Q8H2D5
PR
Gene name |
POLH (RAD30, At5g44740, K23L20.8, T19K24.15) |
Protein name |
DNA polymerase eta |
Names |
Radiation-sensitive protein 30, AtRAD30, Y-family DNA polymerase H, AtPOLH |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G44740 |
EC number |
2.7.7.7: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8H2D5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8H2D5-F1 | Predicted | AlphaFoldDB |
113 variants for Q8H2D5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00707086 | 8 | A>T | No | 1000Genomes | |
| ENSVATH07335174 | 15 | A>V | No | 1000Genomes | |
| ENSVATH12521985 | 42 | V>I | No | 1000Genomes | |
| tmp_5_18051366_T_A | 45 | N>Y | No | 1000Genomes | |
| ENSVATH07335163 | 56 | S>R | No | 1000Genomes | |
| tmp_5_18051311_C_T | 63 | G>D | No | 1000Genomes | |
| tmp_5_18051198_C_G | 71 | D>H | No | 1000Genomes | |
| ENSVATH07335153 | 75 | A>T | No | 1000Genomes | |
| tmp_5_18051167_T_C | 81 | Q>R | No | 1000Genomes | |
| ENSVATH07335152 | 99 | S>G | No | 1000Genomes | |
| ENSVATH12521952 | 99 | S>N | No | 1000Genomes | |
| ENSVATH07335152 | 99 | S>R | No | 1000Genomes | |
| ENSVATH14589537 | 111 | S>I | No | 1000Genomes | |
| ENSVATH14589537 | 111 | S>T | No | 1000Genomes | |
| ENSVATH12521942 | 113 | K>R | No | 1000Genomes | |
| tmp_5_18050945_G_T | 124 | L>I | No | 1000Genomes | |
| ENSVATH12521941 | 125 | D>H | No | 1000Genomes | |
| tmp_5_18050894_T_C | 141 | S>G | No | 1000Genomes | |
| ENSVATH12521939 | 147 | E>G | No | 1000Genomes | |
| ENSVATH00707077 | 158 | N>S | No | 1000Genomes | |
| ENSVATH03353169 | 170 | R>L | No | 1000Genomes | |
| ENSVATH03353169 | 170 | R>P | No | 1000Genomes | |
| ENSVATH00707076 | 171 | N>D | No | 1000Genomes | |
| ENSVATH12521893 | 174 | C>F | No | 1000Genomes | |
| tmp_5_18050703_T_A | 176 | E>D | No | 1000Genomes | |
| tmp_5_18050621_C_T | 204 | E>K | No | 1000Genomes | |
| tmp_5_18050603_C_A | 210 | G>C | No | 1000Genomes | |
| ENSVATH12521891 | 233 | V>I | No | 1000Genomes | |
| tmp_5_18050441_T_A | 239 | Q>L | No | 1000Genomes | |
| ENSVATH03353154 | 240 | E>G | No | 1000Genomes | |
| ENSVATH14589536 | 263 | T>I | No | 1000Genomes | |
| ENSVATH00707066 | 267 | V>I | No | 1000Genomes | |
| ENSVATH07335135 | 268 | D>E | No | 1000Genomes | |
| ENSVATH03353133 | 271 | G>A | No | 1000Genomes | |
| ENSVATH12521862 | 277 | S>C | No | 1000Genomes | |
| tmp_5_18050070_G_A | 284 | H>Y | No | 1000Genomes | |
| ENSVATH00707065 | 285 | Y>F | No | 1000Genomes | |
| tmp_5_18049798_G_A | 308 | R>C | No | 1000Genomes | |
| tmp_5_18049788_G_A | 311 | P>L | No | 1000Genomes | |
| tmp_5_18049782_C_G | 313 | S>T | No | 1000Genomes | |
| ENSVATH12521856 | 324 | R>H | No | 1000Genomes | |
| ENSVATH00707055 | 344 | S>N | No | 1000Genomes | |
| ENSVATH00707054 | 348 | G>S | No | 1000Genomes | |
| ENSVATH00707053 | 349 | S>F | No | 1000Genomes | |
| ENSVATH00707052 | 366 | S>T | No | 1000Genomes | |
| tmp_5_18049421_C_T | 369 | R>K | No | 1000Genomes | |
