Q8JIY8

PR
Gene name
nifk (mki67ip, mki67ipl)
Protein name
MKI67 FHA domain-interacting nucleolar phosphoprotein
Names
Nucleolar phosphoprotein NOPP34-like protein
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:317644
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-67 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8JIY8

Entry ID Method Resolution Chain Position Source
AF-Q8JIY8-F1 Predicted AlphaFoldDB

No variants for Q8JIY8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8JIY8

No associated diseases with Q8JIY8

2 regional properties for Q8JIY8

Type Name Position InterPro Accession
domain RNA recognition motif domain 45 - 123 IPR000504
domain MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding 204 - 240 IPR021043

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

1 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.

1 GO annotations of biological process

Name Definition
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3SZM1 NIFK MKI67 FHA domain-interacting nucleolar phosphoprotein Bos taurus (Bovine) PR
Q9BYG3 NIFK MKI67 FHA domain-interacting nucleolar phosphoprotein Homo sapiens (Human) PR
10 20 30 40 50 60
MTEGKSSDKP AKRLLALNPK EDAEFQKKVQ QVKKRPQTGQ TLSPGVLYVG HLPRGLFEPQ
70 80 90 100 110 120
LKSYFEQFGK VLRLRVSRSK KTGGSKGYGF VEFECDEVAK IVAETMNNYL MGERIIKCHV
130 140 150 160 170 180
IPPEKVHEKL FVGSIAGFKK PKYPAVTRYN KTHTEDDVKK VGTKLLSKES KLRKRLAAKG
190 200 210 220 230 240
IDYDFPGFAA QIPAKKAPSE ANVSVCSEDV TPVCTPSLLE RRKSLRVEDD DVDDEIVIKV
250 260
KPLPENSDDV EESEEESAEE DEGEEEEAA