A7YWE4
PR
Gene name |
ALDH4A1 |
Protein name |
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial |
Names |
P5C dehydrogenase, Aldehyde dehydrogenase family 4 member A1, L-glutamate gamma-semialdehyde dehydrogenase |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:100126042 |
EC number |
1.2.1.88: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A7YWE4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A7YWE4-F1 | Predicted | AlphaFoldDB |
358 variants for A7YWE4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs1116963333 | 2 | L>M | No | EVA | |
| rs517709428 | 25 | R>K | No | EVA | |
| rs462879492 | 26 | C>G | No | EVA | |
| rs478157340 | 26 | C>W | No | EVA | |
| rs522734015 | 26 | C>Y | No | EVA | |
| rs526327423 | 27 | V>I | No | EVA | |
| rs466206673 | 28 | S>F | No | EVA | |
| rs445304622 | 28 | S>P | No | EVA | |
| rs434803668 | 32 | V>A | No | EVA | |
| rs451595521 | 34 | N>Y | No | EVA | |
| rs443879635 | 54 | L>M | No | EVA | |
| rs477745023 | 59 | G>D | No | EVA | |
| rs209409749 | 60 | R>Q | No | EVA | |
| rs481072885 | 64 | I>S | No | EVA | |
| rs459240125 | 64 | I>V | No | EVA | |
| rs469926236 | 73 | V>G | No | EVA | |
| rs464286024 | 78 | V>E | No | EVA | |
| rs434598136 | 79 | R>L | No | EVA | |
| rs434598136 | 79 | R>Q | No | EVA | |
| rs432024513 | 86 | N>H | No | EVA | |
| rs465897551 | 88 | G>A | No | EVA | |
| rs436897058 | 95 | C>F | No | EVA | |
| rs468745479 | 101 | L>V | No | EVA | |
| rs439260017 | 109 | A>P | No | EVA | |
| rs439260017 | 109 | A>T | No | EVA | |
| rs473215874 | 110 | L>F | No | EVA | |
| rs451321798 | 110 | L>M | No | EVA | |
| rs451321798 | 110 | L>V | No | EVA | |
| rs440237768 | 113 | R>M | No | EVA | |
| rs462039055 | 116 | W>C | No | EVA | |
| rs480468563 | 120 | P>A | No | EVA | |
| rs444357624 | 121 | V>M | No | EVA | |
| rs463715657 | 122 | A>T | No | EVA | |
| rs482298382 | 123 | D>G | No | EVA | |
| rs446101036 | 124 | R>L | No | EVA | |
| rs464654953 | 125 | A>G | No | EVA | |
| rs447049590 | 127 | V>G | No | EVA | |
| rs435808492 | 132 | A>D | No | EVA | |
| rs468981890 | 133 | D>A | No | EVA | |
| rs432813698 | 134 | L>R | No | EVA | |
| rs473127669 | 135 | L>V | No | EVA | |
| rs43315859 | 136 | S>R | No | EVA | |
| rs440093685 | 136 | S>T | No | EVA | |
| rs474006838 | 137 | G>R | No | EVA | |
| rs439629326 | 139 | R>P | No | EVA | |
| rs475833176 | 139 | R>S | No | EVA | |
| rs479916067 | 141 | A>V | No | EVA | |
| rs446908599 | 142 | E>A | No | EVA | |
| rs462155726 | 143 | V>G | No | EVA | |
| rs469704697 | 149 | V>G | No | EVA | |
| rs481480000 | 155 | V>A | No | EVA | |
| rs481480000 | 155 | V>G | No | EVA | |
| rs448508820 | 157 | Q>K | No | EVA | |
| rs437420675 | 161 | D>A | No | EVA | |
| rs437420675 | 161 | D>G | No | EVA | |
| rs435054378 | 163 | A>G | No | EVA | |
| rs464869366 | 163 | A>P | No | EVA | |
