AiPD: Autoinhibited Protein Database

P35354

Gene name	PTGS2
Protein name	Prostaglandin G/H synthase 2
Names	Cyclooxygenase-2, COX-2, PHS II, Prostaglandin H2 synthase 2, PGH synthase 2, PGHS-2, Prostaglandin-endoperoxide synthase 2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5743
EC number	1.14.99.1: Miscellaneous
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

113-185 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

113-185 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

8 structures for P35354

Entry ID	Method	Resolution	Chain	Position	Source
5F19	X-ray	204 A	A/B	19-569	PDB
5F1A	X-ray	238 A	A/B	19-570	PDB
5IKQ	X-ray	241 A	A/B	19-569	PDB
5IKR	X-ray	234 A	A/B	19-569	PDB
5IKT	X-ray	245 A	A/B	19-569	PDB
5IKV	X-ray	251 A	A/B	19-569	PDB
5KIR	X-ray	270 A	A/B	19-569	PDB
AF-P35354-F1	Predicted				AlphaFoldDB

347 variants for P35354

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs533479217 CA34082403	3	A>P		No	ClinGen 1000Genomes TOPMed gnomAD
CA344062794 rs533479217	3	A>S		No	ClinGen 1000Genomes TOPMed gnomAD
rs200140544 CA34082402	4	R>G		No	ClinGen Ensembl
rs779244806 CA1299772	5	A>T		No	ClinGen ExAC gnomAD
CA344062780 rs1323381581	5	A>V		No	ClinGen TOPMed gnomAD
TCGA novel	7	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344062743 rs755298351	12	L>V		No	ClinGen ExAC gnomAD
CA34082399 rs200906212	13	A>S		No	ClinGen gnomAD
rs1293553620 CA344062727	15	S>G		No	ClinGen gnomAD
CA1299770 rs199946406	17	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1157576579 CA344062707	18	A>T		No	ClinGen gnomAD
TCGA novel	21	C>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs199737603 CA1299758	23	S>Y		No	ClinGen ExAC TOPMed gnomAD
CA344062636 rs1228524516	26	C>Y		No	ClinGen gnomAD
CA344062613 rs771031623	29	R>L		No	ClinGen ExAC TOPMed gnomAD
rs771031623 CA1299756	29	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA344062605 rs1394592753	31	V>L		No	ClinGen gnomAD
CA34082303 rs201588411	32	C>Y		No	ClinGen Ensembl
rs1571812529 CA344062591	33	M>V		No	ClinGen Ensembl
rs1469636907 CA344062578	34	S>R		No	ClinGen TOPMed gnomAD
rs746777440 CA1299755	34	S>T		No	ClinGen ExAC TOPMed gnomAD
CA344062556 rs1467756337	38	D>H		No	ClinGen gnomAD
CA1299754 rs777767886	40	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs777767886 CA344062538	40	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs945078063 CA34082302	40	Y>H		No	ClinGen Ensembl
CA34082301 rs1039984985	43	D>N		No	ClinGen Ensembl
COSM3376045 rs199661060 COSM3376044 CA34082299	46	R>W	pancreas [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1423245301 CA344062470	50	Y>C		No	ClinGen gnomAD
CA344062430 rs1256555548	55	S>L		No	ClinGen gnomAD
CA344062423 rs373745396	57	P>A		No	ClinGen ESP ExAC gnomAD
CA1299721 rs764607381	57	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA344062408 rs764607381	57	P>Q		No	ClinGen ExAC gnomAD
CA1299750 rs373745396	57	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs373745396 CA1299749	57	P>T		No	ClinGen ESP ExAC gnomAD
COSM1689435 COSM1689434 rs1391277420 CA344062407	58	E>K	skin [Cosmic]	No	ClinGen cosmic curated gnomAD
CA1299720 rs758723919	59	F>L		No	ClinGen ExAC gnomAD
TCGA novel	62	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA34082291 rs189809394	63	I>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs189809394 CA1299719	63	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	64	K>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344062364 rs1159681362	64	K>T		No	ClinGen gnomAD
CA344062317 rs1558251045	71	P>S		No	ClinGen Ensembl
rs764773998 CA1299718	73	T>A		No	ClinGen ExAC gnomAD
CA1299717 rs759289241	74	V>G		No	ClinGen ExAC gnomAD
CA344062295 rs1451690197	75	H>N		No	ClinGen TOPMed gnomAD
