Q8CHP5
Gene name |
Pym1 |
Protein name |
Partner of Y14 and mago |
Names |
PYM homolog 1 exon junction complex-associated factor, Protein wibg homolog |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:78428 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8CHP5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8CHP5-F1 | Predicted | AlphaFoldDB |
13 variants for Q8CHP5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389141844 | 30 | R>W | No | EVA | |
| rs3389107990 | 56 | K>* | No | EVA | |
| rs3389145776 | 67 | A>G | No | EVA | |
| rs3389135028 | 76 | P>L | No | EVA | |
| rs3389137655 | 98 | R>W | No | EVA | |
| rs3389135042 | 101 | Q>* | No | EVA | |
| rs3389136552 | 117 | L>P | No | EVA | |
| rs3401837793 | 118 | G>R | No | EVA | |
| rs235873188 | 123 | I>M | No | EVA | |
| rs214874517 | 123 | I>T | No | EVA | |
| rs261314724 | 143 | S>P | No | EVA | |
| rs3389141847 | 164 | E>K | No | EVA | |
| rs3389124800 | 167 | Q>* | No | EVA |
No associated diseases with Q8CHP5
1 regional properties for Q8CHP5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | WIBG, Mago-binding | 12 - 38 | IPR015362 |
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell junction | A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| exon-exon junction complex | A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ribosome binding | Binding to a ribosome. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| exon-exon junction complex disassembly | The disaggregation of an exon-exon junction complex into its constituent components. |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. |
| positive regulation of translation | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| METASTPEAT | GTGKYIASTQ | RPDGTWRKQR | RVKEGYVPQE | EVPVYENKYV | KFFKSKPELP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PGLSPEATTP | VTPSRPEGGE | TGLSKTAKRN | LKRKEKRRQQ | QEKEAEALSR | TLDKVSLGDT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AQIPSALQGP | QATPLAASDP | SDSAATTEKA | KKIKNLRKKL | RQVEELQQRI | QAGEVSQPSR |
| 190 | 200 | ||||
| EQLEKLARRR | VLEEELEDLE | LGL |