Q7TMY7
Gene name |
Ipo8 |
Protein name |
Importin-8 |
Names |
Imp8, Ran-binding protein 8, RanBP8 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:320727 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q7TMY7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7TMY7-F1 | Predicted | AlphaFoldDB |
43 variants for Q7TMY7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388834690 | 74 | P>S | No | EVA | |
| rs3388875198 | 96 | I>F | No | EVA | |
| rs3388875220 | 124 | P>H | No | EVA | |
| rs3388871898 | 146 | W>* | No | EVA | |
| rs3388871972 | 160 | Y>* | No | EVA | |
| rs3388846920 | 224 | Q>L | No | EVA | |
| rs3388864416 | 239 | R>W | No | EVA | |
| rs3388869543 | 255 | E>V | No | EVA | |
| rs3388872478 | 256 | L>V | No | EVA | |
| rs3388847001 | 257 | V>M | No | EVA | |
| rs3388834710 | 259 | W>R | No | EVA | |
| rs3388873316 | 314 | Q>* | No | EVA | |
| rs3397556299 | 324 | Q>E | No | EVA | |
| rs3397632833 | 328 | N>* | No | EVA | |
| rs3388872034 | 331 | N>Y | No | EVA | |
| rs3388871961 | 354 | V>M | No | EVA | |
| rs3388852192 | 355 | I>V | No | EVA | |
| rs3388860628 | 359 | M>K | No | EVA | |
| rs3388834712 | 393 | A>E | No | EVA | |
| rs3397556348 | 467 | M>L | No | EVA | |
| rs3388865360 | 475 | A>V | No | EVA | |
| rs3388869170 | 557 | D>V | No | EVA | |
| rs3388873344 | 559 | V>I | No | EVA | |
| rs3388873386 | 560 | T>S | No | EVA | |
| rs3388875173 | 571 | S>R | No | EVA | |
| rs3388860615 | 622 | V>M | No | EVA | |
| rs3388852172 | 672 | W>* | No | EVA | |
| rs3388869373 | 673 | Q>E | No | EVA | |
| rs3388872020 | 674 | L>V | No | EVA | |
| rs3388860560 | 704 | D>Y | No | EVA | |
| rs3396788516 | 730 | A>T | No | EVA | |
| rs3388875828 | 771 | R>G | No | EVA | |
| rs3388867250 | 784 | Q>L | No | EVA | |
| rs3388869207 | 790 | L>F | No | EVA | |
| rs3397556353 | 790 | L>H | No | EVA | |
| rs3388872531 | 796 | L>Q | No | EVA | |
| rs3397631668 | 899 | E>V | No | EVA | |
| rs3388867236 | 903 | S>G | No | EVA | |
| rs3388869224 | 937 | E>D | No | EVA | |
| rs3388872504 | 945 | S>N | No | EVA | |
| rs3388869401 | 980 | A>T | No | EVA | |
| rs3397621318 | 991 | Q>* | No | EVA | |
| rs3388867254 | 991 | Q>R | No | EVA |
No associated diseases with Q7TMY7
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATPase-coupled transmembrane transporter activity | Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. |
| small GTPase binding | Binding to a small monomeric GTPase. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein import into nucleus | The directed movement of a protein from the cytoplasm to the nucleus. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDLNRIIQAL | KGTIDPKLRI | AAETELNQSY | KIINFAPSLL | RIIVSDHVEF | PVRQAAAIYL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KNMVTQYWPD | REPPPGEVIF | PFNIHENDRQ | QIRDNIVEGI | IRSPDLVRVQ | LTMCLRVIIR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HDFPGHWPAV | VDKIDYYLQS | PNSGSWLGSL | LCLYQLVKTY | EYKKAEEREP | LLAAMQIFLP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RIQQQILQLL | PDASHYSVLL | QKQILKIFYA | LVQYALPLQL | VNHQTMTTWM | EIFRTIIDRT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VPPETLQIDE | DDRPELVWWK | CKKWALHIVA | RLFERYGSPG | NVTKEYFEFS | EFFLKTYAVG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IQQVLLKILD | QYRQKEYIAP | RVLQQAFNYL | NQGVVHAVTW | KQMKPHIQNI | SEDVIFSVMC |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YKDEDEELWQ | EDPYEYIRMK | FDIFEDYASP | TTAAQTLLYT | AAKKRKEVLP | KMMAFCYQIL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TDPNFDPRKK | DGALHVIGSL | AEILLKKSLF | KDQIELFLQN | HVFPLLMSNL | GYLRARSCWV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LHAFSSLKFH | NELNLRNAVE | LAKKSLIEDE | EMPVKVEAAL | ALQSLISNQA | QAKEHMKPYV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RFIMQELLHI | VRETENDDVT | NVIQKLICEY | SQDVASIAVD | TTQHLAEIFG | KVLQSDEYEE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IEDKTVMAMG | ILHTIDTILT | VVEDHPEIIQ | QLENICLRII | DLVLQKHVIE | FYEEILSLAY |
| 670 | 680 | 690 | 700 | 710 | 720 |
| NLTCHTISPQ | MWQLLGILYE | VFQQDCFEYF | TDMMPLLHNY | VTVDTNALLS | NPKHLEVLFT |
| 730 | 740 | 750 | 760 | 770 | 780 |
| MCRKVLCGEA | GEDAECYAAK | LLEVIILQCK | GRGIDQCIPL | FIQLVLERLT | RGVKTSELRT |
| 790 | 800 | 810 | 820 | 830 | 840 |
| MCLQVAIAAL | YYSPELLFHT | LEQVQLPHNP | GPVTSQFINQ | WMNDTDYFLG | HHDRKMCIIG |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LSVLLELQNR | PPAVDAVAAQ | ILPSILFLFL | GLKQVCATRQ | TVNRENHSKA | EKVDIEENEE |
| 910 | 920 | 930 | 940 | 950 | 960 |
| ISSEEEEETS | VSAQAMQSQI | GRSEEEDDDD | WDEEVLEETA | LEGFSTPLDL | DNSVDEYQFF |
| 970 | 980 | 990 | 1000 | ||
| TQALLTVQNR | DAAWYQLLVA | PLSEDQKRKL | QEVYTLAEHR | RTLAAGQFHI |