| rs452749016 | 164 | A>D | No | EVA | |
| rs474424841 | 165 | E>G | No | EVA | |
| rs441637259 | 166 | L>I | No | EVA | |
| rs457003210 | 167 | I>S | No | EVA | |
| rs475629825 | 168 | D>N | No | EVA | |
| rs439426835 | 169 | F>C | No | EVA | |
| rs457946028 | 172 | F>C | No | EVA | |
| rs479667459 | 173 | N>H | No | EVA | |
| rs459713164 | 177 | A>D | No | EVA | |
| rs470316992 | 178 | M>I | No | EVA | |
| rs110857310 | 178 | M>L | No | EVA | |
| rs448553534 | 178 | M>R | No | EVA | |
| rs110857310 | 178 | M>V | No | EVA | |
| rs482471300 | 180 | L>P | No | EVA | |
| rs446151513 | 182 | G>D | No | EVA | |
| rs435017526 | 187 | S>I | No | EVA | |
| rs447123437 | 190 | P>A | No | EVA | |
| rs467984846 | 193 | N>H | No | EVA | |
| rs468745546 | 202 | G>A | No | EVA | |
| rs450360402 | 203 | F>V | No | EVA | |
| rs469018677 | 204 | V>A | No | EVA | |
| rs432852502 | 205 | A>T | No | EVA | |
| rs433805243 | 208 | S>P | No | EVA | |
| rs444328576 | 211 | N>D | No | EVA | |
| rs463681869 | 211 | N>K | No | EVA | |
| rs475870400 | 212 | F>L | No | EVA | |
| rs439219766 | 213 | T>I | No | EVA | |
| rs479808759 | 214 | A>E | No | EVA | |
| rs458111830 | 214 | A>S | No | EVA | |
| rs462192651 | 215 | I>L | No | EVA | |
| rs480942812 | 215 | I>S | No | EVA | |
| rs468929992 | 218 | N>H | No | EVA | |
| rs477879012 | 219 | L>P | No | EVA | |
| rs433668088 | 222 | A>D | No | EVA | |
| rs467603704 | 223 | P>R | No | EVA | |
| rs454279584 | 227 | G>R | No | EVA | |
| rs436667778 | 229 | V>E | No | EVA | |
| rs436667778 | 229 | V>G | No | EVA | |
| rs466382133 | 229 | V>L | No | EVA | |
| rs455179331 | 230 | V>A | No | EVA | |
| rs476240569 | 232 | W>G | No | EVA | |
| rs443245528 | 234 | P>R | No | EVA | |
| rs451996336 | 235 | S>R | No | EVA | |
| rs470469554 | 236 | D>A | No | EVA | |
| rs440886370 | 238 | A>G | No | EVA | |
| rs459358690 | 239 | M>L | No | EVA | |
| rs481300677 | 241 | A>D | No | EVA | |
| rs463657468 | 243 | Y>* | No | EVA | |
| rs441887864 | 243 | Y>C | No | EVA | |
| rs483062069 | 244 | A>D | No | EVA | |
| rs450057437 | 245 | V>A | No | EVA | |
| rs465373153 | 246 | Y>C | No | EVA | |
| rs447804533 | 248 | I>L | No | EVA | |
| rs466351409 | 248 | I>S | No | EVA | |
| rs466351409 | 248 | I>T | No | EVA | |
| rs436622242 | 249 | L>P | No | EVA | |
| rs436622242 | 249 | L>R | No | EVA | |
| rs455221910 | 250 | R>G | No | EVA | |
| rs437503993 | 251 | E>G | No | EVA | |
| rs470428312 | 251 | E>K | No | EVA | |
| rs451959456 | 254 | L>R | No | EVA | |
| rs440849589 | 257 | N>Y | No | EVA | |
| rs452921526 | 265 | D>A | No | EVA | |
| rs3423149520 | 268 | T>N | No | EVA | |
| rs441839376 | 268 | T>P | No | EVA | |
| rs475667572 | 271 | D>A | No | EVA | |
| rs475667572 | 271 | D>G | No | EVA | |
| rs463567681 | 271 | D>H | No | EVA | |
| rs458903024 | 275 | S>R | No | EVA | |
