Q8IH00
Gene name |
Mat89Ba |
Protein name |
Nucleolar protein 6 |
Names |
Maternal transcript 89Ba |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG12785 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8IH00
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8IH00-F1 | Predicted | AlphaFoldDB |
No variants for Q8IH00
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8IH00 | |||||
No associated diseases with Q8IH00
6 regional properties for Q8IH00
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Nrap protein domain 1 | 177 - 319 | IPR035082 |
| domain | Nrap protein, domain 2 | 323 - 461 | IPR035367 |
| domain | Nrap protein, domain 3 | 466 - 628 | IPR035368 |
| domain | Nrap protein, domain 4 | 657 - 842 | IPR035369 |
| domain | Nrap protein, domain 5 | 844 - 1002 | IPR035370 |
| domain | Nrap protein, domain 6 | 1007 - 1130 | IPR035371 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| condensed nuclear chromosome | A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome. |
| CURI complex | A protein complex that is involved in the transcription of ribosomal genes. In Saccharomyces this complex consists of Ckb2p, Utp22p, Rrp7p and Ifh1p. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| small-subunit processome | A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
| UTP-C complex | A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Rrp7p, Utp22p, Ckb1p, Cka1p, Ckb2p and Cka2p. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA binding | Binding to an RNA molecule or a portion thereof. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| rRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
| tRNA export from nucleus | The directed movement of tRNA from the nucleus to the cytoplasm. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P53254 | UTP22 | U3 small nucleolar RNA-associated protein 22 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9H6R4 | NOL6 | Nucleolar protein 6 | Homo sapiens (Human) | PR |
| Q5M7P5 | nol6 | Nucleolar protein 6 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRFVQGNIMP | GKLVGSPKGA | ARTGTQAIAH | AGDHSDLDEP | KPKIAKSDPP | STAIPKKNNF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KQREGTKNVK | PPTLEEMKEL | RDTQNLFHSN | LFKLQVKEML | EELQLKQKYT | DFIENWLESF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TAFTRQLKDG | LMERTHLEVP | MKLSEKPTGF | VFSKPTREPY | LIGAAATGTL | LGPKIVVDVA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LEMPKESLHK | EDYLNLRYDQ | KRALYLTYVT | ERMMESPDYA | EDQFNFNYYA | NNPLKPVLEL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IPVTKQVNKH | LQVRLFITAP | LSSFKPGRFV | PWNNNIRPSF | YGDEWDEKDP | LPSTQHYNAN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VLFDLTLSEN | QAQLDKAFKS | RRNFQDGLLL | LKVWLRQRQL | DIGYSGFGAH | ILAAFIVYLN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TQRILHQSSS | SYQVARTVWN | QLANTDWTKG | ISLSVAPIQT | EELNKFAEHY | DVCFIDFTGQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HNLCANIPLY | LYQRVREEAK | LAVELLNDMK | LNSFPLIFMQ | KCPLYSRVDN | ILKISNYSCI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NQMLTLHSHP | RIKYDFANYG | YPQLLHLLTE | LLKKGLAERV | HSILPLETAT | AAWPVEKKAP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VIGKYIQLGL | ILQPEHAYQV | LNKGPAANDD | HEGAEEFRRF | WGEKSNLRRF | QDGSITEAVV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| WGTAQDSPAK | KRLIVRQIVL | HLLEHHLQLD | SKEVQYIGGE | LDQVYQLSPW | FKVNKLKTKL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| PLGQDTDAEA | LSPHVIRCYD | ELARQLHGLN | DLPLEIVSIS | GVSPIFRYCE | PQPVLPQALL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VENRILASSI | QRVVIQLGQS | GKWPTELGAL | RALKTAFLIE | IGEKLEAQCR | LHWVMSADGL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LVLKQGYCFL | IELAHNKELA | LLKQEVTERG | ITTYIDNAAS | RSLERQHYIL | PKVSGALHSL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| HQTYSAFGST | VLLAKRWLAT | QLLDDGLWPD | MATELLVAHL | FQQRYAPQSI | AAPQTGFIRF |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LQLLSHSDFN | GELFLLNFNN | SWQEQQIADL | EHNYRSNRQS | YPPLAVATSY | DMQHAGRLWT |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| SDQSPSQRVL | GHVTRLARHA | LEIIETSLMS | KDLRFVRPAQ | LFRASNEGYD | LVIQFKPDLV |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| PNSLSYDLGS | PFVSFSQPNF | SLPRAGSDYI | ARIVGLLRSA | YSDFAAFFYN | PHGGKELGIV |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| WRPPTEFAAK | PFKVTELQAC | SPCGNKKVQV | LKETLLEDFK | LLLKDFYLRI | ATPEELKREQ |
| 1150 | 1160 | 1170 | 1180 | 1190 | |
| REHQKPMRYF | DANKAEEESK | PKPKKHRQRK | GTGKKALPKR | KRLIKSSTLK | VLK |