Q6PH11

PR
Gene name
pym1
Protein name
Partner of Y14 and mago
Names
PYM homolog 1 exon junction complex-associated factor, Protein wibg homolog
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:393566
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

37-143 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6PH11

Entry ID Method Resolution Chain Position Source
AF-Q6PH11-F1 Predicted AlphaFoldDB

No variants for Q6PH11

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6PH11

No associated diseases with Q6PH11

1 regional properties for Q6PH11

Type Name Position InterPro Accession
domain WIBG, Mago-binding 10 - 36 IPR015362

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus, nucleolus
  • Nucleus, nucleoplasm
  • Shuttles between the nucleus and the cytoplasm
  • Nuclear export is mediated by XPO1/CRM1
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
exon-exon junction complex A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

2 GO annotations of molecular function

Name Definition
ribosome binding Binding to a ribosome.
RNA binding Binding to an RNA molecule or a portion thereof.

3 GO annotations of biological process

Name Definition
exon-exon junction complex disassembly The disaggregation of an exon-exon junction complex into its constituent components.
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
positive regulation of translation Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A6QPH1 PYM1 Partner of Y14 and mago Bos taurus (Bovine) PR
Q9BRP8 PYM1 Partner of Y14 and mago Homo sapiens (Human) PR
Q8CHP5 Pym1 Partner of Y14 and mago Mus musculus (Mouse) PR
10 20 30 40 50 60
MATPYVTDES GKYIAATQRP DGSWRKPRRV RDGYVPQEEV PVYENKFVKF FKSKPELPPG
70 80 90 100 110 120
VCVETPPQTQ TQPSDAAGLS RTAKRNMKRK EKRRQQGQET KSEPELQPEP ELQPEPEPQG
130 140 150 160 170 180
LSQQMQQLEL SASQGPGAAD SARRLKNLRK KLRQVEELQQ RVLSGELKPS QEQLDKLGRA
190
QALREELQQL EAHS