| rs477434228 | 275 | S>T | No | EVA | |
| rs459841596 | 278 | H>P | No | EVA | |
| rs459841596 | 278 | H>R | No | EVA | |
| rs481567288 | 279 | L>P | No | EVA | |
| rs448541670 | 280 | C>F | No | EVA | |
| rs470415586 | 280 | C>W | No | EVA | |
| rs437427521 | 285 | T>A | No | EVA | |
| rs446328535 | 286 | G>A | No | EVA | |
| rs477541684 | 299 | A>G | No | EVA | |
| rs447748794 | 300 | Q>K | No | EVA | |
| rs466405921 | 301 | N>T | No | EVA | |
| rs448800127 | 307 | T>P | No | EVA | |
| rs469598783 | 307 | T>S | No | EVA | |
| rs436803762 | 308 | F>C | No | EVA | |
| rs436803762 | 308 | F>S | No | EVA | |
| rs465600733 | 315 | C>G | No | EVA | |
| rs465600733 | 315 | C>R | No | EVA | |
| rs465600733 | 315 | C>S | No | EVA | |
| rs432657078 | 316 | G>A | No | EVA | |
| rs465717442 | 318 | K>E | No | EVA | |
| rs465717442 | 318 | K>Q | No | EVA | |
| rs435998541 | 319 | N>K | No | EVA | |
| rs469672275 | 321 | H>P | No | EVA | |
| rs436881299 | 323 | V>L | No | EVA | |
| rs436881299 | 323 | V>M | No | EVA | |
| rs452192259 | 324 | H>N | No | EVA | |
| rs470839442 | 324 | H>Q | No | EVA | |
| rs452192259 | 324 | H>Y | No | EVA | |
| rs474903141 | 328 | D>E | No | EVA | |
| rs453226156 | 328 | D>G | No | EVA | |
| rs441079973 | 328 | D>H | No | EVA | |
| rs442807265 | 329 | V>G | No | EVA | |
| rs461363691 | 330 | D>A | No | EVA | |
| rs483093160 | 330 | D>E | No | EVA | |
| rs443746576 | 331 | S>C | No | EVA | |
| rs459066489 | 331 | S>R | No | EVA | |
| rs443746576 | 331 | S>R | No | EVA | |
| rs447884343 | 332 | V>A | No | EVA | |
| rs447884343 | 332 | V>G | No | EVA | |
| rs477680815 | 332 | V>M | No | EVA | |
| rs466262140 | 333 | V>A | No | EVA | |
| rs466262140 | 333 | V>G | No | EVA | |
| rs481538038 | 334 | S>C | No | EVA | |
| rs481538038 | 334 | S>G | No | EVA | |
| rs447964352 | 334 | S>R | No | EVA | |
| rs469637466 | 336 | T>A | No | EVA | |
| rs469637466 | 336 | T>P | No | EVA | |
| rs436840500 | 337 | L>P | No | EVA | |
| rs436840500 | 337 | L>Q | No | EVA | |
| rs452217441 | 338 | R>C | No | EVA | |
| rs464319280 | 338 | R>L | No | EVA | |
| rs453043135 | 339 | S>L | No | EVA | |
| rs434531488 | 339 | S>P | No | EVA | |
| rs453043135 | 339 | S>W | No | EVA | |
| rs441962950 | 340 | A>P | No | EVA | |
| rs476639861 | 342 | E>D | No | EVA | |
| rs454901359 | 342 | E>K | No | EVA | |
| rs459094728 | 343 | Y>* | No | EVA | |
| rs443688730 | 343 | Y>S | No | EVA | |
| rs441365365 | 346 | Q>E | No | EVA | |
| rs441365365 | 346 | Q>K | No | EVA | |
| rs459800109 | 346 | Q>L | No | EVA | |
| rs481497503 | 347 | K>M | No | EVA | |
| rs448728362 | 347 | K>N | No | EVA | |
| rs481497503 | 347 | K>T | No | EVA | |
| rs469600493 | 348 | C>G | No | EVA | |
| rs481915676 | 348 | C>S | No | EVA | |
| rs464221035 | 349 | S>A | No | EVA | |
| rs446608254 | 350 | A>G | No | EVA | |
| rs435467491 | 351 | C>G | No | EVA | |
