Q8K4K7
Gene name |
Abra |
Protein name |
Actin-binding Rho-activating protein |
Names |
MS1, Striated muscle activator of Rho-dependent signaling, STARS |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:286965 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q8K4K7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2KRH | NMR | - | A | 295-375 | PDB |
| AF-Q8K4K7-F1 | Predicted | AlphaFoldDB |
1 variants for Q8K4K7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs197967781 | 163 | E>K | No | EVA |
No associated diseases with Q8K4K7
1 regional properties for Q8K4K7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Costars domain | 298 - 374 | IPR027817 |
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
| myofibril | The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| sarcomere | The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of DNA-binding transcription factor activity | Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| positive regulation of Rho protein signal transduction | Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| protein import into nucleus | The directed movement of a protein from the cytoplasm to the nucleus. |
| transcription by RNA polymerase II | The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAPGETEREA | GPAKSALQKV | RRATLVINLA | RGWQQWANEN | STRQAQEPAG | WLPGATQDLP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HTPKEPGPRQ | HAPKPPSPKP | DGDREGRGSE | EATEVSHIKR | KEVTRTVVSK | AYERGGDVNY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LSHRYEHDGG | VSEAVQPDND | IDRILLSHDS | PTRRRKCTNL | VSELTKGWKV | MEQEEPKWKS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DSIDTEDSGY | GGDMEERPEQ | DVAQVAAARI | KRPLHSQANR | YSETLNCKAH | RKYSQVDNLK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GRWQQWADEH | IQSQKLNPFS | DEFDYDLAMS | TRLHKGDEGY | GRPKEGSKTA | ERAKRAEEHI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YREIMELCFV | IRTMARHRRD | GKIQVTFGEL | FDRYVRISDK | VVGILMRARK | HGLVHFEGEM |
| 370 | |||||
| LWQGKDDHVV | ITLLE |