Q32LP0
SS
Gene name |
FERMT3 (KIND3, URP2) |
Protein name |
Fermitin family homolog 3 |
Names |
Kindlin-3 , Unc-112-related protein 2 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:525159 |
EC number |
|
Protein Class |
|
Descriptions
Kindlin-3 is a member of the kindlin family of focal adhesion proteins which bind to integrin beta-chain cytoplasmic domains to regulate integrin function. kindlin-3 is maintained in a homotrimer state, which is different from the monomer that binds integrin β cytoplasmic tails. The trimer formation of kindlin-3 results in an autoinhibited state, as the integrin-binding pocket is blocked by the pleckstrin homology (PH) domain of another protomer. Mutations disrupting the trimer interface (Q471A, A475F, S478A) lead to increased integrin-mediated cell adhesion and spreading, indicating relief from autoinhibition. This autoinhibition regulates kindlin-3’s role in integrin activation and signaling, with implications for diseases like leukocyte adhesion deficiency (LAD) III and cancer.
Autoinhibitory domains (AIDs)
Target domain |
567-665 (F3 subdomain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q32LP0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q32LP0-F1 | Predicted | AlphaFoldDB |
324 variants for Q32LP0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs471866087 | 2 | A>V | No | EVA | |
| rs463939563 | 4 | M>R | No | EVA | |
| rs463939563 | 4 | M>T | No | EVA | |
| rs482257465 | 6 | T>A | No | EVA | |
| rs442849172 | 7 | A>D | No | EVA | |
| rs442849172 | 7 | A>G | No | EVA | |
| rs461374551 | 10 | D>E | No | EVA | |
| rs479977254 | 11 | Y>N | No | EVA | |
| rs446615184 | 11 | Y>S | No | EVA | |
| rs477237135 | 12 | I>F | No | EVA | |
| rs469329058 | 13 | D>A | No | EVA | |
| rs469329058 | 13 | D>G | No | EVA | |
| rs450814751 | 13 | D>Y | No | EVA | |
| rs435969488 | 14 | S>L | No | EVA | |
| rs454528081 | 15 | S>A | No | EVA | |
| rs454528081 | 15 | S>P | No | EVA | |
| rs433662950 | 16 | W>L | No | EVA | |
| rs466597783 | 16 | W>R | No | EVA | |
| rs471806236 | 17 | E>D | No | EVA | |
| rs452132095 | 17 | E>G | No | EVA | |
| rs438990908 | 18 | L>R | No | EVA | |
| rs476166867 | 19 | R>G | No | EVA | |
| rs442769240 | 19 | R>Q | No | EVA | |
| rs461357337 | 20 | V>E | No | EVA | |
| rs461357337 | 20 | V>G | No | EVA | |
| rs440523164 | 21 | F>I | No | EVA | |
| rs440523164 | 21 | F>V | No | EVA | |
| rs459083094 | 22 | I>L | No | EVA | |
| rs450753377 | 22 | I>M | No | EVA | |
| rs477175606 | 22 | I>R | No | EVA | |
| rs462789430 | 23 | G>R | No | EVA | |
| rs447939409 | 24 | E>D | No | EVA | |
| rs481383447 | 24 | E>G | No | EVA | |
| rs481383447 | 24 | E>V | No | EVA | |
| rs433599581 | 25 | E>D | No | EVA | |
| rs466575650 | 25 | E>G | No | EVA | |
| rs445684505 | 26 | D>A | No | EVA | |
| rs464126555 | 26 | D>E | No | EVA | |
| rs432518913 | 27 | P>R | No | EVA | |
| rs476062663 | 28 | E>G | No | EVA | |
| rs457561777 | 28 | E>K | No | EVA | |
| rs436700605 | 29 | A>S | No | EVA | |
| rs440460153 | 31 | S>* | No | EVA | |