| rs435467491 | 351 | C>R | No | EVA | |
| rs135789179 | 352 | S>A | No | EVA | |
| rs135789179 | 352 | S>P | No | EVA | |
| rs437142238 | 353 | R>S | No | EVA | |
| rs471078106 | 355 | Y>S | No | EVA | |
| rs441317106 | 356 | A>E | No | EVA | |
| rs475048943 | 357 | P>R | No | EVA | |
| rs463842897 | 358 | R>H | No | EVA | |
| rs482592930 | 359 | S>* | No | EVA | |
| rs445591552 | 360 | L>Q | No | EVA | |
| rs445591552 | 360 | L>R | No | EVA | |
| rs457687782 | 362 | P>A | No | EVA | |
| rs446593083 | 364 | I>S | No | EVA | |
| rs446593083 | 364 | I>T | No | EVA | |
| rs468363763 | 365 | K>Q | No | EVA | |
| rs435428189 | 366 | G>R | No | EVA | |
| rs450724745 | 370 | E>A | No | EVA | |
| rs452459185 | 371 | E>D | No | EVA | |
| rs433096995 | 371 | E>G | No | EVA | |
| rs469265788 | 371 | E>K | No | EVA | |
| rs434865008 | 375 | I>V | No | EVA | |
| rs453329568 | 376 | K>N | No | EVA | |
| rs474911966 | 377 | V>E | No | EVA | |
| rs474911966 | 377 | V>G | No | EVA | |
| rs463804020 | 379 | N>K | No | EVA | |
| rs473830658 | 380 | P>T | No | EVA | |
| rs444139017 | 381 | A>E | No | EVA | |
| rs462576920 | 382 | E>K | No | EVA | |
| rs471513789 | 383 | D>E | No | EVA | |
| rs438548005 | 392 | I>N | No | EVA | |
| rs450672361 | 396 | S>A | No | EVA | |
| rs450672361 | 396 | S>P | No | EVA | |
| rs521574646 | 398 | G>D | No | EVA | |
| rs445981333 | 399 | R>S | No | EVA | |
| rs464426370 | 400 | I>L | No | EVA | |
| rs434837948 | 403 | W>C | No | EVA | |
| rs468701622 | 404 | L>P | No | EVA | |
| rs468701622 | 404 | L>R | No | EVA | |
| rs133024962 | 405 | E>A | No | EVA | |
| rs133024962 | 405 | E>G | No | EVA | |
| rs457555180 | 406 | H>N | No | EVA | |
| rs476079244 | 406 | H>Q | No | EVA | |
| rs457555180 | 406 | H>Y | No | EVA | |
| rs433489235 | 408 | R>P | No | EVA | |
| rs440130994 | 412 | S>R | No | EVA | |
| rs461795136 | 413 | L>P | No | EVA | |
| rs473939945 | 414 | T>P | No | EVA | |
| rs444160309 | 415 | I>L | No | EVA | |
| rs462778132 | 416 | L>R | No | EVA | |
| rs715215785 | 420 | H>Q | No | EVA | |
| rs478136201 | 424 | S>P | No | EVA | |
| rs457974945 | 425 | V>A | No | EVA | |
| rs445138936 | 425 | V>L | No | EVA | |
| rs479567927 | 432 | C>R | No | EVA | |
| rs446808656 | 433 | I>L | No | EVA | |
| rs468616854 | 434 | V>A | No | EVA | |
| rs435706570 | 435 | E>A | No | EVA | |
| rs450974563 | 437 | K>R | No | EVA | |
| rs433452445 | 438 | D>A | No | EVA | |
| rs433452445 | 438 | D>G | No | EVA | |
| rs469637955 | 438 | D>Y | No | EVA | |
| rs473698048 | 441 | D>A | No | EVA | |
| rs433522711 | 446 | E>D | No | EVA | |
| rs460594485 | 447 | E>G | No | EVA | |
| rs472693487 | 448 | I>V | No | EVA | |
| rs442984258 | 449 | F>V | No | EVA | |
| rs461536351 | 450 | G>R | No | EVA | |
| rs450339353 | 452 | V>L | No | EVA | |
| rs476761437 | 454 | A>G | No | EVA | |