rs753282331 CA1299716	75	H>Q		No	ClinGen ExAC gnomAD
rs1195365633 CA344062278	77	I>L		No	ClinGen Ensembl
rs1424440707 CA344062276	77	I>T		No	ClinGen gnomAD
CA1299715 rs765917101	78	L>F		No	ClinGen ExAC gnomAD
rs760272529 CA1299714	79	T>S		No	ClinGen ExAC gnomAD
CA344062249 rs1229416920	81	F>L		No	ClinGen gnomAD
rs866635655 CA34082290	83	G>E		No	ClinGen Ensembl
CA344062239 rs1558250981	83	G>R		No	ClinGen Ensembl
CA344062230 rs1305115452	84	F>S		No	ClinGen TOPMed
CA344062216 rs1331433720	86	N>D		No	ClinGen gnomAD
CA1299713 rs773231889	86	N>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	86	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1299712 rs772180278	87	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1299711 rs199619767	91	I>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1325689156 CA344062181	91	I>T		No	ClinGen gnomAD
rs199619767 CA34082288	91	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1458352165 CA344062174	92	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA1299709 rs201046652	92	P>T		No	ClinGen ExAC TOPMed gnomAD
rs200132172 COSM901217 COSM901218 CA1299708	95	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA1299707 rs145215600	96	N>S		No	ClinGen ESP ExAC gnomAD
TCGA novel	97	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747123567 CA1299705	98	I>V		No	ClinGen ExAC gnomAD
rs1478192334 CA344062127	100	S>G		No	ClinGen gnomAD
CA344062124 rs1378833561	100	S>N		No	ClinGen gnomAD
CA344062077 rs1448517603	105	S>Y		No	ClinGen gnomAD
CA344062074 rs1341821169	106	R>G		No	ClinGen gnomAD
rs1428768336 CA344062053	109	L>M		No	ClinGen gnomAD
TCGA novel	110	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1299678 rs749696563	112	S>G		No	ClinGen ExAC gnomAD
CA344062024 rs1412293053	113	P>T		No	ClinGen gnomAD
CA344062011 rs1451898767	115	T>A		No	ClinGen TOPMed
CA1299677 rs377655174	115	T>I		No	ClinGen ESP ExAC gnomAD
CA344061966 rs1571811749	121	G>D		No	ClinGen Ensembl
rs200314986 CA1299676	122	Y>*		No	ClinGen ExAC gnomAD
rs756733211 CA1299675	124	S>I		No	ClinGen ExAC gnomAD
rs756733211 CA1299673	124	S>N		No	ClinGen ExAC gnomAD
rs202013754 CA1299672	124	S>R		No	ClinGen ExAC gnomAD
rs756733211 CA1299674	124	S>T		No	ClinGen ExAC gnomAD
rs762779324 CA1299670	125	W>L		No	ClinGen ExAC
rs763970406 CA1299671	125	W>R		No	ClinGen ExAC
CA1299668 rs766574554	126	E>G		No	ClinGen ExAC
CA1299669 rs775312199	126	E>K		No	ClinGen ExAC
CA34082218 rs965556832	127	A>G		No	ClinGen Ensembl
TCGA novel	128	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs566984593 CA1299665	133	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA344061861 rs1319817234	137	A>V		No	ClinGen gnomAD
TCGA novel	144	D>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1299662 rs536033236	146	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA344061794 rs1239740288	147	T>I		No	ClinGen TOPMed
rs780636784 CA1299660	148	P>L		No	ClinGen ExAC gnomAD
CA1299646 rs774340680	154	K>E		No	ClinGen ExAC gnomAD
CA344061740 rs1448238237	154	K>R		No	ClinGen TOPMed
rs1308743303 CA344061728	156	Q>K		No	ClinGen gnomAD
CA34082170 rs1057052111	157	L>F		No	ClinGen gnomAD
CA344061719 rs1057052111	157	L>V		No	ClinGen gnomAD
CA1299644 rs749747614	159	D>G		No	ClinGen ExAC gnomAD
CA34082169 rs200842448	160	S>A		No	ClinGen gnomAD
CA344061702 rs200842448	160	S>P		No	ClinGen gnomAD
rs776157771 CA1299643	161	N>S		No	ClinGen ExAC gnomAD
rs770236383 CA344061676	163	I>M		No	ClinGen ExAC gnomAD
rs1455494038 CA344061645	168	L>F		No	ClinGen gnomAD
rs199513587 CA34082168	172	K>E		No	ClinGen gnomAD
CA1299639 rs770539837	172	K>N		No	ClinGen ExAC gnomAD
TCGA novel	173	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1393906666 CA344061611	173	F>S		No	ClinGen gnomAD
