Q02932

PR
Gene name
KAP120 (YPL125W)
Protein name
Importin beta-like protein KAP120
Names
Karyopherin-120
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YPL125W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-58 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q02932

Entry ID Method Resolution Chain Position Source
6FVB X-ray 330 A A 2-1032 PDB
AF-Q02932-F1 Predicted AlphaFoldDB

12 variants for Q02932

Variant ID(s) Position Change Description Diseaes Association Provenance
s16-313412 9 N>S No SGRP
s16-313493 36 R>K No SGRP
s16-313831 149 V>I No SGRP
s16-314082 232 D>E No SGRP
s16-314212 276 K>Q No SGRP
s16-315003 539 F>L No SGRP
s16-315355 657 G>R No SGRP
s16-315511 709 D>N No SGRP
s16-315712 776 V>L No SGRP
s16-316016 877 S>C No SGRP
s16-316047 887 I>M No SGRP
s16-316204 940 R>G No SGRP

No associated diseases with Q02932

3 regional properties for Q02932

Type Name Position InterPro Accession
repeat Pentapeptide repeat 501 - 566 IPR001646
conserved_site Sugar transporter, conserved site 250 - 275 IPR005829
domain Major facilitator superfamily domain 154 - 722 IPR020846

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
nuclear import signal receptor activity Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein.
nuclear localization sequence binding Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.
small GTPase binding Binding to a small monomeric GTPase.

1 GO annotations of biological process

Name Definition
protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UI26 IPO11 Importin-11 Homo sapiens (Human) PR
Q8K2V6 Ipo11 Importin-11 Mus musculus (Mouse) PR
10 20 30 40 50 60
MASSLNELNL VQVLEQASNP QHIRSDVQKL AEQQLRQWET QAGFHYLLQS IYLNLSNSLQ
70 80 90 100 110 120
IRWLAVIQFK NGVDKYWRST RINAIPKDEK ASIRGRLFEM IDEQNNQLCI QNAQASARIA
130 140 150 160 170 180
RLDFPVEWPT LFEDLENLLN DEIIRKDSVK IYNILMHINQ IVKVLGTARI GRCRPAMQSK
190 200 210 220 230 240
VPLILPLIVR IYLQSFEEWT TSSNLNYEDL SSLQVSYLAL KVLRRIICEG YDRPQTDQSV
250 260 270 280 290 300
CDFIKLSVSH FEMLISNHEN FKKFDIYEKF IKCLGKLYFN LVTGSPANFI LLPCSTQILI
310 320 330 340 350 360
TYTRLIFDKA PKVYRENSDV TGDFWEQTAI RGLLILKRVI NFIHKKGAIT LKARSDKLTI
370 380 390 400 410 420
DASINKINTE FLNENLITRL VDTLMEWYLR LRPTELENWF MDPEEWINEQ MATSYEYQIR
430 440 450 460 470 480
PCAENVFQDL MNTFSELLVP YLLKKIENDA SKLSNSLDDF LRKDAIYASF QLSASAVSEM
490 500 510 520 530 540
VDFDRLLIQV FLPEATNTNI SGDELRIIRR RVALIINEWS TVKCSEESKS LCYKLFTNFL
550 560 570 580 590 600
TDEDDKVVLL TTVQTVRTMV DDWNFNKDTF QPFLTENVHL LLRKILPSVS LTETRLYVLN
610 620 630 640 650 660
TLSDIIIQTK PLISRDLLVE ILQIIPNLWE IATNNASEAI LANALLRLLR NLVSSLGSQS
670 680 690 700 710 720
HLTWDIAIPV VALACDPSSM QYQLLSEDGY ELWGMLLQNF SSHDQEFDDK FVELVPFLKY
730 740 750 760 770 780
GIETHTEILP TLLEIIKSYA LILNPVDFFS NNTFQDIFKQ MSKYLLKLRE DSFQLVLEIW
790 800 810 820 830 840
EILILSNESD YENLLLQKFY ETGVLSALFD AIFLEEAPSS YLCSQIIQII ARISYVNPDA
850 860 870 880 890 900
LMTFLATYHD NLPTSNENAR MPESIRKIVS KDQTYDSVVN KLLTGWIVCF RDIFDPKFKK
910 920 930 940 950 960
VHILGISSLL RTGLVPILTE FSSIASLWIE MLEEINETNR GDCEKYHLND IVTEQSIAFH
970 980 990 1000 1010 1020
PLTAEQLRYH QLCKNNDPVH NISLKDFISQ SMEYLESHLG VERYQEFLKT INPSLLENLQ
1030
MFLSIQPQEA RP