| rs447215150 | 455 | V>G | No | EVA | |
| rs136347201 | 456 | Y>* | No | EVA | |
| rs134676230 | 456 | Y>D | No | EVA | |
| rs465667066 | 456 | Y>S | No | EVA | |
| rs448248777 | 461 | E>G | No | EVA | |
| rs470006884 | 463 | Y>N | No | EVA | |
| rs437082676 | 464 | K>Q | No | EVA | |
| rs470890167 | 467 | L>M | No | EVA | |
| rs454146307 | 469 | L>M | No | EVA | |
| rs454146307 | 469 | L>V | No | EVA | |
| rs454912523 | 470 | V>D | No | EVA | |
| rs454912523 | 470 | V>G | No | EVA | |
| rs442930783 | 470 | V>I | No | EVA | |
| rs459043375 | 471 | D>E | No | EVA | |
| rs443800789 | 471 | D>N | No | EVA | |
| rs477523855 | 472 | S>G | No | EVA | |
| rs440741308 | 472 | S>N | No | EVA | |
| rs459310105 | 472 | S>R | No | EVA | |
| rs440741308 | 472 | S>T | No | EVA | |
| rs481148077 | 473 | T>P | No | EVA | |
| rs481148077 | 473 | T>S | No | EVA | |
| rs448130166 | 474 | T>P | No | EVA | |
| rs469899819 | 475 | S>G | No | EVA | |
| rs469899819 | 475 | S>R | No | EVA | |
| rs445849249 | 476 | Y>* | No | EVA | |
| rs481974077 | 476 | Y>H | No | EVA | |
| rs464486296 | 477 | G>R | No | EVA | |
| rs454140298 | 478 | L>F | No | EVA | |
| rs454988271 | 479 | T>M | No | EVA | |
| rs436495357 | 479 | T>P | No | EVA | |
| rs443829300 | 480 | G>V | No | EVA | |
| rs471127651 | 481 | A>G | No | EVA | |
| rs481127450 | 482 | V>G | No | EVA | |
| rs459354022 | 482 | V>L | No | EVA | |
| rs441596499 | 483 | F>S | No | EVA | |
| rs463456745 | 484 | A>S | No | EVA | |
| rs481894593 | 485 | Q>P | No | EVA | |
| rs445886174 | 486 | D>G | No | EVA | |
| rs474075284 | 488 | D>N | No | EVA | |
| rs444184697 | 488 | D>V | No | EVA | |
| rs462720526 | 489 | V>F | No | EVA | |
| rs477887560 | 493 | A>V | No | EVA | |
| rs439586114 | 496 | L>R | No | EVA | |
| rs479973753 | 500 | A>P | No | EVA | |
| rs446893001 | 500 | A>V | No | EVA | |
| rs468647477 | 501 | A>S | No | EVA | |
| rs480892693 | 502 | G>C | No | EVA | |
| rs451102359 | 506 | I>V | No | EVA | |
| rs433428268 | 507 | N>K | No | EVA | |
| rs469701842 | 507 | N>T | No | EVA | |
| rs134165056 | 514 | V>G | No | EVA | |
| rs433671009 | 515 | V>A | No | EVA | |
| rs433671009 | 515 | V>G | No | EVA | |
| rs444228040 | 517 | Q>H | No | EVA | |
| rs473889720 | 517 | Q>P | No | EVA | |
| rs456150082 | 518 | Q>E | No | EVA | |
| rs137637124 | 518 | Q>P | No | EVA | |
| rs438621326 | 520 | F>L | No | EVA | |
| rs457982938 | 521 | G>R | No | EVA | |
| rs462285518 | 522 | G>A | No | EVA | |
| rs440384778 | 522 | G>C | No | EVA | |
| rs451137433 | 523 | A>P | No | EVA | |
| rs478510454 | 524 | R>* | No | EVA | |
| rs458376255 | 529 | N>T | No | EVA | |
| rs481133988 | 534 | G>A | No | EVA | |
| rs448307417 | 535 | P>H | No | EVA | |
| rs482121474 | 537 | Y>* | No | EVA | |
| rs517751438 | 538 | V>I | No | EVA | |
| rs464454159 | 541 | W>R | No | EVA | |
| rs447627967 | 542 | T>M | No | EVA | |
