Q5M9G0

PR
Gene name
Dctd
Protein name
Deoxycytidylate deaminase
Names
dCMP deaminase
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:290741
EC number
3.5.4.12: In cyclic amidines
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-43 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5M9G0

Entry ID Method Resolution Chain Position Source
AF-Q5M9G0-F1 Predicted AlphaFoldDB

No variants for Q5M9G0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5M9G0

No associated diseases with Q5M9G0

3 regional properties for Q5M9G0

Type Name Position InterPro Accession
domain Cytidine and deoxycytidylate deaminase domain 14 - 145 IPR002125
binding_site APOBEC/CMP deaminase, zinc-binding 84 - 117 IPR016192
domain Deoxycytidylate deaminase domain 17 - 138 IPR035105

Functions

Description
EC Number 3.5.4.12 In cyclic amidines
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
dCMP deaminase activity Catalysis of the reaction: dCMP + H2O = dUMP + NH3.
identical protein binding Binding to an identical protein or proteins.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
dTMP biosynthetic process The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate).
dUMP biosynthetic process The chemical reactions and pathways resulting in the formation of dUMP, deoxyuridine monophosphate (2'-deoxyuridine 5'-phosphate).

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32321 DCTD Deoxycytidylate deaminase Homo sapiens (Human) PR
Q8K2D6 Dctd Deoxycytidylate deaminase Mus musculus (Mouse) PR
10 20 30 40 50 60
MSDISCKKRD DYLEWPEYFM AVAFLSAQRS KDPSSQVGAC IVNTENKIVG IGYNGMPNGC
70 80 90 100 110 120
SDDLLPWRRT AENKLDTKYP YVCHAELNAI MNKNSADVKG CSMYVALFPC NECAKLIIQA
130 140 150 160 170
GIKEVIFMSD KYHDSEETTA ARLLFKLAGV TFRKFTPKYS KIVIDFDSIN SRPSQKPQ