| rs473389042 | 31 | S>A | No | EVA | |
| rs440460153 | 31 | S>L | No | EVA | |
| rs471103902 | 32 | L>F | No | EVA | |
| rs471103902 | 32 | L>I | No | EVA | |
| rs444216873 | 32 | L>P | No | EVA | |
| rs481316995 | 33 | T>N | No | EVA | |
| rs462753821 | 33 | T>P | No | EVA | |
| rs462753821 | 33 | T>S | No | EVA | |
| rs448366917 | 35 | R>S | No | EVA | |
| rs478396748 | 36 | V>A | No | EVA | |
| rs445623077 | 37 | T>P | No | EVA | |
| rs437662477 | 39 | E>G | No | EVA | |
| rs450956358 | 40 | S>A | No | EVA | |
| rs450956358 | 40 | S>T | No | EVA | |
| rs469590762 | 41 | H>P | No | EVA | |
| rs436624401 | 41 | H>Q | No | EVA | |
| rs469590762 | 41 | H>R | No | EVA | |
| rs473724381 | 44 | G>W | No | EVA | |
| rs433927954 | 45 | V>L | No | EVA | |
| rs452548218 | 48 | K>Q | No | EVA | |
| rs471037685 | 50 | V>G | No | EVA | |
| rs463060292 | 53 | I>S | No | EVA | |
| rs479309868 | 58 | D>V | No | EVA | |
| rs446370426 | 59 | W>C | No | EVA | |
| rs464521680 | 60 | S>* | No | EVA | |
| rs450085723 | 61 | D>A | No | EVA | |
| rs450085723 | 61 | D>V | No | EVA | |
| rs453779723 | 64 | I>L | No | EVA | |
| rs472261198 | 65 | W>C | No | EVA | |
| rs433070426 | 66 | W>G | No | EVA | |
| rs433070426 | 66 | W>R | No | EVA | |
| rs451631865 | 67 | E>A | No | EVA | |
| rs476184935 | 68 | Q>H | No | EVA | |
| rs443250353 | 70 | R>G | No | EVA | |
| rs461805537 | 71 | Q>R | No | EVA | |
| rs442195656 | 72 | W>C | No | EVA | |
| rs473916470 | 72 | W>G | No | EVA | |
| rs460752253 | 74 | L>R | No | EVA | |
| rs479304639 | 76 | T>A | No | EVA | |
| rs479304639 | 76 | T>P | No | EVA | |
| rs446283259 | 77 | H>P | No | EVA | |
| rs458483297 | 77 | H>Q | No | EVA | |
| rs483056829 | 78 | W>G | No | EVA | |
| rs483056829 | 78 | W>R | No | EVA | |
| rs450013297 | 79 | T>P | No | EVA | |
| rs480528850 | 80 | L>R | No | EVA | |
| rs465799953 | 81 | D>E | No | EVA | |
| rs447739672 | 81 | D>N | No | EVA | |
| rs470114336 | 83 | Y>* | No | EVA | |
| rs451486740 | 83 | Y>C | No | EVA | |
| rs451486740 | 83 | Y>F | No | EVA | |
| rs433000320 | 83 | Y>N | No | EVA | |
| rs451486740 | 83 | Y>S | No | EVA | |
| rs455331574 | 85 | I>T | No | EVA | |
| rs436751273 | 85 | I>V | No | EVA | |
| rs473853150 | 86 | L>R | No | EVA | |
| rs472759445 | 87 | A>G | No | EVA | |
| rs453052489 | 87 | A>P | No | EVA | |
| rs483316591 | 88 | D>A | No | EVA | |
| rs458345925 | 88 | D>H | No | EVA | |
| rs443543781 | 89 | A>P | No | EVA | |
| rs447678260 | 91 | L>R | No | EVA | |
| rs480471545 | 91 | L>V | No | EVA | |
| rs478023427 | 92 | F>Y | No | EVA | |
| rs445049932 | 93 | F>C | No | EVA | |
| rs470023351 | 94 | G>R | No | EVA | |
| rs455669000 | 95 | P>A | No | EVA | |
| rs467345169 | 96 | Q>R | No | EVA | |
| rs434401012 | 97 | H>N | No | EVA | |
| rs452990574 | 97 | H>P | No | EVA | |
| rs471526181 | 97 | H>Q | No | EVA | |
| rs451887525 | 99 | P>H | No | EVA | |
| rs443896899 | 100 | V>G | No | EVA | |
| rs462313843 | 101 | I>T | No | EVA | |
| rs480408178 | 102 | L>P | No | EVA | |
| rs441186384 | 104 | L>P | No | EVA | |
