P53254

PR
Gene name
UTP22 (YGR090W)
Protein name
U3 small nucleolar RNA-associated protein 22
Names
U3 snoRNA-associated protein 22, U three protein 22
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YGR090W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-112 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

25 structures for P53254

Entry ID Method Resolution Chain Position Source
4M5D X-ray 197 A A 1-1237 PDB
5WLC EM 380 A NH 1-1237 PDB
5WYJ EM 870 A CB 1-1237 PDB
5WYK EM 450 A CB 1-1237 PDB
6KE6 EM 340 A RE 1-1237 PDB
6LQP EM 320 A RE 1-1237 PDB
6LQQ EM 410 A RE 1-1237 PDB
6LQR EM 860 A RE 1-1237 PDB
6LQS EM 380 A RE 1-1237 PDB
6LQT EM 490 A RE 1-1237 PDB
6LQU EM 370 A RE 1-1237 PDB
6ZQA EM 440 A UV 1-1237 PDB
6ZQB EM 390 A UV 1-1237 PDB
6ZQC EM 380 A UV 1-1237 PDB
6ZQD EM 380 A UV 1-1237 PDB
6ZQE EM 710 A UV 1-1237 PDB
6ZQF EM 490 A UV 1-1237 PDB
7AJT EM 460 A UV 1-1237 PDB
7AJU EM 380 A UV 1-1237 PDB
7D4I EM 400 A RE 1-1237 PDB
7D5S EM 460 A RE 1-1237 PDB
7D5T EM 600 A RE 1-1237 PDB
7D63 EM 1230 A RE 1-1237 PDB
7SUK EM 399 A NH 97-1237 PDB
AF-P53254-F1 Predicted AlphaFoldDB

19 variants for P53254

Variant ID(s) Position Change Description Diseaes Association Provenance
s07-662570 70 N>S No SGRP
s07-662606 82 A>V No SGRP
s07-662621 87 D>A No SGRP
s07-662800 147 A>T No SGRP
s07-662801 147 A>V No SGRP
s07-662984 208 T>I No SGRP
s07-663074 238 H>R No SGRP
s07-663200 280 L>P No SGRP
s07-663335 325 S>F No SGRP
s07-663707 449 S>C No SGRP
s07-663814 485 Y>H No SGRP
s07-663905 515 I>T No SGRP
s07-664151 597 R>K No SGRP
s07-664704 781 D>E No SGRP
s07-664780 807 L>F No SGRP
s07-664916 852 F>C No SGRP
s07-664999 880 A>T No SGRP
s07-665897 1179 K>R No SGRP
s07-665927 1189 L>P No SGRP

No associated diseases with P53254

6 regional properties for P53254

Type Name Position InterPro Accession
domain Nrap protein domain 1 203 - 355 IPR035082
domain Nrap protein, domain 2 358 - 514 IPR035367
domain Nrap protein, domain 3 521 - 690 IPR035368
domain Nrap protein, domain 4 704 - 904 IPR035369
domain Nrap protein, domain 5 906 - 1091 IPR035370
domain Nrap protein, domain 6 1093 - 1232 IPR035371

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
90S preribosome A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
CURI complex A protein complex that is involved in the transcription of ribosomal genes. In Saccharomyces this complex consists of Ckb2p, Utp22p, Rrp7p and Ifh1p.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
small-subunit processome A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
UTP-C complex A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Rrp7p, Utp22p, Ckb1p, Cka1p, Ckb2p and Cka2p.

1 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.