| rs432409738 | 542 | T>P | No | EVA | |
| rs436456708 | 543 | S>P | No | EVA | |
| rs436456708 | 543 | S>T | No | EVA | |
| rs454983451 | 545 | Q>H | No | EVA | |
| rs476562621 | 546 | V>F | No | EVA | |
| rs437352137 | 548 | K>E | No | EVA | |
| rs452730411 | 549 | E>K | No | EVA | |
| rs471286659 | 550 | T>P | No | EVA | |
| rs440818087 | 551 | H>R | No | EVA | |
| rs522737325 | 552 | G>R | No | EVA | |
| rs441695183 | 554 | L>R | No | EVA | |
| rs474722893 | 554 | L>V | No | EVA | |
| rs463447563 | 555 | G>V | No | EVA | |
| rs482057715 | 556 | D>Y | No | EVA | |
| rs445849305 | 557 | W>G | No | EVA | |
| rs457994518 | 557 | W>L | No | EVA | |
| rs479727900 | 558 | R>S | No | EVA | |
| rs466144125 | 559 | Y>S | No | EVA | |
| rs436457525 | 560 | P>R | No | EVA | |
| rs470097419 | 561 | Y>* | No | EVA | |
| rs448536496 | 561 | Y>N | No | EVA | |
| rs437390744 | 564 | Q>G | No | EVA | |
| rs437390744 | 564 | Q>R | No | EVA |
No associated diseases with A7YWE4
No regional properties for A7YWE4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for A7YWE4 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 1.2.1.88 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1-pyrroline-5-carboxylate dehydrogenase activity | Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| proline catabolic process to glutamate | The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P30038 | ALDH4A1 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | Homo sapiens (Human) | PR |
| Q8CHT0 | Aldh4a1 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | Mus musculus (Mouse) | PR |
| Q7SY23 | aldh4a1 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLLRSAALCR | ALLARRGRAA | GLCRRCVSSL | QVANEPVLAF | TQGSPERDAL | QKALKELKGR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TEAIPCVVGD | EEVWTSDVRY | QASPFNHGHK | VAKFCYADKA | LLHRAIGAAL | AARKEWDLKP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VADRAQVFLK | AADLLSGPRR | AEVLAKTMVG | QGKTVIQAEI | DAAAELIDFF | RFNAKFAMEL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EGEQPLSVPP | STNSMLYRGL | EGFVAAISPF | NFTAIGGNLA | GAPALMGNVV | LWKPSDTAML |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ASYAVYRILR | EAGLPPNIIQ | FVPADGPTFG | DTVTSSEHLC | GINFTGSVPT | FKHLWKQVAQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NLDRFRTFPR | LAGECGGKNF | HFVHRSADVD | SVVSGTLRSA | FEYGGQKCSA | CSRLYAPRSL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| WPQIKGRLLE | ELGGIKVGNP | AEDFGTFFSA | VIDAKSFGRI | RKWLEHARSS | PSLTILAGGH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| CDDSVGYFVE | PCIVETKDPQ | DPIMKEEIFG | PVLAVYVYPD | EEYKETLRLV | DSTTSYGLTG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| AVFAQDKDVL | REATELLRHA | AGNFYINDKS | TGSVVGQQPF | GGARASGTND | KPGGPHYVLR |
| 550 | 560 | ||||
| WTSPQVIKET | HGPLGDWRYP | YMQ |