AiPD: Autoinhibited Protein Database

P32321

Gene name	DCTD
Protein name	Deoxycytidylate deaminase
Names	dCMP deaminase
Species	Homo sapiens (Human)
KEGG Pathway	hsa:1635
EC number	3.5.4.12: In cyclic amidines
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-43 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-43 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for P32321

Entry ID	Method	Resolution	Chain	Position	Source
2W4L	X-ray	210 A	A/B/C/D/E/F	5-173	PDB
AF-P32321-F1	Predicted				AlphaFoldDB

172 variants for P32321

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs112988256 CA3149297	3	E>*		No	ClinGen ExAC gnomAD
rs112988256 CA111776717	3	E>K		No	ClinGen ExAC gnomAD
COSM1319359 CA358831788 rs1164402011	5	S>F	Variant assessed as Somatic; 0.0 impact. haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1561350184 CA358831782	6	C>F		No	ClinGen Ensembl
rs1367129393 CA358831762	9	R>Q		No	ClinGen gnomAD
CA3149296 rs746633039	9	R>W		No	ClinGen ExAC TOPMed gnomAD
CA3149293 rs377621038	11	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs757869621 CA111776683	11	D>H		No	ClinGen ExAC gnomAD
rs757869621 CA3149294	11	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA3149292 rs765732784	12	Y>H		No	ClinGen ExAC gnomAD
COSM481089 rs1488036260 CA358831732	14	E>K	kidney Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1430721035 CA358831721	15	W>*		No	ClinGen TOPMed
rs757823170 CA358831717 CA3149291	15	W>C		No	ClinGen ExAC TOPMed gnomAD
CA358831724 rs1268137687	15	W>R		No	ClinGen gnomAD
rs754183953 CA3149290	16	P>A		No	ClinGen ExAC gnomAD
rs1263550784 CA358831712	16	P>L		No	ClinGen TOPMed gnomAD
CA358831707 rs1232492109	17	E>G		No	ClinGen TOPMed gnomAD
CA358831706 rs1232492109	17	E>V		No	ClinGen TOPMed gnomAD
rs764778071 CA111776633	18	Y>D		No	ClinGen TOPMed gnomAD
CA358831692 rs1321877483	19	F>S		No	ClinGen TOPMed
rs764555298 CA3149289	21	A>S		No	ClinGen ExAC gnomAD
rs760975082 CA3149288	22	V>G		No	ClinGen ExAC gnomAD
CA358831672 rs1401403033	22	V>M		No	ClinGen gnomAD
CA3149287 rs775729712	23	A>G		No	ClinGen ExAC gnomAD
CA3149286 rs767645014	24	F>L		No	ClinGen ExAC TOPMed gnomAD
CA358831654 rs1170671935	25	L>S		No	ClinGen TOPMed gnomAD
CA3149284 rs373876391	26	S>P		No	ClinGen ESP ExAC TOPMed
CA358831633 rs774638661	28	Q>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	29	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1271261379 CA358831617	30	S>R		No	ClinGen TOPMed
rs185585697 CA3149255	38	G>D		No	ClinGen 1000Genomes ExAC gnomAD
rs1201804124 CA358831553	38	G>R		No	ClinGen TOPMed gnomAD
rs1201804124 CA358831554	38	G>S		No	ClinGen TOPMed gnomAD
CA111776143 rs778279392	39	A>S		No	ClinGen ExAC TOPMed gnomAD
COSM291546 CA3149253 rs778279392	39	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA358831537 rs200811706	41	I>L		No	ClinGen 1000Genomes ExAC TOPMed
rs200811706 CA3149252	41	I>V		No	ClinGen 1000Genomes ExAC TOPMed
rs202145611 CA3149249	42	V>L		No	ClinGen ESP TOPMed gnomAD
CA3149248 rs202145611	42	V>M		No	ClinGen ESP TOPMed gnomAD
CA3149247 rs570024473	43	N>S		No	ClinGen 1000Genomes ExAC gnomAD
CA3149246 rs755220679	45	E>D		No	ClinGen ExAC gnomAD
rs1490853447 CA358831492	47	K>N		No	ClinGen TOPMed
rs1336468197 CA358831499	47	K>Q		No	ClinGen gnomAD
rs748000886 CA111776097	48	I>T		No	ClinGen Ensembl
rs1374970068 CA358831478	50	G>R		No	ClinGen gnomAD
rs750532987 CA3149242	53	Y>C		No	ClinGen ExAC gnomAD
rs764076068 CA3149241	54	N>D		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	57	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs35932500 CA3149239	58	N>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs771818941 CA3149238	59	G>E		No	ClinGen ExAC gnomAD
