Q8K2V6
Gene name |
Ipo11 (Ranbp11) |
Protein name |
Importin-11 |
Names |
Imp11, Ran-binding protein 11, RanBP11 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:76582 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8K2V6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8K2V6-F1 | Predicted | AlphaFoldDB |
30 variants for Q8K2V6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389299929 | 5 | S>N | No | EVA | |
| rs3404671519 | 30 | E>K | No | EVA | |
| rs3403852883 | 35 | W>G | No | EVA | |
| rs3389295885 | 37 | T>K | No | EVA | |
| rs3389309785 | 74 | W>G | No | EVA | |
| rs3389309706 | 189 | T>I | No | EVA | |
| rs3389305019 | 249 | F>Y | No | EVA | |
| rs3404615420 | 303 | V>L | No | EVA | |
| rs3389318684 | 343 | S>T | No | EVA | |
| rs3389309713 | 354 | M>L | No | EVA | |
| rs3389318721 | 384 | W>R | No | EVA | |
| rs3389276512 | 391 | F>L | No | EVA | |
| rs3389303683 | 452 | A>T | No | EVA | |
| rs3389268209 | 502 | Q>R | No | EVA | |
| rs3404703326 | 519 | A>SYRLLHTAWVSSQT* | No | EVA | |
| rs3404703326 | 520 | I>S | No | EVA | |
| rs3389300004 | 572 | T>S | No | EVA | |
| rs3404593704 | 590 | R>G | No | EVA | |
| rs3404525868 | 631 | V>D | No | EVA | |
| rs3389314294 | 657 | Q>* | No | EVA | |
| rs3389230587 | 674 | T>I | No | EVA | |
| rs3403166462 | 756 | L>H | No | EVA | |
| rs3404610909 | 762 | L>I | No | EVA | |
| rs3389300002 | 762 | L>S | No | EVA | |
| rs3389276585 | 851 | A>T | No | EVA | |
| rs3389230561 | 896 | L>M | No | EVA | |
| rs3389285308 | 903 | P>S | No | EVA | |
| rs3389303510 | 946 | E>D | No | EVA | |
| rs3389309698 | 961 | D>V | No | EVA | |
| rs3389285256 | 971 | F>V | No | EVA |
No associated diseases with Q8K2V6
1 regional properties for Q8K2V6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Importin-beta, N-terminal domain | 28 - 100 | IPR001494 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| nuclear import signal receptor activity | Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein. |
| small GTPase binding | Binding to a small monomeric GTPase. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein import into nucleus | The directed movement of a protein from the cytoplasm to the nucleus. |
| ribosomal protein import into nucleus | The directed movement of a ribosomal protein from the cytoplasm into the nucleus, across the nuclear membrane. At least some ribosomal proteins, including rpl12, uses the importin 11 pathway as a major route into the nucleus. |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDLNSASSVV | LQVLTQATSQ | DTAVLKPAEE | QLKQWETQPG | FYSVLLNIFT | NHTLDINVRW |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LAVLYFKHGI | DRYWRRVAPH | ALSEEEKSTL | RAGLITNFNE | PINQIATQIA | VLIAKVARLD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CPRQWPELIP | TLVESVKVQD | DLRQHRALLT | FYHVTKTLAS | KRLAADRKLF | YDLASGIYNF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ACSLWNHHTD | TFLQHVSSGN | EAAVLSSLER | TLLSLKVLRK | LTVNGFVEPH | KNMEVMGFLH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GIFERLKQFL | ECSRSIGTDN | VCRDRLEKTI | ILFTKVLLDF | LDQHPISFTP | LIQRSLEFSV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SYVFTEVGEG | VTFERFIVQC | MNLIKMIVKN | YAYKPSKNFE | DSSPETLEAH | KIKMAFFTYP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TLTEICRRLV | SHYFLLTEEE | LTMWEEDPEG | FTVEETGGDS | WKYSLRPCTE | VLFIDIFHEY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NQTLTPVLLE | MMQTLEGPTN | VEDMNALLIK | DAVYNAVGLA | AFELFDSVDF | DQWFKTQLLP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ELQVSHNRYK | PLRRRVIWLI | GQWISVKFKS | DLRPMLYEAI | CNLLQDQDLV | VRIETATTLK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LTVDDFEFRT | DQFLPYLETM | FTLLFQLLQQ | VTECDTKMHV | LHVLSCVIER | VNVQIRPYVG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| CLVQYLPLLW | KQSEEHNMLR | CAILTTLIHL | VQGLGADSKN | LYPFLLPVIQ | LSTDVSQPPH |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VYLLEDGLEL | WLVTLENSPC | VTPELLRIFQ | NMSPLLELSS | ENLRTCFKII | NGYIFLSSTE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| FLQTYAAGLC | QSFYELLPEI | TTEGQVQVLK | VVENALKVNP | VLGPQMFQRI | LPCVFRGVIE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| GERYPVVMSI | YLAVMGRVLL | QNTSFFSSLL | NEMGHEFNQE | MDQLLGNVIE | MWVDRMDNIT |
| 850 | 860 | 870 | 880 | 890 | 900 |
| QPERKKLSAL | ALLSLLPSDN | SVIQDKFCGI | INISVEALHD | VMTEDPETRT | YKDCMLMSQH |
| 910 | 920 | 930 | 940 | 950 | 960 |
| EEPKVTEDEE | PPTEQDKRKK | MLALKDPVHT | VSLQQFIYEK | LKAQQEILGE | QGFQSLMETV |
| 970 | |||||
| DTEIVTQLQE | FLQGF |