rs1247457527 CA344061604	174	I>S		No	ClinGen TOPMed
rs1285554656 CA344061581	177	P>L		No	ClinGen TOPMed
rs1356667566 CA344061578	178	Q>*		No	ClinGen TOPMed
rs535541309 CA34082167	178	Q>R		No	ClinGen TOPMed gnomAD
CA344061527 rs1235898281	185	A>S		No	ClinGen gnomAD
rs201493026 CA34082166	186	F>L		No	ClinGen TOPMed
TCGA novel	186	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	189	Q>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	192	T>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs372267158 CA1299633	200	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs753612005 CA1299632	201	K>M		No	ClinGen ExAC gnomAD
CA344061403 rs1440434396	201	K>N		No	ClinGen TOPMed
CA344061402 rs1291036901	202	R>*		No	ClinGen gnomAD
rs141500962 CA1299631	202	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA34082165 rs919237837	204	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA344061366 rs1358824412	208	N>D		No	ClinGen gnomAD
rs1388462023 CA344061357	209	G>E		No	ClinGen gnomAD
rs751815873 CA344061359 CA1299629	209	G>R		No	ClinGen ExAC gnomAD
rs1477645399 CA344061350	210	L>R		No	ClinGen TOPMed
TCGA novel	216	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA34082088 rs865832855	218	H>Y		No	ClinGen Ensembl
CA344061276 rs1348890069	219	I>M		No	ClinGen gnomAD
rs538414051 CA1299609	219	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs765827639 CA1299607	221	G>S		No	ClinGen ExAC gnomAD
rs558977656 CA1299606	224	L>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1281368683 CA344061230	227	Q>E		No	ClinGen TOPMed
CA344061228 rs1291706641	227	Q>L		No	ClinGen gnomAD
rs761122494 CA1299603	228	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
VAR_016262 COSM424843 CA1299602 rs3218622 COSM424844	228	R>H	breast [Cosmic]	No	ClinGen cosmic curated UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs761122494 COSM1726628 CA1299604 COSM1726629	228	R>S	liver [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
COSM2123329 CA344061205 rs1194680056 COSM2123330	231	R>C	Variant assessed as Somatic; 0.0 impact. pancreas [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs1242261573 CA344061202	231	R>L		No	ClinGen TOPMed
rs868858200 CA34082086	235	D>N		No	ClinGen Ensembl
rs771747733 CA1299601	237	K>R		No	ClinGen ExAC gnomAD
rs747632855 CA1299600	238	M>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	245	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344061088 rs1232662636	245	G>E		No	ClinGen TOPMed gnomAD
CA344061093 rs1291537846	245	G>R		No	ClinGen TOPMed gnomAD
CA344061086 rs1371551676	246	E>Q		No	ClinGen TOPMed gnomAD
rs186230736 CA1299574	247	M>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1299573 rs745639034	248	Y>H		No	ClinGen ExAC gnomAD
CA34082080 rs887880400	250	P>L		No	ClinGen TOPMed
CA344061048 rs1318781700	251	T>I		No	ClinGen TOPMed gnomAD
CA1299571 rs369291855	253	K>R		No	ClinGen ESP ExAC gnomAD
CA344061030 rs1171417967	254	D>V		No	ClinGen TOPMed gnomAD
CA344061021 rs1379502755	255	T>I		No	ClinGen TOPMed
rs1422978070 CA344060968	263	P>S		No	ClinGen gnomAD
CA1299569 rs779300029	264	Q>H		No	ClinGen ExAC gnomAD
rs1274565158 CA344060937	267	E>D		No	ClinGen TOPMed
CA1299566 rs756699181	270	R>P		No	ClinGen ExAC TOPMed gnomAD
CA1299565 rs756699181	270	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs201723686 CA34082077	270	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA34082075 rs914524249	272	A>S		No	ClinGen Ensembl
TCGA novel	275	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767815237 CA1299563	275	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs763851146 CA1299560	285	M>I		No	ClinGen ExAC gnomAD
rs755163066 CA34082073	286	M>T		No	ClinGen Ensembl