rs771818941 CA358831414	59	G>V		No	ClinGen ExAC gnomAD
CA358831410 rs1256303361	60	C>Y		No	ClinGen gnomAD
CA358831403 rs1182328149	61	S>C		No	ClinGen gnomAD
COSM1053587 CA3149236 rs773939009	64	V>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs748828324 CA3149234	66	P>T		No	ClinGen ExAC gnomAD
TCGA novel	67	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1357581290 CA358831353	68	R>K		No	ClinGen gnomAD
rs1382643391 CA358831332	71	A>E		No	ClinGen TOPMed
CA358831311 rs1446155672	74	K>*		No	ClinGen gnomAD
CA3149233 CA3149232 rs770313616	74	K>N		No	ClinGen ExAC TOPMed gnomAD
CA111775990 rs771052913	74	K>T		No	ClinGen Ensembl
rs1356941479 CA358831304	75	L>R		No	ClinGen TOPMed
CA3149231 rs368912929	76	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	76	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3149230 rs368912929	76	D>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA358831283 rs1358687652	79	Y>N		No	ClinGen gnomAD
CA3149227 rs374532338	80	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA3149228 rs751975911	80	P>S		No	ClinGen ExAC TOPMed gnomAD
rs150650253 CA111775933	81	Y>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs150650253	81	Y>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA358831266 rs1215334241	81	Y>F		No	ClinGen gnomAD
rs765269080 CA3149224	82	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1329262382 CA358829816	84	H>R		No	ClinGen TOPMed
rs762837387 CA3149199	85	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA358829756 rs1218325233	89	A>V		No	ClinGen TOPMed
rs1302390223 CA358829752	90	I>V		No	ClinGen TOPMed
CA358829737 rs1468371372	91	M>T		No	ClinGen gnomAD
CA3149195 rs761223056	93	K>*		No	ClinGen ExAC TOPMed gnomAD
rs373155698 CA358829694	94	N>I		No	ClinGen ESP TOPMed gnomAD
CA111758847 rs373155698	94	N>S		No	ClinGen ESP TOPMed gnomAD
CA111758831 rs17849458 COSM1053583	95	S>L	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs965237149 CA111758829	96	T>A		No	ClinGen Ensembl
rs1295071160 CA358829672	96	T>I		No	ClinGen gnomAD
CA358829674 rs1295071160	96	T>S		No	ClinGen gnomAD
rs776168243 CA3149191	97	D>N		No	ClinGen ExAC TOPMed gnomAD
rs776168243 CA3149192	97	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA3149189 rs746261082	98	V>M		No	ClinGen ExAC
rs778939354 CA111758790	100	G>A		No	ClinGen ExAC TOPMed gnomAD
rs778939354 CA3149188	100	G>V		No	ClinGen ExAC TOPMed gnomAD
CA358829626 rs1370033880	101	C>R		No	ClinGen gnomAD
CA3149187 rs757569331	101	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs749358760 CA358829613	102	S>C		No	ClinGen ExAC TOPMed gnomAD
CA3149186 rs749358760	102	S>G		No	ClinGen ExAC TOPMed gnomAD
CA3149185 rs767472686	102	S>M		No	ClinGen ExAC gnomAD
CA358829591 rs1426658528	103	M>I		No	ClinGen gnomAD
CA358829600 rs1171871089 COSM1618646	103	M>L	liver [Cosmic]	No	ClinGen cosmic curated TOPMed
CA358829594 rs1414557564	103	M>T		No	ClinGen gnomAD
CA358829580 rs1435253624	104	Y>C		No	ClinGen TOPMed
CA3149182 rs777881225	105	V>I		No	ClinGen ExAC TOPMed gnomAD
CA358829565 rs1398556445	106	A>T		No	ClinGen TOPMed
rs751459371 CA3149180	107	L>S		No	ClinGen ExAC TOPMed gnomAD
CA3149179 rs780062742	108	F>L		No	ClinGen ExAC TOPMed gnomAD
CA111758708 rs907672867	109	P>R		No	ClinGen TOPMed
rs1250979154 CA358829515	110	C>S		No	ClinGen gnomAD
rs758061563 CA3149177	113	C>R		No	ClinGen ExAC gnomAD
CA358829474 rs764782245	114	A>S		No	ClinGen ExAC TOPMed gnomAD
CA3149175 rs764782245 COSM1053582	114	A>T	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs761605580 CA3149174	115	K>T		No	ClinGen ExAC TOPMed
rs753365252 CA3149173	118	I>V		No	ClinGen ExAC TOPMed gnomAD
CA358829415 rs1370835018	119	Q>H		No	ClinGen gnomAD