| rs459762732 | 106 | N>T | No | EVA | |
| rs478354826 | 107 | R>G | No | EVA | |
| rs444953923 | 109 | A>G | No | EVA | |
| rs482043630 | 110 | L>P | No | EVA | |
| rs449186052 | 111 | R>L | No | EVA | |
| rs434337466 | 112 | L>H | No | EVA | |
| rs467684275 | 112 | L>V | No | EVA | |
| rs446434693 | 114 | A>P | No | EVA | |
| rs464981990 | 116 | F>L | No | EVA | |
| rs432045326 | 117 | S>P | No | EVA | |
| rs457021396 | 118 | Q>P | No | EVA | |
| rs476819340 | 120 | L>P | No | EVA | |
| rs455843656 | 121 | F>L | No | EVA | |
| rs437395078 | 121 | F>L | No | EVA | |
| rs441121393 | 122 | Q>H | No | EVA | |
| rs474333305 | 122 | Q>P | No | EVA | |
| rs459757912 | 123 | A>G | No | EVA | |
| rs471813469 | 124 | M>K | No | EVA | |
| rs438885797 | 125 | V>M | No | EVA | |
| rs463851504 | 132 | S>G | No | EVA | |
| rs453551070 | 176 | A>G | No | EVA | |
| rs465644228 | 177 | S>* | No | EVA | |
| rs432309890 | 178 | F>C | No | EVA | |
| rs442938493 | 181 | M>I | No | EVA | |
| rs475836967 | 181 | M>L | No | EVA | |
| rs455054571 | 184 | H>L | No | EVA | |
| rs455054571 | 184 | H>P | No | EVA | |
| rs473176722 | 185 | F>S | No | EVA | |
| rs440211272 | 186 | S>P | No | EVA | |
| rs458823954 | 189 | A>P | No | EVA | |
| rs476560157 | 189 | A>V | No | EVA | |
| rs477352852 | 193 | A>P | No | EVA | |
| rs443977054 | 195 | Y>S | No | EVA | |
| rs462374937 | 212 | R>L | No | EVA | |
| rs876488326 | 218 | S>P | No | EVA | |
| rs133866516 | 223 | T>P | No | EVA | |
| rs448072627 | 225 | L>R | No | EVA | |
| rs136662179 | 229 | W>G | No | EVA | |
| rs460089188 | 230 | L>P | No | EVA | |
| rs472275624 | 231 | D>E | No | EVA | |
| rs439260932 | 233 | S>* | No | EVA | |
| rs457874432 | 235 | C>G | No | EVA | |
| rs477618617 | 238 | Q>L | No | EVA | |
| rs477618617 | 238 | Q>P | No | EVA | |
| rs451141541 | 245 | D>G | No | EVA | |
| rs463206138 | 246 | T>P | No | EVA | |
| rs481729171 | 250 | R>S | No | EVA | |
| rs448844391 | 254 | Y>H | No | EVA | |
| rs466927362 | 257 | F>C | No | EVA | |
| rs433999060 | 258 | D>A | No | EVA | |
| rs446084180 | 259 | L>M | No | EVA | |
| rs464682744 | 260 | D>H | No | EVA | |
| rs437707866 | 260 | D>V | No | EVA | |
| rs456184712 | 262 | K>Q | No | EVA | |
| rs435135129 | 277 | W>G | No | EVA | |
| rs453676330 | 278 | D>A | No | EVA | |
| rs472221269 | 282 | E>G | No | EVA | |
| rs439302664 | 287 | T>P | No | EVA | |
| rs471155415 | 290 | E>* | No | EVA | |
| rs444668632 | 290 | E>A | No | EVA | |
| rs444668632 | 290 | E>G | No | EVA | |
| rs463166924 | 291 | M>K | No | EVA | |
| rs475351873 | 292 | M>I | No | EVA | |
| rs442333916 | 293 | V>G | No | EVA | |
| rs460554111 | 295 | A>S | No | EVA | |
| rs478844027 | 295 | A>V | No | EVA | |
| rs482575017 | 296 | A>G | No | EVA | |
| rs458099466 | 296 | A>P | No | EVA | |
| rs468385231 | 298 | Q>R | No | EVA | |
| rs460840436 | 299 | Y>S | No | EVA | |
| rs472373327 | 300 | H>Y | No | EVA | |
| rs439563694 | 303 | K>* | No | EVA | |
| rs458034441 | 305 | S>P | No | EVA | |
| rs482914384 | 310 | V>L | No | EVA | |
