Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8K3E9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8K3E9-F1 | Predicted | AlphaFoldDB |
No variants for Q8K3E9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8K3E9 | |||||
No associated diseases with Q8K3E9
3 regional properties for Q8K3E9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Homeobox domain | 37 - 93 | IPR001356-1 |
| domain | Homeobox domain | 323 - 387 | IPR001356-2 |
| domain | Homez, homeobox domain | 420 - 476 | IPR024578 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q80W88 | Homez | Homeobox and leucine zipper protein Homez | Mus musculus (Mouse) | PR |
| Q5U2R5 | Ppp1r3c | Protein phosphatase 1 regulatory subunit 3C | Rattus norvegicus (Rat) | PR |
| Q6P950 | ppp1r3cb | Protein phosphatase 1 regulatory subunit 3C-B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSPNKDSSSL | NSSGAGLVCL | PPVSEELQLV | WTQAVQTSEL | DGNEHLLQAF | SYFPYPSLAD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IALLCLRHGL | QMEKVKTWFM | AQRLRCGISW | SSEEIEETRA | RVVYHRDQLL | FKSLLSFTHH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AVRPPQEMPP | VTPPEQVALG | LRPLALSEPT | QMKGLKVEPE | EPFQVSQLPL | NHQKVKEPLM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MGSRTLNHQS | DCQDLQISGL | SKEQAGGGPD | QSCGGGTASW | NHSIAVHQPD | KSPLISLLDN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SCKEESEPSG | TPPSSSASSP | FQVLANGTTA | TPKPLQPLGY | IPQSFSPSEQ | ALSPQVEPLW |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SQRLRNNSVP | SRVGPTEYLS | PDMQHQRKTK | RKTKEQLAIL | KSFFLQCQWA | RREDYHKLEQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ITGLPRPEII | QWFGDTRYAL | KHGQLKWFRD | NAVLGTPSFQ | DPAISTSSTR | SLKEWAKTPP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LPAPPPPPDI | RPLERYWAAH | QQLQEADILK | LSQASRLSTQ | QVLDWFDSRL | PKPAEVVVCL |
| 490 | 500 | 510 | |||
| DEEEEEEDEE | LPEDGEEEEE | EEEEEDDDVI | IRD |