rs775124209 CA1299558	290	I>M		No	ClinGen ExAC gnomAD
rs762349072 CA1299559	290	I>V		No	ClinGen ExAC gnomAD
CA1299557 rs769616622	291	W>R		No	ClinGen ExAC gnomAD
CA1299554 rs148160346	293	R>Q		No	ClinGen ESP ExAC gnomAD
COSM901212 COSM901211 rs776721278 CA344060777	293	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA1299552 rs200204426 COSM3803210 COSM3803211	300	D>N	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA1299550 rs749311409	301	V>M		No	ClinGen ExAC gnomAD
CA1299549 rs780245288	305	E>D		No	ClinGen ExAC gnomAD
CA344060686 rs1215146515	306	H>Y		No	ClinGen gnomAD
rs201228846 CA34082072	310	G>D		No	ClinGen TOPMed gnomAD
rs1315583021 CA344060656	310	G>R		No	ClinGen gnomAD
rs1228107146 CA344060583	320	L>V		No	ClinGen TOPMed gnomAD
CA1299546 rs781689400	323	I>L		No	ClinGen ExAC gnomAD
CA344060543 rs1444963388	324	G>A		No	ClinGen gnomAD
TCGA novel	328	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1299525 rs199520386	328	K>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	328	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1462305634 CA344060488	332	E>A		No	ClinGen gnomAD
CA34082040 rs200843740	337	H>R		No	ClinGen Ensembl
CA1299523 rs371762608	341	Y>C		No	ClinGen ESP ExAC gnomAD
CA34082038 rs201764120	342	H>Q		No	ClinGen Ensembl
CA344060405 rs1408773912	344	K>Q		No	ClinGen gnomAD
rs764827141 CA1299522 COSM1601417 COSM1601416	349	P>T	liver [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1156433982 CA344060353	351	L>Q		No	ClinGen TOPMed
rs759085374 CA1299521	355	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1193969719 CA344060322	355	K>N		No	ClinGen gnomAD
rs866862668 COSM3740875 COSM3740876 CA34082036	358	Q>*	liver [Cosmic]	No	ClinGen cosmic curated Ensembl
CA344060293 rs1469641978	359	Y>F		No	ClinGen gnomAD
TCGA novel	360	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200479241 CA34082035	361	N>S		No	ClinGen TOPMed
rs1443094098 CA344060274	362	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	367	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766401496 CA1299519	368	N>S		No	ClinGen ExAC gnomAD
rs1285700548 CA344060220	370	L>V		No	ClinGen gnomAD
rs1389494413 CA344060181	375	P>S		No	ClinGen TOPMed
rs1369349606 CA344060155	379	D>G		No	ClinGen gnomAD
rs767282746 CA1299516	382	Q>H		No	ClinGen ExAC gnomAD
CA344060119 rs1373604934	384	H>L		No	ClinGen gnomAD
CA344060120 rs1373604934	384	H>R		No	ClinGen gnomAD
CA1299513 rs770054837	387	K>E		No	ClinGen ExAC gnomAD
CA344060084 rs776759044	389	N>D		No	ClinGen ExAC TOPMed gnomAD
rs776759044 CA1299511	389	N>H		No	ClinGen ExAC TOPMed gnomAD
CA344060081 rs1412850897	389	N>S		No	ClinGen TOPMed gnomAD
CA34082034 rs201708424	390	Y>H		No	ClinGen 1000Genomes gnomAD
TCGA novel	393	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1299508 rs778162839	393	F>L		No	ClinGen ExAC gnomAD
CA344060046 rs1456144285	394	I>V		No	ClinGen TOPMed gnomAD
TCGA novel	395	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA34082033 rs748500299	399	I>L		No	ClinGen ExAC TOPMed gnomAD
CA34082032 rs367650109	399	I>T		No	ClinGen ESP TOPMed gnomAD
rs748500299 CA1299506	399	I>V		No	ClinGen ExAC TOPMed gnomAD
CA1299504 rs5279 CA344059980	403	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA344059965 rs765917214	406	T>A		No	ClinGen ExAC TOPMed gnomAD
CA1299502 rs765917214	406	T>S		No	ClinGen ExAC TOPMed gnomAD
CA344059961 rs1163455221	407	Q>K		No	ClinGen TOPMed
CA1299501 rs755696929	407	Q>R		No	ClinGen ExAC gnomAD
CA34082031 rs202093833	408	F>L		No	ClinGen gnomAD
rs750338422 CA344059923	412	F>C		No	ClinGen ExAC gnomAD
CA1299500 rs750338422	412	F>S		No	ClinGen ExAC gnomAD
rs1362856586 CA344059925	412	F>V		No	ClinGen gnomAD