| rs381858901 | 316 | T>I | No | EVA | |
| rs450148825 | 328 | S>T | No | EVA | |
| rs461933719 | 331 | E>G | No | EVA | |
| rs480507410 | 332 | V>A | No | EVA | |
| rs466087615 | 337 | S>* | No | EVA | |
| rs447511379 | 337 | S>A | No | EVA | |
| rs447511379 | 337 | S>P | No | EVA | |
| rs432698900 | 338 | A>S | No | EVA | |
| rs469816474 | 343 | L>P | No | EVA | |
| rs469816474 | 343 | L>R | No | EVA | |
| rs445205365 | 346 | L>R | No | EVA | |
| rs469756907 | 351 | E>A | No | EVA | |
| rs481911207 | 351 | E>D | No | EVA | |
| rs467619562 | 409 | V>A | No | EVA | |
| rs482573938 | 414 | Q>E | No | EVA | |
| rs463980474 | 416 | F>V | No | EVA | |
| rs439025135 | 424 | S>A | No | EVA | |
| rs478396143 | 425 | P>H | No | EVA | |
| rs458667858 | 426 | E>D | No | EVA | |
| rs440151115 | 427 | G>C | No | EVA | |
| rs454528770 | 428 | M>I | No | EVA | |
| rs473065020 | 428 | M>L | No | EVA | |
| rs479518237 | 445 | M>I | No | EVA | |
| rs460995826 | 454 | G>D | No | EVA | |
| rs442455860 | 456 | T>N | No | EVA | |
| rs475385278 | 459 | D>A | No | EVA | |
| rs457269042 | 460 | S>R | No | EVA | |
| rs438676500 | 469 | I>N | No | EVA | |
| rs471482066 | 470 | L>V | No | EVA | |
| rs434506031 | 471 | A>G | No | EVA | |
| rs474145003 | 475 | L>P | No | EVA | |
| rs455750298 | 476 | Q>H | No | EVA | |
| rs437213728 | 481 | G>V | No | EVA | |
| rs445202971 | 484 | G>C | No | EVA | |
| rs466429000 | 485 | S>A | No | EVA | |
| rs447928252 | 485 | S>C | No | EVA | |
| rs466429000 | 485 | S>P | No | EVA | |
| rs466429000 | 485 | S>T | No | EVA | |
| rs448868008 | 486 | G>A | No | EVA | |
| rs461078409 | 486 | G>R | No | EVA | |
| rs463338377 | 487 | N>D | No | EVA | |
| rs463338377 | 487 | N>H | No | EVA | |
| rs471517209 | 487 | N>K | No | EVA | |
| rs438311326 | 487 | N>S | No | EVA | |
| rs438311326 | 487 | N>T | No | EVA | |
| rs459473010 | 488 | H>N | No | EVA | |
| rs441013260 | 488 | H>P | No | EVA | |
| rs473984076 | 488 | H>Q | No | EVA | |
| rs437305948 | 490 | Q>H | No | EVA | |
| rs455851114 | 490 | Q>P | No | EVA | |
| rs455851114 | 490 | Q>R | No | EVA | |
| rs476698339 | 491 | G>R | No | EVA | |
| rs466516682 | 493 | D>A | No | EVA | |
| rs447964917 | 493 | D>E | No | EVA | |
| rs466516682 | 493 | D>G | No | EVA | |
| rs433147124 | 493 | D>H | No | EVA | |
| rs468766443 | 494 | A>G | No | EVA | |
| rs435813245 | 494 | A>P | No | EVA | |
| rs450234915 | 495 | S>P | No | EVA | |
| rs481977258 | 496 | A>P | No | EVA | |
| rs444838289 | 497 | E>A | No | EVA | |
| rs444838289 | 497 | E>G | No | EVA | |
| rs463424581 | 497 | E>Q | No | EVA | |
| rs459509750 | 499 | L>P | No | EVA | |
| rs474099740 | 500 | N>H | No | EVA | |
| rs443377000 | 500 | N>K | No | EVA | |
| rs461924039 | 500 | N>S | No | EVA | |
| rs461924039 | 500 | N>T | No | EVA | |
| rs451821096 | 501 | P>R | No | EVA | |
| rs476776311 | 501 | P>S | No | EVA | |
| rs472571837 | 502 | Y>H | No | EVA | |
| rs472571837 | 502 | Y>N | No | EVA | |
| rs454091148 | 502 | Y>S | No | EVA | |
| rs456686238 | 506 | A>G | No | EVA | |
