Q8HZR1
Gene name |
PTGS1 (COX1) |
Protein name |
Prostaglandin G/H synthase 1 |
Names |
Cyclooxygenase-1, COX-1, Prostaglandin H2 synthase 1, PGH synthase 1, PGHS-1, PHS 1, Prostaglandin-endoperoxide synthase 1 |
Species |
Canis lupus familiaris (Dog) (Canis familiaris) |
KEGG Pathway |
cfa:403544 |
EC number |
1.14.99.1: Miscellaneous |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8HZR1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8HZR1-F1 | Predicted | AlphaFoldDB |
4 variants for Q8HZR1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs24619391 | 17 | L>M | No | EVA | |
| rs853183608 | 57 | R>H | No | EVA | |
| rs852291113 | 597 | E>Q | No | EVA | |
| rs850883934 | 598 | R>Q | No | EVA |
No associated diseases with Q8HZR1
1 regional properties for Q8HZR1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | EGF-like domain | 35 - 73 | IPR000742 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.14.99.1 | Miscellaneous |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| heme binding | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. |
| metal ion binding | Binding to a metal ion. |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. |
| peroxidase activity | Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O. |
| prostaglandin-endoperoxide synthase activity | Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cyclooxygenase pathway | The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2. |
| inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
| regulation of blood pressure | Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. |
| response to oxidative stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O62664 | PTGS1 | Prostaglandin G/H synthase 1 | Bos taurus (Bovine) | PR |
| P23219 | PTGS1 | Prostaglandin G/H synthase 1 | Homo sapiens (Human) | PR |
| P35354 | PTGS2 | Prostaglandin G/H synthase 2 | Homo sapiens (Human) | PR |
| P22437 | Ptgs1 | Prostaglandin G/H synthase 1 | Mus musculus (Mouse) | PR |
| Q05769 | Ptgs2 | Prostaglandin G/H synthase 2 | Mus musculus (Mouse) | PR |
| Q9C9U3 | DOX2 | Alpha-dioxygenase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSRGSRLHRW | PLLLLLLLLL | PPPPVLPAEA | RTPAPVNPCC | YYPCQHQGIC | VRFGLDRYQC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DCTRTGYSGP | NCTIPELWTW | LRNSLRPSPS | FLHFLLTHGR | WFWEFINATF | IRDMLMRLVL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TARSNLIPSP | PTYNIAHDYI | SWESFSNVSY | YTRVLPSVPQ | DCPTPMGTKG | KKQLPDAQLL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GRRFLLRRKF | IPDPQGTNLM | FAFFAQHFTH | QFFKTSGKMG | PGFTKALGHG | VDLGHIYGDN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LDRQYQLRLF | KDGKLKYQVL | DGEMYPPSVE | EAPVLMHYPR | GILPQSQMAV | GQEVFGLLPG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LMLYATLWLR | EHNRVCDLLK | AEHPTWGDEQ | LFQTARLILI | GETIKIVIEE | YVQQLSGYFL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QLKFDPELLF | SAQFQYRNRI | AMEFNQLYHW | HPLMPDSFWV | GSQEYSYEQF | LFNTSMLTHY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GIEALVDAFS | RQSAGRIGGG | RNIDHHVLHV | AVETIKESRE | LRLQPFNEYR | KRFGMRPYMS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FQELTGEKEM | AAELEELYGD | IDALEFYPGL | LLEKCHPNSI | FGESMIEIGA | PFSLKGLLGN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PICSPEYWKP | STFGGEMGFN | MVKTATLKKL | VCLNTKTCPY | VSFRVPDPHQ | DGGPGVERPS |
| TEL |