rs1413242782 CA344059912	414	R>K		No	ClinGen gnomAD
CA344059895 rs1374896875	416	I>T		No	ClinGen gnomAD
CA1299498 rs761649861	417	A>T		No	ClinGen ExAC gnomAD
CA34082029 rs201373237	417	A>V		No	ClinGen Ensembl
rs1388254963 CA344059885	418	G>D		No	ClinGen gnomAD
rs773830437 CA34081971	420	V>I		No	ClinGen TOPMed gnomAD
rs770221043 CA34081970	421	A>T		No	ClinGen TOPMed
VAR_016263 rs4648279 CA1299480	428	P>A		No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
rs984061797 CA34081969	428	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA1299481 rs4648279	428	P>S		No	ClinGen ExAC TOPMed gnomAD
rs4648279 CA344059814	428	P>T		No	ClinGen ExAC TOPMed gnomAD
rs202020013 CA1299478	429	A>S		No	ClinGen ExAC gnomAD
CA34081968 rs202020013	429	A>T		No	ClinGen ExAC gnomAD
CA1299476 rs754018195	430	V>L		No	ClinGen ExAC TOPMed gnomAD
CA344059796 rs1327334629	431	Q>H		No	ClinGen TOPMed
CA1299474 rs760785915	432	K>E		No	ClinGen ExAC gnomAD
TCGA novel	432	K>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344059787 rs1334024006	433	V>I		No	ClinGen TOPMed gnomAD
CA344059768 rs1306444485	435	Q>H		No	ClinGen gnomAD
rs139215497 CA34081967	436	A>S		No	ClinGen TOPMed gnomAD
rs762156881 CA1299471	438	I>T		No	ClinGen ExAC gnomAD
rs772624685 CA1299472	438	I>V		No	ClinGen ExAC gnomAD
rs749712692 CA1299468	443	Q>H		No	ClinGen ExAC gnomAD
rs769393500 CA1299466	449	F>L		No	ClinGen ExAC gnomAD
rs745382650 CA1299465	454	K>R		No	ClinGen ExAC gnomAD
CA1299464 rs780502264	455	R>C		No	ClinGen ExAC gnomAD
TCGA novel	455	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1274936592 CA344059612	457	M>T		No	ClinGen TOPMed
rs1468314972 CA344059594	460	P>A		No	ClinGen gnomAD
rs1032727927 CA34081963	463	S>P		No	ClinGen Ensembl
CA34081962 rs998560580	466	E>G		No	ClinGen TOPMed gnomAD
CA1299440 rs139787656	471	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA34081889 rs777664238	471	K>N		No	ClinGen ExAC gnomAD
CA1299438 rs758387677	474	S>F		No	ClinGen ExAC gnomAD
CA1299437 rs752484376	475	A>T		No	ClinGen ExAC TOPMed gnomAD
CA1299436 rs141702884	478	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA1299435 rs754811569	479	A>V		No	ClinGen ExAC gnomAD
CA1299433 rs767810225	481	Y>C		No	ClinGen ExAC gnomAD
rs267598241 CA34081888	482	G>S		No	ClinGen Ensembl
rs189679860 CA1299432	483	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1299431 rs751749337	484	I>V		No	ClinGen ExAC gnomAD
CA1299430 rs764695479	487	V>M		No	ClinGen ExAC gnomAD
rs5272 CA34081885 VAR_011980	488	E>G		No	ClinGen UniProt Ensembl dbSNP
CA344059389 rs1210299227	489	L>M		No	ClinGen gnomAD
TCGA novel	491	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1338469357 CA344059338	497	K>E		No	ClinGen gnomAD
COSM1287452 COSM1287451 CA1299428 rs776081537	497	K>N	autonomic_ganglia [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1229095478 CA344059330	498	P>S		No	ClinGen gnomAD
COSM531544 CA34081881 rs200408009 COSM531543	499	R>L	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes NCI-TCGA TOPMed gnomAD
CA34081882 rs200408009	499	R>Q		No	ClinGen 1000Genomes TOPMed gnomAD
COSM901205 CA1299427 rs201405348 COSM901206	499	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1444610498 CA344059317	501	D>H		No	ClinGen gnomAD
rs1376804015 CA344059313	501	D>V		No	ClinGen gnomAD
rs200926368 CA34081879	505	G>S		No	ClinGen Ensembl
CA1299425 rs776118678	506	E>D		No	ClinGen ExAC gnomAD
rs1558246298 CA344059275	507	T>S		No	ClinGen Ensembl
CA1299424 rs770663212	508	M>T		No	ClinGen ExAC gnomAD
rs200030471 CA34081878	510	E>D		No	ClinGen Ensembl
rs5273 CA1299422 VAR_011981	511	V>A		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs5273 CA1299423	511	V>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs771571521 CA1299421	517	L>S		No	ClinGen ExAC gnomAD