| rs438177010 | 509 | F>C | No | EVA | |
| rs438177010 | 509 | F>Y | No | EVA | |
| rs469910976 | 510 | Q>E | No | EVA | |
| rs444874755 | 512 | K>Q | No | EVA | |
| rs477640035 | 516 | K>R | No | EVA | |
| rs455008651 | 519 | T>P | No | EVA | |
| rs435298229 | 526 | H>P | No | EVA | |
| rs474663850 | 527 | Q>* | No | EVA | |
| rs456121194 | 529 | V>L | No | EVA | |
| rs445939764 | 537 | A>G | No | EVA | |
| rs464504640 | 537 | A>T | No | EVA | |
| rs433794919 | 542 | I>V | No | EVA | |
| rs448156613 | 545 | W>C | No | EVA | |
| rs466803837 | 545 | W>R | No | EVA | |
| rs481565511 | 547 | S>P | No | EVA | |
| rs463005098 | 548 | L>P | No | EVA | |
| rs477188780 | 553 | I>S | No | EVA | |
| rs459120542 | 557 | V>G | No | EVA | |
| rs440682029 | 559 | R>G | No | EVA | |
| rs476656156 | 576 | L>Q | No | EVA | |
| rs439624657 | 579 | I>S | No | EVA | |
| rs472922955 | 581 | L>F | No | EVA | |
| rs435816040 | 586 | V>G | No | EVA | |
| rs436859007 | 593 | S>R | No | EVA | |
| rs456543537 | 593 | S>T | No | EVA | |
| rs469666277 | 595 | M>I | No | EVA | |
| rs444838344 | 596 | R>G | No | EVA | |
| rs444838344 | 596 | R>S | No | EVA | |
| rs466051350 | 598 | W>G | No | EVA | |
| rs447564592 | 600 | V>F | No | EVA | |
| rs447564592 | 600 | V>I | No | EVA | |
| rs480546524 | 603 | D>A | No | EVA | |
| rs449863487 | 606 | Q>P | No | EVA | |
| rs482796260 | 607 | V>E | No | EVA | |
| rs446175159 | 608 | A>P | No | EVA | |
| rs479120921 | 608 | A>V | No | EVA | |
| rs460555863 | 616 | N>T | No | EVA | |
| rs441951794 | 617 | V>A | No | EVA | |
| rs444626570 | 633 | I>M | No | EVA | |
| rs470991636 | 635 | G>V | No | EVA | |
| rs439290722 | 641 | T>S | No | EVA | |
| rs453731993 | 648 | E>G | No | EVA | |
| rs435178187 | 649 | E>G | No | EVA | |
| rs468502386 | 650 | L>P | No | EVA | |
| rs456415884 | 651 | D>E | No | EVA | |
| rs437865556 | 652 | E>G | No | EVA | |
| rs464377675 | 653 | D>A | No | EVA | |
| rs464377675 | 653 | D>V | No | EVA | |
| rs445744001 | 657 | Q>K | No | EVA | |
| rs479163696 | 657 | Q>R | No | EVA | |
| rs467019306 | 658 | L>R | No | EVA | |
| rs448516097 | 659 | T>P | No | EVA | |
| rs463118761 | 662 | H>N | No | EVA | |
| rs444714373 | 662 | H>P | No | EVA | |
| rs477462543 | 662 | H>Q | No | EVA | |
| rs458992120 | 663 | E>G | No | EVA | |
| rs440584860 | 666 | F>G | No | EVA |
No associated diseases with Q32LP0
5 regional properties for Q32LP0
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell projection | A prolongation or process extending from a cell, e.g. a flagellum or axon. |
| cell-substrate junction | A cell junction that forms a connection between a cell and the extracellular matrix. |
| podosome | An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| integrin binding | Binding to an integrin. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cell-matrix adhesion | The binding of a cell to the extracellular matrix via adhesion molecules. |
| integrin activation | The aggregation, arrangement and bonding together of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, that lead to the increased affinity of the integrin for its extracellular ligands. |
