AiPD: Autoinhibited Protein Database

Gene name	Aldh4a1
Protein name	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
Names	P5C dehydrogenase, Aldehyde dehydrogenase family 4 member A1, L-glutamate gamma-semialdehyde dehydrogenase
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:212647
EC number	1.2.1.88: With NAD(+) or NADP(+) as acceptor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

484-561 (Predicted disordered autoinhibitory region) PR

484-561 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
3V9J	X-ray	130 A	A/B	21-562	PDB
3V9K	X-ray	150 A	A/B	21-562	PDB
3V9L	X-ray	150 A	A/B	21-562	PDB
4E3X	X-ray	124 A	A/B	21-562	PDB
4LGZ	X-ray	168 A	A/B	21-562	PDB
4LH0	X-ray	167 A	A/B	21-562	PDB
4LH1	X-ray	167 A	A/B	21-562	PDB
4LH2	X-ray	167 A	A/B	21-562	PDB
4LH3	X-ray	181 A	A/B	21-562	PDB
7MER	X-ray	174 A	A/B	21-562	PDB
7MES	X-ray	137 A	A/B	21-562	PDB
AF-Q8CHT0-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs234634229	5	P>L	No	EVA
rs234634229	5	P>Q	No	EVA
rs3388726000	5	P>S	No	EVA
rs3388731676	10	S>P	No	EVA
rs244417427	18	G>S	No	EVA
rs213268094	32	T>A	No	EVA
rs3394986497	40	S>C	No	EVA
rs3388714469	48	A>P	No	EVA
rs27613234	60	M>T	No	EVA
rs262101234	76	D>N	No	EVA
rs3388726061	121	A>T	No	EVA
rs3388720264	162	A>T	No	EVA
rs229271876	193	H>Q	No	EVA
rs246569329	194	T>A	No	EVA
rs3388726071	198	G>E	No	EVA
rs3388731725	199	L>M	No	EVA
rs224904371	221	A>T	No	EVA
rs3394981825	294	W>*	No	EVA
rs3388718552	315	G>C	No	EVA
rs3388726997	347	C>S	No	EVA
rs3388723631	402	W>R	No	EVA
rs3388726404	415	L>M	No	EVA
rs3394986471	434	E>D	No	EVA
rs3388722225	443	M>L	No	EVA
rs3388726438	444	K>M	No	EVA
rs3388730883	461	K>E	No	EVA
rs243129912	467	Q>K	No	EVA
rs864305758	512	S>P	No	EVA
rs3388719853	520	G>R	No	EVA

Type	Name	Position	InterPro Accession
domain	Aldehyde dehydrogenase domain	81 - 544	IPR015590
conserved_site	Aldehyde dehydrogenase, cysteine active site	340 - 351	IPR016160
conserved_site	Aldehyde dehydrogenase, glutamic acid active site	312 - 319	IPR029510

		Description
EC Number	1.2.1.88	With NAD(+) or NADP(+) as acceptor
Subcellular Localization	Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrial matrix	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

Name	Definition
1-pyrroline-5-carboxylate dehydrogenase activity	Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+).
aldehyde dehydrogenase (NAD+) activity	Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
identical protein binding	Binding to an identical protein or proteins.

Name	Definition
proline catabolic process to glutamate	The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A7YWE4	ALDH4A1	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	Bos taurus (Bovine)	PR
P30038	ALDH4A1	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	Homo sapiens (Human)	PR
Q7SY23	aldh4a1	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	Danio rerio (Zebrafish) (Brachydanio rerio)	PR