CA344059194 rs1333546992	520	L>F		No	ClinGen gnomAD
TCGA novel	522	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1299420 rs748021098	523	N>K		No	ClinGen ExAC gnomAD
CA34081877 rs201342852	524	V>I		No	ClinGen ESP TOPMed gnomAD
CA1299419 rs199820825	525	I>L		No	ClinGen ExAC TOPMed gnomAD
CA344059160 rs199820825	525	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1298886823 CA344059154	526	C>R		No	ClinGen TOPMed
rs1202327911 CA344059140	528	P>A		No	ClinGen gnomAD
CA344059139 rs1202327911	528	P>S		No	ClinGen gnomAD
rs749145998 CA1299417	529	A>T		No	ClinGen ExAC gnomAD
rs201922079 CA1299416	529	A>V		No	ClinGen ExAC gnomAD
rs541453486 CA344059108	532	K>N		No	ClinGen TOPMed
TCGA novel	532	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344059087 rs1332133558	535	T>N		No	ClinGen gnomAD
CA344059053 rs1277787648	540	V>G		No	ClinGen TOPMed
rs751835602 CA1299414	543	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA344059031 rs1356784766	544	I>V		No	ClinGen gnomAD
rs200583134 CA1299412	545	I>T		No	ClinGen ExAC gnomAD
rs895168815 CA34081875	546	N>S		No	ClinGen Ensembl
rs1210271508 CA344059006	547	T>I		No	ClinGen TOPMed
CA344058996 rs1392814387	549	S>L		No	ClinGen gnomAD
TCGA novel	551	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	554	I>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765815931 CA1299410	554	I>M		No	ClinGen ExAC gnomAD
CA1299409 rs759794443	556	N>S		No	ClinGen ExAC gnomAD
CA344058941 rs1188212468	557	N>S		No	ClinGen TOPMed
TCGA novel	558	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1175587406 CA344058922	560	G>R		No	ClinGen gnomAD
CA34081873 rs201730487	561	C>S		No	ClinGen Ensembl
TCGA novel	562	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1299407 rs766007619	563	F>L		No	ClinGen ExAC gnomAD
CA344058886 rs1171962882	565	S>L		No	ClinGen TOPMed
CA34081871 rs201606460	567	S>G		No	ClinGen Ensembl
CA34081870 rs924208743	569	P>A		No	ClinGen TOPMed gnomAD
rs1213910146 CA344058860	569	P>L		No	ClinGen gnomAD
rs924208743 CA344058863	569	P>T		No	ClinGen TOPMed gnomAD
rs772864590 CA1299405	571	P>A		No	ClinGen ExAC gnomAD
CA344058850 rs772864590	571	P>S		No	ClinGen ExAC gnomAD
rs771520748 CA1299404	572	E>D		No	ClinGen ExAC gnomAD
CA344058837 rs1281479804	573	L>F		No	ClinGen TOPMed gnomAD
CA344058829 rs1350517032	574	I>T		No	ClinGen gnomAD
CA344058808 rs1310616336	577	V>A		No	ClinGen TOPMed gnomAD
rs774122358 CA1299402	578	T>I		No	ClinGen ExAC TOPMed gnomAD
rs200492220 CA1299403	578	T>P		No	ClinGen ExAC TOPMed gnomAD
rs933492734 CA34081869	579	I>M		No	ClinGen TOPMed gnomAD
CA344058777 rs1370652272	582	S>I		No	ClinGen TOPMed
CA1299401 rs768699687	585	R>C		No	ClinGen ExAC gnomAD
COSM901197 COSM901198 rs749033694 CA1299400	585	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs749033694 CA344058759	585	R>P		No	ClinGen ExAC TOPMed gnomAD
CA1299398 rs201772944	586	S>Y		No	ClinGen ExAC TOPMed gnomAD
COSM3689211 CA1299396 rs3218625 COSM3689210 VAR_016264	587	G>R	large_intestine [Cosmic]	No	ClinGen cosmic curated UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
rs148865858 CA344058736	589	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA1299392 rs755571974	590	D>G		No	ClinGen ExAC TOPMed gnomAD
CA1299394 COSM3789250 COSM3789251 rs373482960	590	D>N	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs755571974 CA1299393	590	D>V		No	ClinGen ExAC TOPMed gnomAD
rs754301528 CA1299391	591	I>T		No	ClinGen ExAC gnomAD
rs201299558 COSM1222470 COSM1222471 CA34081866	600	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs201299558 CA1299389	600	R>L		No	ClinGen ExAC gnomAD
rs1558245968 CA344058672	600	R>S		No	ClinGen Ensembl