| integrin-mediated signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| leukocyte cell-cell adhesion | The attachment of a leukocyte to another cell via adhesion molecules. |
| platelet aggregation | The adhesion of one platelet to one or more other platelets via adhesion molecules. |
| positive regulation of cell migration | Any process that activates or increases the frequency, rate or extent of cell migration. |
| regulation of cell-cell adhesion mediated by integrin | Any process that modulates the frequency, rate, or extent of cell-cell adhesion mediated by integrin. |
| substrate adhesion-dependent cell spreading | The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9VZI3 | Fit1 | Unc-112-related protein | Drosophila melanogaster (Fruit fly) | SS |
| Q96AC1 | FERMT2 | Fermitin family homolog 2 | Homo sapiens (Human) | SS |
| Q9BQL6 | FERMT1 | Fermitin family homolog 1 | Homo sapiens (Human) | SS |
| Q86UX7 | FERMT3 | Fermitin family homolog 3 | Homo sapiens (Human) | EV |
| Q9Y4G6 | TLN2 | Talin-2 | Homo sapiens (Human) | SS |
| Q9Y490 | TLN1 | Talin-1 | Homo sapiens (Human) | EV |
| P59113 | Fermt1 | Fermitin family homolog 1 | Mus musculus (Mouse) | SS |
| Q8CIB5 | Fermt2 | Fermitin family homolog 2 | Mus musculus (Mouse) | SS |
| Q8K1B8 | Fermt3 | Fermitin family homolog 3 | Mus musculus (Mouse) | SS |
| P26039 | Tln1 | Talin-1 | Mus musculus (Mouse) | EV |
| Q18685 | unc-112 | Protein unc-112 | Caenorhabditis elegans | SS |
| F1Q8X5 | fermt2 | Fermitin family homolog 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGMKTATGD | YIDSSWELRV | FIGEEDPEAE | SLTLRVTGES | HIGGVLLKIV | EEIKRKQDWS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DHAIWWEQKR | QWLLQTHWTL | DKYGILADAR | LFFGPQHRPV | ILRLPNRRAL | RLRASFSQPL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FQAMVAICRL | LSIRHPEEMS | LLRAPEKEKK | KKKEKEPEEE | VYDLTKVVLV | GGVAPASFRG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MPAHFSDSAQ | TEACYHMLSR | PQPPPDPLLL | QRLPRPSSLL | DKTQLHSRWL | DSSRCLMQQG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IKAGDTLWLR | FKYYSFFDLD | PKTDPVRLTQ | LYEQARWDLL | LEEIDCTEEE | MMVFAALQYH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| INKLSQSGEV | DEPAGTDSGL | DDLDLALSNL | EVKLEGSAPT | DMLDSLTTIP | ELKDHLRIFR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PRKLTLKGYR | QHWVVFKETT | LSYYKSQDEA | PGEPIQQLNL | KGCEVVPDVN | VSGQKFCIKL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LVPSPEGMSE | IYLRCQDEQQ | YARWMAGCRL | ASKGRTMADS | SYSSEVQAIL | AFLSLQRTGG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GGGGSGNHPQ | GPDASAEGLN | PYGLVAPRFQ | RKFKAKQLTP | RILEAHQNVA | QLSLSEAQLR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FIQAWQSLPD | FGISYVVVRF | KGSRKDEILG | IANNRLIRID | LSVGDVVKTW | RFSNMRQWNV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NWDIRQVAIE | FDEHINVAFS | CVSASCRIVH | EYIGGYIFLS | TRERARGEEL | DEDLFLQLTG |
| GHEAF |