Q8K1B8
SS
Gene name |
Fermt3 (Kind3, Urp2) |
Protein name |
Fermitin family homolog 3 |
Names |
Kindlin-3 , Unc-112-related protein 2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
mmu:108101 |
EC number |
|
Protein Class |
|
Descriptions
Importin-α is a nuclear import receptor that facilitates the transport of proteins with nuclear localization sequences (NLSs) into the nucleus. It is autoinhibited by its N-terminal region, which occupies the NLS-binding site, preventing unnecessary binding and import activity. Importin-α is autoinhibited in the absence of importin-β and the binding of importin-β alleviates this autoinhibition, which displaces the autoinhibitory sequence.
Autoinhibitory domains (AIDs)
Target domain |
567-665 (F3 subdomain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q8K1B8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5L81 | X-ray | 223 A | A/B | 344-478 | PDB |
| AF-Q8K1B8-F1 | Predicted | AlphaFoldDB |
27 variants for Q8K1B8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389522097 | 45 | V>A | No | EVA | |
| rs3389522438 | 77 | H>L | No | EVA | |
| rs3389534494 | 93 | F>L | No | EVA | |
| rs36766675 | 108 | R>C | No | EVA | |
| rs3389470452 | 122 | Q>K | No | EVA | |
| rs3389524133 | 182 | P>S | No | EVA | |
| rs3389524084 | 189 | A>P | No | EVA | |
| rs3409106305 | 199 | S>C | No | EVA | |
| rs3389517327 | 199 | S>N | No | EVA | |
| rs3389515792 | 207 | P>S | No | EVA | |
| rs3389470413 | 290 | E>K | No | EVA | |
| rs3389479315 | 297 | L>R | No | EVA | |
| rs3389522457 | 302 | N>S | No | EVA | |
| rs3389470485 | 314 | A>D | No | EVA | |
| rs3389522122 | 318 | L>P | No | EVA | |
| rs3389522481 | 347 | T>I | No | EVA | |
| rs30715023 | 347 | T>S | No | EVA | |
| rs217069448 | 353 | K>R | No | EVA | |
| rs3389489826 | 381 | L>P | No | EVA | |
| rs3389538002 | 384 | Y>H | No | EVA | |
| rs3389522132 | 392 | G>R | No | EVA | |
| rs3389470406 | 401 | K>T | No | EVA | |
| rs3389488040 | 423 | P>S | No | EVA | |
| rs3389534532 | 447 | A>V | No | EVA | |
| rs252331448 | 495 | P>S | No | EVA | |
| rs3389515839 | 504 | L>P | No | EVA | |
| rs3389527892 | 550 | D>N | No | EVA |
No associated diseases with Q8K1B8
9 regional properties for Q8K1B8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Armadillo | 92 - 175 | IPR000225-1 |
| repeat | Armadillo | 176 - 218 | IPR000225-2 |
| repeat | Armadillo | 220 - 259 | IPR000225-3 |
| repeat | Armadillo | 261 - 301 | IPR000225-4 |
| repeat | Armadillo | 303 - 344 | IPR000225-5 |
| repeat | Armadillo | 346 - 386 | IPR000225-6 |
| repeat | Armadillo | 389 - 429 | IPR000225-7 |
| domain | Importin-alpha, importin-beta-binding domain | 1 - 70 | IPR002652 |
| repeat | Atypical Arm repeat | 451 - 500 | IPR032413 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell projection | A prolongation or process extending from a cell, e.g. a flagellum or axon. |
| cell-substrate junction | A cell junction that forms a connection between a cell and the extracellular matrix. |
| podosome | An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| integrin binding | Binding to an integrin. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cell-matrix adhesion | The binding of a cell to the extracellular matrix via adhesion molecules. |
| integrin activation | The aggregation, arrangement and bonding together of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, that lead to the increased affinity of the integrin for its extracellular ligands. |
| integrin-mediated signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| leukocyte cell-cell adhesion | The attachment of a leukocyte to another cell via adhesion molecules. |
| platelet aggregation | The adhesion of one platelet to one or more other platelets via adhesion molecules. |
| positive regulation of cell migration | Any process that activates or increases the frequency, rate or extent of cell migration. |
| regulation of cell-cell adhesion mediated by integrin | Any process that modulates the frequency, rate, or extent of cell-cell adhesion mediated by integrin. |
| substrate adhesion-dependent cell spreading | The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q32LP0 | FERMT3 | Fermitin family homolog 3 | Bos taurus (Bovine) | SS |
| Q9VZI3 | Fit1 | Unc-112-related protein | Drosophila melanogaster (Fruit fly) | SS |
| Q96AC1 | FERMT2 | Fermitin family homolog 2 | Homo sapiens (Human) | SS |
| Q9BQL6 | FERMT1 | Fermitin family homolog 1 | Homo sapiens (Human) | SS |
| Q86UX7 | FERMT3 | Fermitin family homolog 3 | Homo sapiens (Human) | EV |
| Q9Y4G6 | TLN2 | Talin-2 | Homo sapiens (Human) | SS |
| Q9Y490 | TLN1 | Talin-1 | Homo sapiens (Human) | EV |
| P59113 | Fermt1 | Fermitin family homolog 1 | Mus musculus (Mouse) | SS |
| Q8CIB5 | Fermt2 | Fermitin family homolog 2 | Mus musculus (Mouse) | SS |
| P26039 | Tln1 | Talin-1 | Mus musculus (Mouse) | EV |
| Q18685 | unc-112 | Protein unc-112 | Caenorhabditis elegans | SS |
| F1Q8X5 | fermt2 | Fermitin family homolog 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKGGETMSVR | RSGYKAVVDG | VGGRRRREDD | MVEIRKAKRE | ESLLKKRREA | LPHSPSADSL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DQKLISCIWS | DERDLLIEAT | TQIRTLLCGE | MFNVRVEEVI | QAGLVPRFVE | FLTWDDSPQL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QFEAAWALTN | IASGTSENTE | VVIDHGAVAI | LVRLLNSPYD | VVREQVVWAL | GNISGDSPRC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RDIVLGHAAL | PSLLLQLNHG | AKLSMLVNAA | WTLSNLCRGK | PQPPFDQVSA | ALPALAQLIR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LDDKELLAYT | CWALVYLSDG | SNEKIQAVIE | ANVCARLIGL | SIHRSPSVIT | PALRTIGNIV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TGNDSQTQHI | IDLQALPCLV | NLLRGSYNKT | IRKEACWTVS | NITAGCQSQI | QAVFDADICP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ALVNLLQNSE | GDVKKEAAWA | ICNAIAGGSY | KQIMFLVKQE | CIKPLCDLLT | CSDTQLVMVC |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LEALKKILKV | GEVFSSRHAE | GIYQCPQTNV | NPHAQLIEEA | EGLEKIEGLQ | SHENNDIYET |
| 490 | 500 | 510 | 520 | ||
| AVKILETYWM | EEEEEEDQEQ | QDMIYFPVDN | FANMPTSSGT | LSEMHCGP |