Q8CHI9

PR
Gene name
Chst15 (Galnac4s6st)
Protein name
Carbohydrate sulfotransferase 15
Names
N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase, GalNAc4S-6ST
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:286974
EC number
2.8.2.33: Sulfotransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-64 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8CHI9

Entry ID Method Resolution Chain Position Source
AF-Q8CHI9-F1 Predicted AlphaFoldDB

No variants for Q8CHI9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8CHI9

No associated diseases with Q8CHI9

No regional properties for Q8CHI9

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8CHI9

Functions

Description
EC Number 2.8.2.33 Sulfotransferases
Subcellular Localization
  • Golgi apparatus membrane ; Single-pass type II membrane protein
  • A small fraction may also be present at the cell surface, where it acts as a B-cell receptor
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
3'-phosphoadenosine 5'-phosphosulfate binding Binding to 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems.
N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity Catalysis of the reactions: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate and 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate.

1 GO annotations of biological process

Name Definition
hexose biosynthetic process The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q7LFX5 CHST15 Carbohydrate sulfotransferase 15 Homo sapiens (Human) PR
Q91XQ5 Chst15 Carbohydrate sulfotransferase 15 Mus musculus (Mouse) PR
10 20 30 40 50 60
MRHCINCCIQ LFPEDAHKQQ VACQGGPHHS HQACPSCKGE DKILFRVDSK QMNLLAVLEV
70 80 90 100 110 120
RTEGNENWGG FLRFRKGKRC SLVFGLIIMT LVMASYILSG AHQELLISSP FHYGGFPSNP
130 140 150 160 170 180
SVMDSESPSD VKEHHYQPSV NNISYVKDYP NIKLIIDSIA ARNEFTTRQL PDLQDLKRQE
190 200 210 220 230 240
LHMFSVIPNK FLPTSKSPCW YEEFSGRNTT DPYLTNSYVL YSKRFRSTFD TLRKAFWGHL
250 260 270 280 290 300
SHVHGKHFRL RCLPHFYIIG QPKCGTTDLY DRLRLHPEVK FSAIKEPHWW TRKRFGIVRL
310 320 330 340 350 360
RDGLRDRYPV EDYLDLFDLA AHQIHQGLQA ASAEQTSKMN RIIIGEASAS TMWDNNAWTF
370 380 390 400 410 420
FYDNSTDGEP PFLTQDFIHA FQPEAKLLVM LRDPVERLYS DYLYFASSNK SADDFHEKVT
430 440 450 460 470 480
EALQLFENCM LDYSLRACVY NNTLNNAMPV RLQVGLYAVY LLDWLTVFSK EQFLILRLED
490 500 510 520 530 540
HASNVKYTMH KVFQFLNLGP LSEKQEALMT KSPASNTRRP EDRSLGPMWP ITQKILRDFY
550 560
GPFNTRLAQV LDDEAFAWKT T