Q8K2D6

PR
Gene name
Dctd
Protein name
Deoxycytidylate deaminase
Names
dCMP deaminase
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:320685
EC number
3.5.4.12: In cyclic amidines
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-43 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8K2D6

Entry ID Method Resolution Chain Position Source
AF-Q8K2D6-F1 Predicted AlphaFoldDB

17 variants for Q8K2D6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388964888 17 E>D No EVA
rs3388983387 27 A>V No EVA
rs3388959452 30 S>G No EVA
rs3388976918 41 I>N No EVA
rs214620179 64 L>Q No EVA
rs3388970569 85 A>V No EVA
rs3388954414 111 N>K No EVA
rs3388935327 137 E>K No EVA
rs3388964929 144 L>M No EVA
rs3388983601 152 F>I No EVA
rs246907828 160 S>N No EVA
rs246907828 160 S>T No EVA
rs3388970609 164 I>F No EVA
rs3388983618 166 F>S No EVA
rs3388935289 173 P>S No EVA
rs215762717 176 K>N No EVA
rs3388935256 178 Q>H No EVA

No associated diseases with Q8K2D6

3 regional properties for Q8K2D6

Type Name Position InterPro Accession
domain Cytidine and deoxycytidylate deaminase domain 14 - 145 IPR002125
binding_site APOBEC/CMP deaminase, zinc-binding 84 - 117 IPR016192
domain Deoxycytidylate deaminase domain 17 - 138 IPR035105

Functions

Description
EC Number 3.5.4.12 In cyclic amidines
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
dCMP deaminase activity Catalysis of the reaction: dCMP + H2O = dUMP + NH3.
identical protein binding Binding to an identical protein or proteins.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
dTMP biosynthetic process The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate).
dUMP biosynthetic process The chemical reactions and pathways resulting in the formation of dUMP, deoxyuridine monophosphate (2'-deoxyuridine 5'-phosphate).

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32321 DCTD Deoxycytidylate deaminase Homo sapiens (Human) PR
Q5M9G0 Dctd Deoxycytidylate deaminase Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MSDISCKKRD DYLEWPEYFM AVAFLSAQRS KDPSSQVGAC IVNTENKIVG IGYNGMPNGC
70 80 90 100 110 120
SDDLLPWRRT AENKLDTKYP YVCHAELNAI MNKNSADVKG CSMYVALFPC NECAKLIIQA
130 140 150 160 170
GIKEVIFMSD KYHDSEETTA ARLLFKLAGV TFRKFTPKYS KIVIDFDSIN SRPSQKPQ