No associated diseases with P35354

5 regional properties for P35354

Type	Name	Position	InterPro Accession
domain	DNA-directed DNA polymerase X	185 - 574	IPR002054
domain	DNA polymerase beta-like, N-terminal domain	188 - 254	IPR010996
binding_site	DNA polymerase family X, binding site	356 - 375	IPR019843
domain	DNA polymerase beta, palm domain	327 - 406	IPR028207
domain	DNA polymerase beta, thumb domain	516 - 574	IPR029398

Functions

		Description
EC Number	1.14.99.1	Miscellaneous
Subcellular Localization	Microsome membrane ; Peripheral membrane protein Endoplasmic reticulum membrane ; Peripheral membrane protein Nucleus inner membrane ; Peripheral membrane protein Nucleus outer membrane ; Peripheral membrane protein	Detected on the lumenal side of the endoplasmic reticulum and nuclear envelope
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

10 GO annotations of cellular component

Name	Definition
caveola	A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum lumen	The volume enclosed by the membranes of the endoplasmic reticulum.
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
neuron projection	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
nuclear inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope.
nuclear outer membrane	The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes.
protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

7 GO annotations of molecular function

Name	Definition
enzyme binding	Binding to an enzyme, a protein with catalytic activity.
heme binding	Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
metal ion binding	Binding to a metal ion.
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor.
peroxidase activity	Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O.
prostaglandin-endoperoxide synthase activity	Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O.
protein homodimerization activity	Binding to an identical protein to form a homodimer.

