Q06147

PR
Gene name
LCB5 (YLR260W)
Protein name
Sphingoid long chain base kinase 5
Names
LCB kinase 5, Sphinganine kinase 5
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YLR260W
EC number
2.7.1.91: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-293 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q06147

Entry ID Method Resolution Chain Position Source
AF-Q06147-F1 Predicted AlphaFoldDB

6 variants for Q06147

Variant ID(s) Position Change Description Diseaes Association Provenance
s12-665955 37 P>L No SGRP
s12-666392 183 E>Q No SGRP
s12-666675 277 P>L No SGRP
s12-667341 499 D>G No SGRP
s12-667461 539 Q>R No SGRP
s12-667556 571 G>S No SGRP

No associated diseases with Q06147

5 regional properties for Q06147

Type Name Position InterPro Accession
domain Mononegavirales RNA-directed RNA polymerase catalytic domain 35 - 1083 IPR014023
domain Mononegavirus L protein 2-O-ribose methyltransferase 1674 - 1871 IPR025786
domain Mononegavirales mRNA-capping domain V 1093 - 1326 IPR026890
domain RNA-directed RNA polymerase L methyltransferase domain, rhabdovirus 1361 - 2051 IPR039530
domain RNA-directed RNA polymerase L, C-terminal 1189 - 2093 IPR039736

Functions

Description
EC Number 2.7.1.91 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Golgi apparatus membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
D-erythro-sphingosine kinase activity Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP.
lipid kinase activity Catalysis of the phosphorylation of a simple or complex lipid.
sphinganine kinase activity Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate.

5 GO annotations of biological process

Name Definition
calcium-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
response to heat Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
sphingolipid metabolic process The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
sphingosine biosynthetic process The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q12246 LCB4 Sphingoid long chain base kinase 4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q8L7L1 SPHK1 Sphingosine kinase 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MTLKPSKRRK GRSRHSRKKQ ITSAILTEEG IMIKAKPSSP YTYANRMADK RSRSSIDNIS
70 80 90 100 110 120
RTSFQSNISR TSFQSNSDNN SIFETASLIS CVTCLSDTDT IDRSETSTTD TSKDDLSANP
130 140 150 160 170 180
KLHYPSVNGQ LPANTVIPYG RILDARYIEK EPLHYYDANS SPSSPLSSSM SNISEKCDLD
190 200 210 220 230 240
ELESSQKKER KGNSLSRGSN SSSSLLTSRS PFTKLVEVIF ARPRRHDVVP KRVSLYIDYK
250 260 270 280 290 300
PHSSSHLKEE DDLVEEILKR SYKNTRRNKS IFVIINPFGG KGKAKKLFMT KAKPLLLASR
310 320 330 340 350 360
CSIEVVYTKY PGHAIEIARE MDIDKYDTIA CASGDGIPHE VINGLYQRPD HVKAFNNIAI
370 380 390 400 410 420
TEIPCGSGNA MSVSCHWTNN PSYSTLCLIK SIETRIDLMC CSQPSYAREH PKLSFLSQTY
430 440 450 460 470 480
GLIAETDINT EFIRWMGPAR FELGVAFNII QKKKYPCEIY VKYAAKSKNE LKNHYLEHKN
490 500 510 520 530 540
KGSLEFQHIT MNKDNEDCDN YNYENEYETE NEDEDEDADA DDEDSHLISR DLADSSADQI
550 560 570 580 590 600
KEEDFKIKYP LDEGIPSDWE RLDPNISNNL GIFYTGKMPY VAADTKFFPA ALPSDGTMDM
610 620 630 640 650 660
VITDARTSLT RMAPILLGLD KGSHVLQPEV LHSKILAYKI IPKLGNGLFS VDGEKFPLEP
670 680
LQVEIMPRLC KTLLRNGRYV DTDFDSM