| ENSVATH12521818 | 371 | K>N | No | 1000Genomes | |
| tmp_5_18049332_C_T | 372 | D>N | No | 1000Genomes | |
| ENSVATH00707050 | 386 | M>L | No | 1000Genomes | |
| tmp_5_18049239_C_T | 403 | A>T | No | 1000Genomes | |
| ENSVATH07335123 | 410 | G>V | No | 1000Genomes | |
| tmp_5_18049214_G_C | 411 | S>C | No | 1000Genomes | |
| ENSVATH03353095 | 412 | F>C | No | 1000Genomes | |
| ENSVATH07335122 | 412 | F>V | No | 1000Genomes | |
| ENSVATH03353094 | 413 | G>R | No | 1000Genomes | |
| ENSVATH00707048 | 416 | P>H | No | 1000Genomes | |
| ENSVATH12521816 | 419 | N>I | No | 1000Genomes | |
| ENSVATH00707047 | 423 | T>A | No | 1000Genomes | |
| ENSVATH00707046 | 438 | D>G | No | 1000Genomes | |
| ENSVATH07335121 | 439 | I>L | No | 1000Genomes | |
| tmp_5_18049016_G_A | 443 | T>I | No | 1000Genomes | |
| ENSVATH03353088 | 444 | S>C | No | 1000Genomes | |
| tmp_5_18048990_T_A | 452 | S>C | No | 1000Genomes | |
| tmp_5_18048989_C_T | 452 | S>N | No | 1000Genomes | |
| ENSVATH00707041 | 464 | C>Y | No | 1000Genomes | |
| ENSVATH00707040 | 467 | G>E | No | 1000Genomes | |
| ENSVATH00707039 | 473 | A>P | No | 1000Genomes | |
| ENSVATH03353077 | 477 | E>V | No | 1000Genomes | |
| ENSVATH03353076 | 483 | R>K | No | 1000Genomes | |
| ENSVATH03353074 | 490 | A>V | No | 1000Genomes | |
| ENSVATH00707033 | 494 | V>E | No | 1000Genomes | |
| ENSVATH14589513 | 497 | G>C | No | 1000Genomes | |
| tmp_5_18048746_G_A | 503 | P>S | No | 1000Genomes | |
| ENSVATH03353072 | 507 | N>D | No | 1000Genomes | |
| ENSVATH07335114 | 508 | Q>H | No | 1000Genomes | |
| ENSVATH00707030 | 508 | Q>P | No | 1000Genomes | |
| ENSVATH07335113 | 509 | D>N | No | 1000Genomes | |
| ENSVATH07335112 | 511 | D>G | No | 1000Genomes | |
| ENSVATH03353071 | 517 | E>K | No | 1000Genomes | |
| ENSVATH03353056 | 521 | V>L | No | 1000Genomes | |
| ENSVATH03353055 | 522 | S>C | No | 1000Genomes | |
| ENSVATH03353055 | 522 | S>F | No | 1000Genomes | |
| ENSVATH03353053 | 530 | D>E | No | 1000Genomes | |
| tmp_5_18048395_G_A | 535 | S>L | No | 1000Genomes | |
| tmp_5_18048393_C_T | 536 | E>K | No | 1000Genomes | |
| ENSVATH14589510 | 537 | S>L | No | 1000Genomes | |
| ENSVATH12521724 | 539 | K>R | No | 1000Genomes | |
| ENSVATH07335104 | 543 | T>I | No | 1000Genomes | |
| ENSVATH00707020 | 545 | K>R | No | 1000Genomes | |
| ENSVATH00707018 | 558 | R>L | No | 1000Genomes | |
| ENSVATH00707018 | 558 | R>Q | No | 1000Genomes | |
| ENSVATH07335101 | 558 | R>W | No | 1000Genomes | |
| ENSVATH00707014 | 564 | V>F | No | 1000Genomes | |
| ENSVATH00707014 | 564 | V>I | No | 1000Genomes | |
| ENSVATH03353042 | 569 | N>K | No | 1000Genomes | |
| tmp_5_18048162_G_A | 587 | S>L | No | 1000Genomes | |
| ENSVATH03353040 | 592 | R>I | No | 1000Genomes | |
| ENSVATH03353039 | 595 | L>F | No | 1000Genomes | |
| ENSVATH03353038 | 601 | N>T | No | 1000Genomes | |
| ENSVATH12521720 | 602 | S>R | No | 1000Genomes | |
| ENSVATH03353037 | 609 | E>D | No | 1000Genomes | |