64 GO annotations of biological process

Name	Definition
aging	A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
angiogenesis	Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
bone mineralization	The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue.
brown fat cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.
cellular response to ATP	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus.
cellular response to fluid shear stress	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface.
cellular response to heat	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
cellular response to hypoxia	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
cellular response to lead ion	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus.
cellular response to mechanical stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
cellular response to non-ionic osmotic stress	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of non-ionic solutes (e.g. mannitol, sorbitol) in the environment.
cellular response to UV	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
cyclooxygenase pathway	The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2.
decidualization	The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta.
embryo implantation	Attachment of the blastocyst to the uterine lining.
hair cycle	The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body.
inflammatory response	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
learning	Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
maintenance of blood-brain barrier	Maintaining the structure and function of the blood-brain barrier, thus ensuring specific regulated transport of substances (e.g. macromolecules, small molecules, ions) into the brain, and out of the brain into the blood circulation.
memory	The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
negative regulation of calcium ion transport	Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
negative regulation of cell cycle	Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
negative regulation of cell population proliferation	Any process that stops, prevents or reduces the rate or extent of cell proliferation.
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress	Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress.
negative regulation of smooth muscle contraction	Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction.
negative regulation of synaptic transmission, dopaminergic	Any process that stops, prevents, or reduces the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine.
ovulation	The release of a mature ovum/oocyte from an ovary.
positive regulation of apoptotic process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
positive regulation of brown fat cell differentiation	Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.
positive regulation of cell migration involved in sprouting angiogenesis	Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.
positive regulation of fever generation	Any process that activates or increases the frequency, rate, or extent of fever generation.
positive regulation of fibroblast growth factor production	Any process that increases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
positive regulation of nitric oxide biosynthetic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
positive regulation of peptidyl-serine phosphorylation	Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
positive regulation of platelet-derived growth factor production	Any process that increases the rate, frequency, or extent of the appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
positive regulation of prostaglandin biosynthetic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.
positive regulation of protein import into nucleus	Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
positive regulation of smooth muscle cell proliferation	Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
positive regulation of smooth muscle contraction	Any process that activates or increases the frequency, rate or extent of smooth muscle contraction.
positive regulation of synaptic plasticity	A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
positive regulation of synaptic transmission, glutamatergic	Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.
positive regulation of transforming growth factor beta production	Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta.
positive regulation of vascular endothelial growth factor production	Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor.
positive regulation of vasoconstriction	Any process that activates or increases the frequency, rate or extent of vasoconstriction.
prostaglandin biosynthetic process	The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring.
prostaglandin secretion	The regulated release of a prostaglandin, any of a group of biologically active metabolites which contain a cyclopentane ring, from a cell or a tissue.
regulation of blood pressure	Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
regulation of inflammatory response	Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
regulation of neuroinflammatory response	Any process that modulates the frequency, rate or extent of neuroinflammatory response.
response to angiotensin	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen.
response to estradiol	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
response to fatty acid	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus.
response to fructose	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus.
response to glucocorticoid	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
response to lipopolysaccharide	Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
response to lithium ion	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus.
response to manganese ion	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus.
response to nematode	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a nematode.
response to oxidative stress	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
response to tumor necrosis factor	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
response to vitamin D	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus.
response to xenobiotic stimulus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
sensory perception of pain	The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.

7 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O62664	PTGS1	Prostaglandin G/H synthase 1	Bos taurus (Bovine)	PR
Q8HZR1	PTGS1	Prostaglandin G/H synthase 1	Canis lupus familiaris (Dog) (Canis familiaris)	PR
Q9UPX0	IGSF9B	Protein turtle homolog B	Homo sapiens (Human)	PR
P23219	PTGS1	Prostaglandin G/H synthase 1	Homo sapiens (Human)	PR
P22437	Ptgs1	Prostaglandin G/H synthase 1	Mus musculus (Mouse)	PR
Q05769	Ptgs2	Prostaglandin G/H synthase 2	Mus musculus (Mouse)	PR
Q9C9U3	DOX2	Alpha-dioxygenase 2	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MLARALLLCA	VLALSHTANP	CCSHPCQNRG	VCMSVGFDQY	KCDCTRTGFY	GENCSTPEFL
70	80	90	100	110	120
TRIKLFLKPT	PNTVHYILTH	FKGFWNVVNN	IPFLRNAIMS	YVLTSRSHLI	DSPPTYNADY
130	140	150	160	170	180
GYKSWEAFSN	LSYYTRALPP	VPDDCPTPLG	VKGKKQLPDS	NEIVEKLLLR	RKFIPDPQGS
190	200	210	220	230	240
NMMFAFFAQH	FTHQFFKTDH	KRGPAFTNGL	GHGVDLNHIY	GETLARQRKL	RLFKDGKMKY
250	260	270	280	290	300
QIIDGEMYPP	TVKDTQAEMI	YPPQVPEHLR	FAVGQEVFGL	VPGLMMYATI	WLREHNRVCD
310	320	330	340	350	360
VLKQEHPEWG	DEQLFQTSRL	ILIGETIKIV	IEDYVQHLSG	YHFKLKFDPE	LLFNKQFQYQ
370	380	390	400	410	420
NRIAAEFNTL	YHWHPLLPDT	FQIHDQKYNY	QQFIYNNSIL	LEHGITQFVE	SFTRQIAGRV
430	440	450	460	470	480
AGGRNVPPAV	QKVSQASIDQ	SRQMKYQSFN	EYRKRFMLKP	YESFEELTGE	KEMSAELEAL
490	500	510	520	530	540
YGDIDAVELY	PALLVEKPRP	DAIFGETMVE	VGAPFSLKGL	MGNVICSPAY	WKPSTFGGEV
550	560	570	580	590	600
GFQIINTASI	QSLICNNVKG	CPFTSFSVPD	PELIKTVTIN	ASSSRSGLDD	INPTVLLKER

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