AiPD: Autoinhibited Protein Database

Gene name	Abra
Protein name	Actin-binding Rho-activating protein
Names	Striated muscle activator of Rho-dependent signaling, STARS
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:223513
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-324 (Predicted disordered autoinhibitory region) PR

1-324 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8BUZ1-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389330959	9	E>*	No	EVA
rs3389360824	42	T>S	No	EVA
rs3389355764	51	W>*	No	EVA
rs31781421	59	L>V	No	EVA
rs33213658	62	A>T	No	EVA
rs3389321057	78	P>S	No	EVA
rs3389360850	85	E>*	No	EVA
rs3389369907	87	Q>H	No	EVA
rs3389369866	113	E>VSDG*	No	EVA
rs3389330981	114	R>K	No	EVA
rs3389369871	169	K>*	No	EVA
rs3389353568	169	K>R	No	EVA
rs3389311039	172	E>D	No	EVA
rs3389321047	172	E>V	No	EVA
rs235566361	173	Q>E	No	EVA
rs235566361	173	Q>K	No	EVA
rs3389360586	174	E>V	No	EVA
rs3389353831	176	P>A	No	EVA
rs3389311113	176	P>R	No	EVA
rs3405988699	177	T>M	No	EVA
rs3389357322	178	W>G	No	EVA
rs3389369894	186	E>*	No	EVA
rs3389364828	187	D>N	No	EVA
rs3389311075	202	A>E	No	EVA
rs3389311069	204	P>H	No	EVA
rs32216836	215	L>H	No	EVA
rs49553827	224	T>P	No	EVA
rs3406359816	271	T>P	No	EVA
rs47743747	374	L>V	No	EVA

Type	Name	Position	InterPro Accession
domain	Costars domain	298 - 374	IPR027817

		Description
EC Number
Subcellular Localization	Cytoplasm, myofibril, sarcomere Cytoplasm, cytoskeleton	Localized to the I-band of the sarcomere and to a lesser extent to the sarcomeric structure between Z-lines
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
actin cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
myofibril	The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
sarcomere	The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.

Name	Definition
actin binding	Binding to monomeric or multimeric forms of actin, including actin filaments.

Name	Definition
positive regulation of DNA-binding transcription factor activity	Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
positive regulation of DNA-templated transcription	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of Rho protein signal transduction	Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
protein import into nucleus	The directed movement of a protein from the cytoplasm to the nucleus.
transcription by RNA polymerase II	The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8N0Z2	ABRA	Actin-binding Rho-activating protein	Homo sapiens (Human)	PR
B5SNZ6	ABRA	Actin-binding Rho-activating protein	Sus scrofa (Pig)	PR
Q8K4K7	Abra	Actin-binding Rho-activating protein	Rattus norvegicus (Rat)	PR