Q80W88
Gene name |
Homez (Kiaa1443) |
Protein name |
Homeobox and leucine zipper protein Homez |
Names |
Homeodomain leucine zipper-containing factor |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:239099 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q80W88
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q80W88-F1 | Predicted | AlphaFoldDB |
No variants for Q80W88
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q80W88 | |||||
No associated diseases with Q80W88
3 regional properties for Q80W88
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Homeobox domain | 61 - 117 | IPR001356-1 |
| domain | Homeobox domain | 348 - 412 | IPR001356-2 |
| domain | Homez, homeobox domain | 445 - 501 | IPR024578 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5U2R5 | Ppp1r3c | Protein phosphatase 1 regulatory subunit 3C | Rattus norvegicus (Rat) | PR |
| Q8K3E9 | Homez | Homeobox and leucine zipper protein Homez | Rattus norvegicus (Rat) | PR |
| Q6P950 | ppp1r3cb | Protein phosphatase 1 regulatory subunit 3C-B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLGHRLLPSL | DFPAVSEGYK | PEHDMSPNKD | ASSLNSSAAG | LVCLPPVSEE | LQLVWTQAIQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TSELDGNEHL | LQAFSYFPYP | SLADIALLCL | RHGLQMEKVK | TWFMAQRLRC | GISWSSEEIE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ETRARVVYHR | DQLLFKSLLS | FTQQSVRPPQ | ERPPVLRPEQ | VALGLSPLAP | SEQPTHMKGL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KVEPEEPSQV | SQLPLNHQNA | KEPLMMGSRT | FSHQSDCQDL | QISGLSKEQA | GRGPDQSCGK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TASWNHFTAV | HQPDKPASVS | LLDNSCKEES | EPSGIPPSSS | TSSPSFQALA | NGTTATPKPL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QPLGCISQSL | SPSKKALSPQ | VEPLWPQRLW | NNSEPNSAGP | TEYLSPDMQH | QRKTKRKTKE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QLAILKSFFL | QCQWARREDY | HKLEQITGLP | RPEIIQWFGD | TRYALKHGQL | KWFRDNAVLG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TPSFQDPAIP | TPSTRSLKEW | AKTPPLPAPP | PPPDIRPLEK | YWAAHQQLQE | ADILKLSQAS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RLSTQQVLDW | FDSRLPKPAE | VVVCLDEEDE | EDEEDELPED | GEEEEEEEED | DDDGDDDVII |
| WD |