AiPD: Autoinhibited Protein Database

Q7LFX5

Gene name	CHST15 (BRAG, GALNAC4S6ST, KIAA0598)
Protein name	Carbohydrate sulfotransferase 15
Names	B-cell RAG-associated gene protein, hBRAG, N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase, GalNAc4S-6ST
Species	Homo sapiens (Human)
KEGG Pathway	hsa:51363
EC number	2.8.2.33: Sulfotransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-59 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-59 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q7LFX5

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q7LFX5-F1	Predicted				AlphaFoldDB

469 variants for Q7LFX5

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs770564232 CA5733254	4	C>*		No	ClinGen ExAC TOPMed gnomAD
rs1366205901 CA378632089	9	I>M		No	ClinGen TOPMed gnomAD
CA215210102 rs778153454	9	I>T		No	ClinGen Ensembl
rs1249449178 CA378632040	12	L>*		No	ClinGen gnomAD
rs1469448537 CA378632010	13	P>R		No	ClinGen gnomAD
CA5733253 rs746735036	13	P>T		No	ClinGen ExAC gnomAD
CA5733250 rs200819458	14	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA
rs375999783 CA5733248	15	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
RCV000947298 CA5733246 rs35043821	16	A>T		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA378631939 rs1256306513	17	H>P		No	ClinGen TOPMed
rs1302290887 CA378631928	17	H>Q		No	ClinGen TOPMed gnomAD
rs781491426 CA5733244	18	K>M		No	ClinGen ExAC gnomAD
rs750501776 CA5733245	18	K>Q		No	ClinGen ExAC gnomAD
CA378631859 rs1590264318	20	Q>L		No	ClinGen Ensembl
CA378631811 rs1590264304	22	N>S		No	ClinGen Ensembl
rs1435814204 CA378631778	23	C>*		No	ClinGen gnomAD
rs757493998 CA5733242	24	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs751807976 CA5733241	25	G>E		No	ClinGen ExAC TOPMed gnomAD
CA5733240 rs764322427	26	G>A		No	ClinGen ExAC gnomAD
rs1451412208 CA378631724	26	G>C		No	ClinGen TOPMed gnomAD
CA378631704 rs902433319	27	P>L		No	ClinGen TOPMed gnomAD
rs902433319 CA215210035	27	P>R		No	ClinGen TOPMed gnomAD
rs763394162 CA5733239	28	H>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	28	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA215210018 rs755059839	30	G>A		No	ClinGen TOPMed gnomAD
CA378631626 rs150299035	30	G>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA378631622 rs755059839	30	G>D		No	ClinGen TOPMed gnomAD
CA378631630 rs150299035	30	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA5733237 rs150299035	30	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA215210013 rs140144074	31	H>Y		No	ClinGen ESP TOPMed gnomAD
rs776107373 CA5733235	32	Q>H		No	ClinGen ExAC gnomAD
rs34639461 CA378631544	33	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA378631555 rs1256939044	33	A>P		No	ClinGen TOPMed gnomAD
rs1256939044 CA378631554	33	A>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs34639461 CA5733234	33	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA378631514 rs1302897290	34	C>*		No	ClinGen gnomAD
CA378631534 rs1347149299	34	C>S		No	ClinGen TOPMed
rs550796211 CA5733232	36	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	42	K>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA378631346 rs1253119715	42	K>N		No	ClinGen TOPMed
rs1228184007 CA378631361	42	K>Q		No	ClinGen TOPMed
rs772770065 CA215210000	42	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs199943528 CA5733227	45	F>L		No	ClinGen ExAC TOPMed gnomAD
rs201537622 CA5733226 COSM1346568	46	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA5733225 rs201960331	46	R>H	Variant assessed as Somatic; 0.0005081 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA378631289 rs201960331	46	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA378631285 COSM1346566 rs1374287131	47	V>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA5733223 rs778034096	49	S>G		No	ClinGen ExAC TOPMed gnomAD
CA378631252 rs1257390586	49	S>R		No	ClinGen TOPMed gnomAD
rs201571991 CA215209965	52	M>K		No	ClinGen Ensembl
CA5733222 rs758588551	53	N>I		No	ClinGen ExAC
rs753052819 CA5733221	58	L>F		No	ClinGen ExAC gnomAD
rs140903668 COSM3414787 CA5733219	59	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA378631168 rs1462086920	62	T>A		No	ClinGen gnomAD
rs754349422 CA5733218	64	G>E		No	ClinGen ExAC TOPMed gnomAD
CA5733215 rs199887555 COSM1703212	66	E>K	Variant assessed as Somatic; impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1397847548 CA378631135	67	N>H		No	ClinGen TOPMed
