A6QPH1

PR
Gene name
PYM1
Protein name
Partner of Y14 and mago
Names
PYM homolog 1 exon junction complex-associated factor, Protein wibg homolog
Species
Bos taurus (Bovine)
KEGG Pathway
bta:787259
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-203 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6QPH1

Entry ID Method Resolution Chain Position Source
AF-A6QPH1-F1 Predicted AlphaFoldDB

63 variants for A6QPH1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs453918288 3 T>P No EVA
rs440546957 5 Y>* No EVA
rs474189386 6 V>G No EVA
rs455866904 6 V>I No EVA
rs444451184 7 T>A No EVA
rs444451184 7 T>P No EVA
rs444451184 7 T>S No EVA
rs463197610 7 T>S No EVA
rs438956351 8 D>A No EVA
rs460589695 8 D>E No EVA
rs479054606 10 T>P No EVA
rs479054606 10 T>S No EVA
rs460909269 11 G>A No EVA
rs471785913 44 Y>D No EVA
rs438996860 54 S>R No EVA
rs460047544 54 S>R No EVA
rs478515006 56 P>Q No EVA
rs448740093 57 E>D No EVA
rs460939409 59 P>S No EVA
rs460939409 59 P>T No EVA
rs449944046 66 A>G No EVA
rs482731769 66 A>P No EVA
rs447508076 69 P>A No EVA
rs467025539 71 T>P No EVA
rs434079854 72 A>P No EVA
rs438016196 88 R>H No EVA
rs456803447 89 N>H No EVA
rs471921280 89 N>T No EVA
rs454186793 102 K>E No EVA
rs472645899 104 E>D No EVA
rs211284454 105 A>G No EVA
rs211284454 105 A>V No EVA
rs482653650 109 S>G No EVA
rs443210689 110 R>L No EVA
rs718747117 110 R>W No EVA
rs447445189 112 L>P No EVA
rs449348038 117 L>P No EVA
rs467878085 120 T>P No EVA
rs465458364 123 V>A No EVA
rs465458364 123 V>G No EVA
rs456472515 123 V>I No EVA
rs432639496 125 S>R No EVA
rs454323003 126 A>S No EVA
rs443028789 128 Q>L No EVA
rs476326183 130 S>P No EVA
rs459670202 136 A>P No EVA
rs481248202 138 S>A No EVA
rs448201826 139 D>V No EVA
rs483197158 142 D>A No EVA
rs483197158 142 D>G No EVA
rs461424827 142 D>Y No EVA
rs450135889 147 T>P No EVA
rs465193051 148 E>A No EVA
rs447876486 151 K>N No EVA
rs432378159 151 K>R No EVA
rs436559603 155 N>Y No EVA
rs455049382 161 R>L No EVA
rs476310165 163 V>G No EVA
rs436871653 171 Q>H No EVA
rs452275653 176 S>R No EVA
rs470560931 186 L>P No EVA
rs474931661 190 R>M No EVA
rs441765002 194 E>* No EVA

No associated diseases with A6QPH1

1 regional properties for A6QPH1

Type Name Position InterPro Accession
domain WIBG, Mago-binding 11 - 37 IPR015362

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus, nucleolus
  • Nucleus, nucleoplasm
  • Shuttles between the nucleus and the cytoplasm
  • Nuclear export is mediated by XPO1/CRM1
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cell junction A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
exon-exon junction complex A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

2 GO annotations of molecular function

Name Definition
ribosome binding Binding to a ribosome.
RNA binding Binding to an RNA molecule or a portion thereof.

3 GO annotations of biological process

Name Definition
exon-exon junction complex disassembly The disaggregation of an exon-exon junction complex into its constituent components.
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
positive regulation of translation Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9BRP8 PYM1 Partner of Y14 and mago Homo sapiens (Human) PR
Q8CHP5 Pym1 Partner of Y14 and mago Mus musculus (Mouse) PR
Q6PH11 pym1 Partner of Y14 and mago Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MATPYVTDET GGKYIASTQR PDGTWRKQRR VKEGYVPQEE VPVYENKYVK FFKSKPELPP
70 80 90 100 110 120
GLSPEATAPI TASRPEGGEP ALSKTAKRNL KRKEKRRQQQ EKGEAEALSR TLEKVSLGET
130 140 150 160 170 180
AQVPSAPQAS RAAPTAASDQ PDSAATTEKA KKIKNLKKKL RQVEELQQRI QAGEISQPSK
190 200
EQLEKLARRR ALEEELEDLE LGL