CA358829417 rs1191226291	119	Q>R		No	ClinGen TOPMed
rs1478097014 CA358829407	120	A>G		No	ClinGen TOPMed
CA3149172 rs763654823	120	A>P		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	121	G>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760141198 CA3149150	122	I>V		No	ClinGen ExAC gnomAD
rs774550136 CA3149149	124	E>*		No	ClinGen ExAC gnomAD
rs1579655125 CA358828922	124	E>A		No	ClinGen Ensembl
TCGA novel	124	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs771246854 CA3149148	125	V>M		No	ClinGen ExAC gnomAD
CA358828847 rs1398229856	128	M>I		No	ClinGen TOPMed
rs770067384 CA3149144	128	M>T		No	ClinGen ExAC gnomAD
CA3149145 rs773366639	128	M>V		No	ClinGen ExAC gnomAD
CA358828826 rs1484865886	130	D>H		No	ClinGen gnomAD
rs755963936 CA111757451	131	K>N		No	ClinGen TOPMed gnomAD
rs1561314904 CA358828791	131	K>T		No	ClinGen Ensembl
rs373102751 CA3149143	133	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs781379454 CA3149142	134	D>E		No	ClinGen ExAC gnomAD
rs554883051 CA3149141	135	S>N		No	ClinGen 1000Genomes ExAC gnomAD
CA358828664 rs1297073291	137	E>K		No	ClinGen gnomAD
rs1384917728 CA358828649	138	A>T		No	ClinGen gnomAD
CA111757442 rs386683038	140	A>D		No	ClinGen Ensembl
rs1294563556 CA358828614	141	A>T		No	ClinGen gnomAD
rs778735165 CA3149139	141	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA111757438 rs868801856	142	R>S		No	ClinGen gnomAD
CA358828582 rs1478257399	144	L>V		No	ClinGen gnomAD
rs1016915974 CA111757426	147	M>I		No	ClinGen Ensembl
rs749096266 CA3149137	147	M>T		No	ClinGen ExAC gnomAD
rs755893484 CA3149135	149	G>R		No	ClinGen ExAC TOPMed gnomAD
CA358828516 rs1579654180	150	V>G		No	ClinGen Ensembl
CA3149134 rs779256460	150	V>L		No	ClinGen ExAC TOPMed gnomAD
CA3149133 rs779256460	150	V>M		No	ClinGen ExAC TOPMed gnomAD
rs752056632 CA3149131	152	F>V		No	ClinGen ExAC TOPMed gnomAD
rs769584873	153	R>=	Variant assessed as Somatic; 4.729e-05 impact. [NCI-TCGA]	No	NCI-TCGA
CA3149129 rs763298312 COSM1249837	153	R>Q	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs766885547 CA3149130	153	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1415277775 CA358828401	155	F>L		No	ClinGen TOPMed
CA3149095 rs747908932	156	I>L		No	ClinGen ExAC gnomAD
TCGA novel	156	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780075881 CA3149094	157	P>L		No	ClinGen ExAC TOPMed gnomAD
CA358828386 rs780075881	157	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs1012408280 CA111755498	157	P>S		No	ClinGen TOPMed
CA111755493 rs1000881314	160	S>G		No	ClinGen gnomAD
rs746506003 CA3149092	160	S>N		No	ClinGen ExAC gnomAD
CA111755489 rs902533637	163	V>F		No	ClinGen TOPMed
rs750878147 CA3149089	164	I>L		No	ClinGen ExAC gnomAD
CA3149090 rs750878147	164	I>V		No	ClinGen ExAC gnomAD
rs1042355240 CA111755470	165	D>N		No	ClinGen TOPMed
rs746121899 CA3149088	166	F>C		No	ClinGen ExAC TOPMed gnomAD
rs757571244 CA3149087	168	S>P		No	ClinGen ExAC gnomAD
CA358828310 rs1484370761	169	I>V		No	ClinGen TOPMed gnomAD
rs1241495288 CA358828295	171	S>G		No	ClinGen gnomAD
rs1262322145 CA358828293	171	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs757710383 CA3149085	173	P>L		No	ClinGen ExAC TOPMed gnomAD
rs757710383 CA358828277	173	P>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	173	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752795686 CA3149082	175	Q>*		No	ClinGen ExAC gnomAD
CA111755429 rs867054774	176	K>N		No	ClinGen gnomAD
rs1314932361 CA358828257	176	K>R		No	ClinGen gnomAD
CA358828252 rs1374913127	177	L>F		No	ClinGen gnomAD
rs143183155 CA3149081	178	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	178	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA111755428 rs754244710	179	Q>R		No	ClinGen Ensembl

