genomes | |
| ENSVATH06744975 | 331 | P>S | No | 1000Genomes | |
| ENSVATH02901571 | 332 | S>F | No | 1000Genomes | |
| ENSVATH12116625 | 336 | K>E | No | 1000Genomes | |
| ENSVATH14273078 | 337 | T>S | No | 1000Genomes | |
| tmp_4_11461687_A_G | 340 | Y>C | No | 1000Genomes | |
| tmp_4_11461702_G_T | 345 | S>I | No | 1000Genomes | |
| ENSVATH12116626 | 354 | E>K | No | 1000Genomes | |
| ENSVATH06744976 | 357 | G>S | No | 1000Genomes | |
| tmp_4_11461753_T_C | 362 | V>A | No | 1000Genomes | |
| ENSVATH00528824 | 398 | L>V | No | 1000Genomes | |
| tmp_4_11462170_G_T | 424 | K>N | No | 1000Genomes | |
| ENSVATH06744992 | 451 | A>E | No | 1000Genomes | |
| tmp_4_11462272_A_T | 458 | K>N | No | 1000Genomes | |
| tmp_4_11462284_G_C | 462 | K>N | No | 1000Genomes | |
| tmp_4_11462300_G_C | 468 | D>H | No | 1000Genomes | |
| ENSVATH15072273 | 486 | E>Y | No | 1000Genomes |
No associated diseases with Q8L7L1
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.1.91 | Phosphotransferases with an alcohol group as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| plant-type vacuole | A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana. |
| plant-type vacuole membrane | The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this component is found in Arabidopsis thaliana. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| D-erythro-sphingosine kinase activity | Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP. |
| lipid kinase activity | Catalysis of the phosphorylation of a simple or complex lipid. |
| sphinganine kinase activity | Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to abscisic acid stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| response to abscisic acid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus. |
| seed germination | The physiological and developmental changes that occur in a seed commencing with water uptake (imbibition) and terminating with the elongation of the embryonic axis. |
| sphingolipid metabolic process | The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). |
| sphingosine biosynthetic process | The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues. |
2 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDRQPEREND | ELPSPAIISD | RVLVNGVVTP | LTLTAEGELR | STESGRRKST | LAKEILSFVV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EGNKVRVKTL | VEKGGGICCR | GSAGDYARND | FVFEPLSDES | RKLWSDKFHQ | HLVSLGRPKK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LLVFVNPFGG | KKTARKIFQE | EVKPLFEDAN | IQLEIQETKY | QLHAKEIVRS | MDVSKYDGIV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CVSGDGILVE | VVNGLLERED | WKTAIKLPIG | MVPAGSGNGM | IKSLLEPVGL | PCSATSATIS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IIRGRTRSLD | VATISQGTTK | FFSVLMLAWG | LVADIDIESE | KFRWMGSARF | DIYGLQRIIC |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LRQYHGRILF | VPAPGFESYG | QRASCSIDKE | PSGSDKTLVY | QGPDSKLENL | DWREMKGPFV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SVWLHNVPWG | AENTLAAPDA | KFSDGFLDLI | VMKDCPKLAL | LSLMTKLSDG | THVQSPYASY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LKVKAFVLEP | GARIDEPDKE | GIIDSDGEVL | ARGRKSYKCD | QKALMSYDKL | QISVDQGLAT |
| LFSPE |