Q5M7P5
Gene name |
nol6 |
Protein name |
Nucleolar protein 6 |
Names |
|
Species |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
KEGG Pathway |
xtr:496825 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5M7P5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5M7P5-F1 | Predicted | AlphaFoldDB |
No variants for Q5M7P5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5M7P5 | |||||
No associated diseases with Q5M7P5
6 regional properties for Q5M7P5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Nrap protein domain 1 | 178 - 316 | IPR035082 |
| domain | Nrap protein, domain 2 | 322 - 460 | IPR035367 |
| domain | Nrap protein, domain 3 | 466 - 625 | IPR035368 |
| domain | Nrap protein, domain 4 | 646 - 843 | IPR035369 |
| domain | Nrap protein, domain 5 | 845 - 1000 | IPR035370 |
| domain | Nrap protein, domain 6 | 1002 - 1136 | IPR035371 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| CURI complex | A protein complex that is involved in the transcription of ribosomal genes. In Saccharomyces this complex consists of Ckb2p, Utp22p, Rrp7p and Ifh1p. |
| small-subunit processome | A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
| UTP-C complex | A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Rrp7p, Utp22p, Ckb1p, Cka1p, Ckb2p and Cka2p. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA binding | Binding to an RNA molecule or a portion thereof. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| rRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
| tRNA export from nucleus | The directed movement of tRNA from the nucleus to the cytoplasm. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P53254 | UTP22 | U3 small nucleolar RNA-associated protein 22 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q8IH00 | Mat89Ba | Nucleolar protein 6 | Drosophila melanogaster (Fruit fly) | PR |
| Q9H6R4 | NOL6 | Nucleolar protein 6 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQKKRNRAGP | PQQEAASDDG | EMSDSSDKME | VAQGKGKSAV | KRAPDADEVL | RPVKLSKSDL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YKPPTNDELN | RLKETEHLFH | TNLLRMQIEE | LLQEVKLKEK | RRKTIDGFLR | EINTLLGTIP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ETPQTDLTDQ | TWLPDSIKVP | ILQVPYQVKG | KFCFLPPSSI | KVVGSYLLGT | CIKPEINVDL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AVTMPQEILQ | AKDNLNQRYS | RKRALYLAHI | ASHLANNELF | SSVKFTYMNS | NHLKPVLLLR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PYGKDEKLVT | VRIHVCPPPG | FFKISRLYPN | KNNVRTAWYT | EQETEGVNEP | PTPHYNNTIL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SDLTLEHHLH | HLSNCASDFP | GMKDAVALLK | VWLHQRQLDK | GYGCFNGFLA | AMLISYLLSK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NKINKVMSGY | QVLRNTLQFL | ATTDLTVNGI | TMATSTDSSL | PSLHDFHEAF | QVVFVDPLGV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VNLCADMTTN | KYHQIQFEAR | ESLKVLDDTS | ADGFHLLLMV | PKPFVRTFDH | VFHLTNVSKL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QGTCKKMKLL | NQLIDQGGDY | LATSLPYVLS | ILSKGLGPRV | ALLSHTLPHR | PEWDIGEEPA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KHRDSSLLSV | GLLLEAELHT | SVLEKGPAAD | SSQALDFRAF | WGEKSELRRF | QDGSICEAVV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| WPGSSLCEKR | KVPELIVKYL | LELHADIPES | CISYTGNVLD | CVLTRGKEAG | TEEEKMVGII |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QSYDDLSRKL | WNLTDLPLTV | TSVQGTHPCL | RYSDVFPPLP | VKPDWSSYQL | LREKKCLVPN |
| 730 | 740 | 750 | 760 | 770 | 780 |
| PEKPCPAYVA | PVKVICHMEG | SGKWPQDKDA | IKRVKAAFQI | RLAELLRAQH | QLLCNPSATH |
| 790 | 800 | 810 | 820 | 830 | 840 |
| TDVYKDGYVF | RVQVAYHREP | QYMKEIVTPE | GMLKYQDTEE | SLQLELETLH | LPSLTSTLHG |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LHQQHPAFGG | TSRMAKRWIH | SQLLGDSFSE | ECVDLLVAHL | FLHPAPYSPP | SSPQVGFLRF |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LHLLATFDWK | NSPLIVNLNG | ELKGPDYTEI | QNDFISARAQ | LPVMFIATPK | DKKDSLWTKT |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| QPTAQILQRL | IVLCLESLRA | LEQQLMDPSG | SQDYKMTFRP | PLDLYDILIR | LNPKQIPRHR |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| EAVDQPAKSF | FRGLLKEGAQ | VKDLMFPVVG | YDPVQCYLQE | LREAYGEFAL | FFHDKHGGDV |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| IGVLWKPSGF | EPQPFKTTNM | TGRVMDGKSA | KPLLVPNVEA | IVEDFEILGE | GLVASVEART |
| ERWSI |