AiPD: Autoinhibited Protein Database

Gene name	NIFK (MKI67IP)
Protein name	MKI67 FHA domain-interacting nucleolar phosphoprotein
Names	Nucleolar protein interacting with the FHA domain of pKI-67
Species	Bos taurus (Bovine)
KEGG Pathway	bta:509598
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-66 (Predicted disordered autoinhibitory region) PR

1-66 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q3SZM1-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs135748641	4	F>V	No	EVA
rs437553829	7	P>S	No	EVA
rs799807718	21	K>R	No	EVA
rs481482940	22	F>S	No	EVA
rs459882200	24	K>M	No	EVA
rs447937249	32	R>P	No	EVA
rs478989026	77	S>C	No	EVA
rs475265633	97	D>H	No	EVA
rs441644313	125	K>M	No	EVA
rs474647799	127	H>P	No	EVA
rs436317289	134	W>*	No	EVA
rs456020605	136	M>I	No	EVA
rs440725581	152	N>D	No	EVA
rs467694673	181	I>V	No	EVA
rs464468193	196	E>K	No	EVA
rs445940873	197	E>D	No	EVA
rs482008681	199	A>D	No	EVA
rs482008681	199	A>G	No	EVA
rs448165683	211	Q>R	No	EVA
rs720336028	220	A>T	No	EVA
rs714005232	231	V>M	No	EVA
rs459838315	235	G>V	No	EVA
rs470987988	239	V>F	No	EVA
rs452552082	245	L>F	No	EVA
rs437063132	246	E>K	No	EVA
rs476516146	251	E>Q	No	EVA
rs454679996	253	A>P	No	EVA
rs454679996	253	A>S	No	EVA
rs436164767	255	M>K	No	EVA
rs465956931	259	D>H	No	EVA
rs447312303	260	K>E	No	EVA
rs464930166	260	K>N	No	EVA
rs432084074	260	K>R	No	EVA
rs449600605	261	D>H	No	EVA
rs482277530	261	D>V	No	EVA
rs481651206	267	K>N	No	EVA
rs448738416	267	K>R	No	EVA
rs459925569	272	G>C	No	EVA
rs441271781	275	E>*	No	EVA
rs477571730	275	E>G	No	EVA
rs458892815	277	T>R	No	EVA
rs443651881	280	T>S	No	EVA
rs476652153	282	S>A	No	EVA
rs463898554	290	R>*	No	EVA
rs472399053	297	Q>R	No	EVA

Type	Name	Position	InterPro Accession
domain	WWE domain	22 - 106	IPR004170
domain	Poly(ADP-ribose) polymerase, catalytic domain	123 - 338	IPR012317

		Description
EC Number
Subcellular Localization	Nucleus, nucleolus Chromosome	Localizes to mitotic chromosomes in conjunction with MKI67
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
condensed nuclear chromosome	A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

Name	Definition
RNA binding	Binding to an RNA molecule or a portion thereof.

Name	Definition
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9BYG3	NIFK	MKI67 FHA domain-interacting nucleolar phosphoprotein	Homo sapiens (Human)	PR
Q8JIY8	nifk	MKI67 FHA domain-interacting nucleolar phosphoprotein	Danio rerio (Zebrafish) (Brachydanio rerio)	PR