No associated diseases with P32321

3 regional properties for P32321

Type	Name	Position	InterPro Accession
domain	Cytidine and deoxycytidylate deaminase domain	14 - 145	IPR002125
binding_site	APOBEC/CMP deaminase, zinc-binding	84 - 117	IPR016192
domain	Deoxycytidylate deaminase domain	17 - 138	IPR035105

Functions

		Description
EC Number	3.5.4.12	In cyclic amidines
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name	Definition
dCMP deaminase activity	Catalysis of the reaction: dCMP + H2O = dUMP + NH3.
identical protein binding	Binding to an identical protein or proteins.
zinc ion binding	Binding to a zinc ion (Zn).

3 GO annotations of biological process

Name	Definition
dTMP biosynthetic process	The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate).
dUMP biosynthetic process	The chemical reactions and pathways resulting in the formation of dUMP, deoxyuridine monophosphate (2'-deoxyuridine 5'-phosphate).
pyrimidine nucleotide metabolic process	The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8K2D6	Dctd	Deoxycytidylate deaminase	Mus musculus (Mouse)	PR
Q5M9G0	Dctd	Deoxycytidylate deaminase	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MSEVSCKKRD	DYLEWPEYFM	AVAFLSAQRS	KDPNSQVGAC	IVNSENKIVG	IGYNGMPNGC
70	80	90	100	110	120
SDDVLPWRRT	AENKLDTKYP	YVCHAELNAI	MNKNSTDVKG	CSMYVALFPC	NECAKLIIQA
130	140	150	160	170
GIKEVIFMSD	KYHDSDEATA	ARLLFNMAGV	TFRKFIPKCS	KIVIDFDSIN	SRPSQKLQ