8 GO annotations of biological process

Name Definition
maturation of SSU-rRNA Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule.
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
nucleolar large rRNA transcription by RNA polymerase I The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template transcribed by RNA polymerase I.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of ribosomal protein gene transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes mediated by RNA polymerase II.
ribosomal small subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
tRNA export from nucleus The directed movement of tRNA from the nucleus to the cytoplasm.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8IH00 Mat89Ba Nucleolar protein 6 Drosophila melanogaster (Fruit fly) PR
Q9H6R4 NOL6 Nucleolar protein 6 Homo sapiens (Human) PR
Q5M7P5 nol6 Nucleolar protein 6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MATSVKRKAS ETSDQNIVKV QKKHSTQDST TDNGSKENDH SSQAINERTV PEQENDESDT
70 80 90 100 110 120
SPESNEVATN TAATRHNGKV TATESYDIHI ARETAELFKS NIFKLQIDEL LEQVKLKQKH
130 140 150 160 170 180
VLKVEKFLHK LYDILQEIPD WEEKSLAEVD SFFKNKIVSV PFVDPKPIPQ NTNYKFNYKK
190 200 210 220 230 240
PDISLIGSFA LKAGIYQPNG SSIDTLLTMP KELFEKKDFL NFRCLHKRSV YLAYLTHHLL
250 260 270 280 290 300
ILLKKDKLDS FLQLEYSYFD NDPLLPILRI SCSKPTGDSL SDYNFYKTRF SINLLIGFPY
310 320 330 340 350 360
KVFEPKKLLP NRNCIRIAQE SKEQSLPATP LYNFSVLSSS THENYLKYLY KTKKQTESFV
370 380 390 400 410 420
EATVLGRLWL QQRGFSSNMS HSGSLGGFGT FEFTILMAAL LNGGGINSNK ILLHGFSSYQ
430 440 450 460 470 480
LFKGVIKYLA TMDLCHDGHL QFHSNPENSS SSPASKYIDE GFQTPTLFDK STKVNILTKM
490 500 510 520 530 540
TVSSYQILKE YAGETLRMLN NVVQDQFSNI FLTNISRFDN LKYDLCYDVQ LPLGKYNNLE
550 560 570 580 590 600
TSLAATFGSM ERVKFITLEN FLAHKITNVA RYALGDRIKY IQIEMVGQKS DFPITKRKVY
610 620 630 640 650 660
SNTGGNHFNF DFVRVKLIVN PSECDKLVTK GPAHSETMST EAAVFKNFWG IKSSLRRFKD
670 680 690 700 710 720
GSITHCCVWS TSSSEPIISS IVNFALQKHV SKKAQISNET IKKFHNFLPL PNLPSSAKTS
730 740 750 760 770 780
VLNLSSFFNL KKSFDDLYKI IFQMKLPLSV KSILPVGSAF RYTSLCQPVP FAYSDPDFFQ
790 800 810 820 830 840
DVILEFETSP KWPDEITSLE KAKTAFLLKI QEELSANSST YRSFFSRDES IPYNLEIVTL
850 860 870 880 890 900
NILTPEGYGF KFRVLTERDE ILYLRAIANA RNELKPELEA TFLKFTAKYL ASVRHTRTLE
910 920 930 940 950 960
NISHSYQFYS PVVRLFKRWL DTHLLLGHIT DELAELIAIK PFVDPAPYFI PGSLENGFLK
970 980 990 1000 1010 1020
VLKFISQWNW KDDPLILDLV KPEDDIRDTF ETSIGAGSEL DSKTMKKLSE RLTLAQYKGI
1030 1040 1050 1060 1070 1080
QMNFTNLRNS DPNGTHLQFF VASKNDPSGI LYSSGIPLPI ATRLTALAKV AVNLLQTHGL
1090 1100 1110 1120 1130 1140
NQQTINLLFT PGLKDYDFVV DLRTPIGLKS SCGILSATEF KNITNDQAPS NFPENLNDLS
1150 1160 1170 1180 1190 1200
EKMDPTYQLV KYLNLKYKNS LILSSRKYIG VNGGEKGDKN VITGLIKPLF KGAHKFRVNL
1210 1220 1230
DCNVKPVDDE NVILNKEAIF HEIAAFGNDM VINFETD