Q7SY23
Gene name |
aldh4a1 (zgc:63592) |
Protein name |
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial |
Names |
P5C dehydrogenase, Aldehyde dehydrogenase family 4 member A1, L-glutamate gamma-semialdehyde dehydrogenase |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:394133 |
EC number |
1.2.1.88: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q7SY23
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7SY23-F1 | Predicted | AlphaFoldDB |
No variants for Q7SY23
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q7SY23 | |||||
No associated diseases with Q7SY23
No regional properties for Q7SY23
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q7SY23 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 1.2.1.88 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1-pyrroline-5-carboxylate dehydrogenase activity | Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| proline catabolic process to glutamate | The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A7YWE4 | ALDH4A1 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | Bos taurus (Bovine) | PR |
| P30038 | ALDH4A1 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | Homo sapiens (Human) | PR |
| Q8CHT0 | Aldh4a1 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLRARSAVSQ | SWKGFKTFSC | VAVEVKNEPV | LEFKEGSKER | AELEEALRNL | KGKTEEIPCV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IGNEEVWTKD | IRFQLSPFNH | SHQVAKFCYA | DKDLLNKAIE | ASVAARREWD | LKPVSDRAQI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FFKAADIISG | PKRAEVLAKT | MIGQGKTVVQ | AEIDAAPELI | DFFRFNAKHA | IELEDQQPLD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SDGSTNTMLY | RGLEGFVAAV | APFNFTAIGG | NLAGTPALMG | NVVLWKPSDT | AMSASYAVYK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ILRESGLPPN | IIQFVPADGP | VFGDTVTSSE | HLAGINFTGS | VPTFKRLWKQ | VAQNLDIYKN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FPRVAGECGG | KNFHFVHKSA | DVRSVVTGTI | RSAFEYGGQK | CSACSRMYVP | DSLWPQIRQG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LLDVYKQIKV | GDPVEDFSTF | FSAVIDDKSF | SRIKGWLEHA | RSSPHLKIIA | GGNCDDKKGY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FVEPTIIETT | DPQEKIMNEE | IFGPVLTVYV | YPENDYKKVL | HLIDNTSPYA | LTGAIFPQDK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SVIEEAGKAL | RNAAGNYYIN | DKSTGSIVAQ | QPFGGARASG | TNDKPGGPHY | VLRWTSPQVV |
| 550 | |||||
| KQTHVPLTEW | KYPYMS |