Q18685
SS
Gene name |
unc-112 (C47E8.7) |
Protein name |
Protein unc-112 |
Names |
Mitogen-inducible mig-2 protein-like , Uncoordinated protein 112 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_C47E8.7 |
EC number |
|
Protein Class |
|
Descriptions
Kindlin-3 is a member of the kindlin family of focal adhesion proteins which bind to integrin beta-chain cytoplasmic domains to regulate integrin function. kindlin-3 is maintained in a homotrimer state, which is different from the monomer that binds integrin β cytoplasmic tails. The trimer formation of kindlin-3 results in an autoinhibited state, as the integrin-binding pocket is blocked by the pleckstrin homology (PH) domain of another protomer. Mutations disrupting the trimer interface (Q471A, A475F, S478A) lead to increased integrin-mediated cell adhesion and spreading, indicating relief from autoinhibition. This autoinhibition regulates kindlin-3’s role in integrin activation and signaling, with implications for diseases like leukocyte adhesion deficiency (LAD) III and cancer.
Autoinhibitory domains (AIDs)
Target domain |
625-720 (F3 subdomain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
0 structures for Q18685
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| No available structures | |||||
No variants for Q18685
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q18685 | |||||
No associated diseases with Q18685
6 regional properties for Q18685
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Pleckstrin homology domain | 402 - 509 | IPR001849 |
| conserved_site | FERM conserved site | 288 - 319 | IPR019747 |
| domain | FERM central domain | 319 - 614 | IPR019748 |
| domain | Band 4.1 domain | 90 - 614 | IPR019749 |
| domain | Kindlin/fermitin, PH domain | 403 - 528 | IPR037837 |
| domain | Kindlin-2, N-terminal | 12 - 94 | IPR040790 |
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell-substrate junction | A cell junction that forms a connection between a cell and the extracellular matrix. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| M band | The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| striated muscle dense body | A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| cell adhesion molecule binding | Binding to a cell adhesion molecule. |
| integrin binding | Binding to an integrin. |
| protein self-association | Binding to a domain within the same polypeptide. |
| protein-macromolecule adaptor activity | The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| cell-matrix adhesion | The binding of a cell to the extracellular matrix via adhesion molecules. |
| establishment of protein localization to organelle | The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. |
| integrin-mediated signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| locomotion | Self-propelled movement of a cell or organism from one location to another. |
| mitochondrion organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. |
| muscle cell cellular homeostasis | The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state. |
| muscle organ development | The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work. |
| positive regulation of locomotion | Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. |
| positive regulation of myosin II filament organization | Any process that activates or increases the frequency, rate or extent of myosin II filament organization. |
| positive regulation of sarcomere organization | Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. |
| regulation of engulfment of apoptotic cell | Any process that modulates the frequency, rate or extent of engulfment of apoptotic cell. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q32LP0 | FERMT3 | Fermitin family homolog 3 | Bos taurus (Bovine) | SS |
| Q9VZI3 | Fit1 | Unc-112-related protein | Drosophila melanogaster (Fruit fly) | SS |
| Q86UX7 | FERMT3 | Fermitin family homolog 3 | Homo sapiens (Human) | EV |
| Q9BQL6 | FERMT1 | Fermitin family homolog 1 | Homo sapiens (Human) | SS |
| Q96AC1 | FERMT2 | Fermitin family homolog 2 | Homo sapiens (Human) | SS |
| Q9Y4G6 | TLN2 | Talin-2 | Homo sapiens (Human) | SS |
| Q9Y490 | TLN1 | Talin-1 | Homo sapiens (Human) | EV |
| P59113 | Fermt1 | Fermitin family homolog 1 | Mus musculus (Mouse) | SS |
| Q8CIB5 | Fermt2 | Fermitin family homolog 2 | Mus musculus (Mouse) | SS |
| Q8K1B8 | Fermt3 | Fermitin family homolog 3 | Mus musculus (Mouse) | SS |
| P26039 | Tln1 | Talin-1 | Mus musculus (Mouse) | EV |
| F1Q8X5 | fermt2 | Fermitin family homolog 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAHLVEGTSI | IDGKWQLPIL | VTDLNIQRSI | SVLGNLNVGG | LMLELVSECD | VERDWSDHAL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WWPEKRRWLQ | HTRSTLDQNG | ITAETQLEFT | PMHKEARIQL | PDMQMIDARV | DFSVNSFKAT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KKLCRDLGIR | YSEELSLKRY | IPPEDLRRGT | SDADNMNGPL | SMRPGEESVG | PMTLRKAAPI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FASQSNLDMR | RRGQSPALSQ | SGHIFNAHEM | GTLPRHGTLP | RGVSPSPGAY | NDTMRRTPIM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PSISFSEGLE | NEQFDDALIH | SPRLAPSRDT | PVFRPQNYVE | KAAINRGWLD | SSRSLMEQGI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FEGDIILLRF | KFMNFFDLNP | KYDPVRINQL | YEQAKWSILL | DEFDHTEEEA | TLFAALQLQA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TLQRDSPEPE | ENNKDDVDIL | LDELEQNLDA | AALNRRSDLT | QVPELADYLK | YMKPKKLAAF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KGFKRAFFSF | RDLYLSYHQS | SSDVNSAPLG | HFSLKGCEVS | QDVSVGQQKY | HIKLLLPTAE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GMIDFILKCD | SEHQYARWMA | ACRLASRGKS | MADSSYQQEV | ESIKNLLKMQ | SGNGNENGNS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NTASRKAAAV | KLPNDFNVDE | YISSKYVRRA | RSKQQIQQRV | SDAHGNVRQL | TATEAKLQYI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RAWQALPEHG | IHYFIVRFRN | ARKAELVAVA | VNRLAKLNMD | NGESLKTWRF | ANMKKWHVNW |
| 670 | 680 | 690 | 700 | 710 | |
| EIRHLKIQFE | DEDIEFKPLS | ADCKVVHEFI | GGYIFLSMRS | KEHSQNLDEE | LFHKLTGGWA |