| tmp_5_18048092_C_A | 610 | E>D | No | 1000Genomes | |
| ENSVATH03353036 | 611 | S>R | No | 1000Genomes | |
| ENSVATH12521719 | 617 | G>E | No | 1000Genomes | |
| tmp_5_18048047_C_A | 625 | Q>H | No | 1000Genomes | |
| tmp_5_18048012_C_T | 637 | R>Q | No | 1000Genomes | |
| ENSVATH07335099 | 639 | L>V | No | 1000Genomes | |
| tmp_5_18048001_T_A | 641 | S>C | No | 1000Genomes | |
| ENSVATH03353035 | 641 | S>N | No | 1000Genomes | |
| ENSVATH03353034 | 642 | F>V | No | 1000Genomes | |
| ENSVATH07335098 | 644 | R>C | No | 1000Genomes | |
| ENSVATH03353033 | 647 | K>T | No | 1000Genomes | |
| ENSVATH03353031 | 665 | H>Y | No | 1000Genomes |
No associated diseases with Q8H2D5
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.7 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| replication fork | The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. |
| site of double-strand break | A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| damaged DNA binding | Binding to damaged DNA. |
| DNA-directed DNA polymerase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. |
| metal ion binding | Binding to a metal ion. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. |
| error-prone translesion synthesis | The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites. |
| response to radiation | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. |
| response to UV-B | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm. |
| UV protection | Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPVARPEASD | ARVIAHVDMD | CFYVQVEQRK | QPELRGLPSA | VVQYNEWQGG | GLIAVSYEAR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KCGVKRSMRG | DEAKAACPQI | QLVQVPVARG | KADLNLYRSA | GSEVVSILAK | SGKCERASID |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EVYLDLTDAA | ESMLADAPPE | SLELIDEEVL | KSHILGMNRE | DGDDFKESVR | NWICREDADR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RDKLLSCGII | IVAELRKQVL | KETEFTCSAG | IAHNKMLAKL | ASGMNKPAQQ | TVVPYAAVQE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LLSSLPIKKM | KQLGGKLGTS | LQTDLGVDTV | GDLLQFSETK | LQEHYGVNTG | TWLWNIARGI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SGEEVQGRLL | PKSHGSGKTF | PGPRALKSLS | TVQHWLNQLS | EELSERLGSD | LEQNKRIAST |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LTLHASAFRS | KDSDSHKKFP | SKSCPMRYGV | TKIQEDAFNL | FQAALREYMG | SFGIKPQGNK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LETWRITGLS | VSASKIVDIP | SGTSSIMRYF | QSQPTVPSRS | ADGCVQGNVA | MTASASEGCS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EQRSTETQAA | MPEVDTGVTY | TLPNFENQDK | DIDLVSEKDV | VSCPSNEATD | VSTQSESNKG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TQTKKIGRKM | NNSKEKNRGM | PSIVDIFKNY | NATPPSKQET | QEDSTVSSAS | KRAKLSSSSH |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NSQVNQEVEE | SRETDWGYKT | DEIDQSVFDE | LPVEIQRELR | SFLRTNKQFN | TGKSKGDGST |
| 670 | |||||
| SSIAHYFPPL | NR |