B5SNZ6

PR
Gene name
ABRA
Protein name
Actin-binding Rho-activating protein
Names
Striated muscle activator of Rho-dependent signaling, STARS
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:100154546
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-334 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B5SNZ6

Entry ID Method Resolution Chain Position Source
AF-B5SNZ6-F1 Predicted AlphaFoldDB

No variants for B5SNZ6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B5SNZ6

No associated diseases with B5SNZ6

1 regional properties for B5SNZ6

Type Name Position InterPro Accession
domain Costars domain 307 - 383 IPR027817

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, myofibril, sarcomere
  • Cytoplasm, cytoskeleton
  • Localized to the I-band of the sarcomere and to a lesser extent to the sarcomeric structure between Z-lines
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
sarcomere The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.

1 GO annotations of molecular function

Name Definition
actin binding Binding to monomeric or multimeric forms of actin, including actin filaments.

2 GO annotations of biological process

Name Definition
positive regulation of Rho protein signal transduction Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8N0Z2 ABRA Actin-binding Rho-activating protein Homo sapiens (Human) PR
Q8BUZ1 Abra Actin-binding Rho-activating protein Mus musculus (Mouse) PR
Q8K4K7 Abra Actin-binding Rho-activating protein Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MARGEKGRGE GPAKSALRKV RTATLVINLA RGWQQWANEN STRQAQEPTG WMPGGARESD
70 80 90 100 110 120
QPSGPVIHPT THQKVQSAPK SPSPKPGGYG AGQSSEGATE VSPIKRKEVT KTIVSKAYER
130 140 150 160 170 180
GGDVSHLSHR YEKDGDEPEP EQPESDIDRL LRSHGSPTRR RKCANLVSEL TKGWKEMEQE
190 200 210 220 230 240
EQEELKCRSD SIDTEDSGYG GETEERPEQD GEQVAIARIK RPLPSQANRF TEKLNCKAQR
250 260 270 280 290 300
KYSQVGHLKG RWQQWADEHI QSQKLNPFSD EFDYELAMST RLHKGDEGYG RPKEGTRTAE
310 320 330 340 350 360
RAKRAEEHIY REIMDMCFII RTMAHPRRDG KIQVTFGDLF DRYVRISDKV VGILMRARKH
370 380
GLVDFEGEML WQGRDDHVVI TLLK