TCGA novel	68	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA215209944 rs990504779	68	W>R		No	ClinGen Ensembl
rs1297530656 CA378631118	69	G>R		No	ClinGen TOPMed
CA5733214 rs145631200	73	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM203240 CA5733212 rs750731230	73	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA5733213 rs750731230	73	R>L		No	ClinGen ExAC TOPMed gnomAD
CA215209940 rs1000489006	75	K>E		No	ClinGen Ensembl
CA5733210 rs199919262	75	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1245524418 CA378631068	76	K>N		No	ClinGen TOPMed
CA378631062 rs1292697537	77	G>E		No	ClinGen TOPMed
TCGA novel	78	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5733209 rs775587426	78	K>N		No	ClinGen ExAC gnomAD
rs1165652161 CA378631053	79	R>*	Variant assessed as Somatic; 4.619e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA5733208 rs376384195 COSM1201163	79	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA378631049 rs1419275895	80	C>R		No	ClinGen gnomAD
CA5733206 rs148589652	83	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs758631336 CA5733205	84	F>Y		No	ClinGen ExAC gnomAD
rs1004179959 CA215209920	87	I>T		No	ClinGen TOPMed
CA378630977 rs1564883742	90	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA378630973 rs1195324491	91	L>S		No	ClinGen gnomAD
rs779184509 CA5733203	93	M>T		No	ClinGen ExAC TOPMed gnomAD
rs1273780099 CA378630952	94	A>D		No	ClinGen gnomAD
CA5733202 rs755366948	95	S>F		No	ClinGen ExAC gnomAD
rs754294487 CA5733201	96	Y>D		No	ClinGen ExAC gnomAD
CA5733200 rs766890571	96	Y>F		No	ClinGen ExAC gnomAD
rs1337191771 CA378630920	99	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA378630910 rs1390360770	101	A>D		No	ClinGen gnomAD
CA378630909 rs1390360770	101	A>G		No	ClinGen gnomAD
rs766997151 CA5733197	103	Q>E		No	ClinGen ExAC gnomAD
rs1460353200 CA378630896	103	Q>R		No	ClinGen gnomAD
rs774176086 CA5733194	105	L>P		No	ClinGen ExAC gnomAD
rs762816153 CA5733192	106	L>Q		No	ClinGen ExAC gnomAD
rs559602000 CA5733191	107	I>F		No	ClinGen 1000Genomes ExAC gnomAD
rs1211830928 CA378630864	108	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA215209875 rs372136608	110	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA5733189 rs372136608	110	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA5733188 rs773283280	112	H>D		No	ClinGen ExAC gnomAD
TCGA novel	112	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM268377 CA5733186 rs748331919	114	G>R	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA378630823 rs1237865299	115	G>S		No	ClinGen gnomAD
rs1327340110 CA378630816	116	F>Y		No	ClinGen gnomAD
rs755244050 CA5733184	117	P>R		No	ClinGen ExAC gnomAD
CA378630804 rs1394426718	118	S>C		No	ClinGen gnomAD
CA378630805 rs1394426718	118	S>G		No	ClinGen gnomAD
CA378630806 rs1394426718	118	S>R		No	ClinGen gnomAD
rs1402847721 CA378630788	120	P>S		No	ClinGen gnomAD
rs555659421 CA215209802	123	M>I		No	ClinGen 1000Genomes
CA215209804 rs1048466995	123	M>V		No	ClinGen TOPMed
CA5733180 rs750910183	126	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs767010892 CA5733179	127	N>K		No	ClinGen ExAC TOPMed gnomAD
rs796892739 CA215209797	127	N>S		No	ClinGen Ensembl
rs796892739 CA378630736	127	N>T		No	ClinGen Ensembl
CA215209787 rs76041766	131	T>K		No	ClinGen Ensembl
CA5733178 rs756847428	133	E>G		No	ClinGen ExAC gnomAD
CA215209784 rs756847428	133	E>V		No	ClinGen ExAC gnomAD
CA5733177 rs751160286	134	H>R		No	ClinGen ExAC TOPMed gnomAD
CA378630671 rs1304789188	136	H>L		No	ClinGen gnomAD
rs1284085908 CA378630676	136	H>Y		No	ClinGen TOPMed
rs762760114 CA5733175	137	Q>E		No	ClinGen ExAC gnomAD
TCGA novel	146	M>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1218567186 CA378630606	146	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs759452827 CA5733172	148	D>Y		No	ClinGen ExAC gnomAD
rs759074044 CA215209766	150	P>S		No	ClinGen gnomAD
rs79932850 CA5733171	153	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs761859751 CA5733168	157	N>D		No	ClinGen ExAC gnomAD
CA378630518 rs1377521114	157	N>S		No	ClinGen TOPMed gnomAD
rs1391561473 CA378630501	158	S>N		No	ClinGen TOPMed gnomAD
rs1391561473 CA378630503	158	S>T		No	ClinGen TOPMed gnomAD
rs1166105472 CA378630471	160	T>R		No	ClinGen gnomAD
rs201859330 CA5733166	161	T>A		No	ClinGen 1000Genomes ExAC gnomAD
rs776714793 CA5733165	164	E>K		No	ClinGen ExAC TOPMed gnomAD
rs368465329 CA5733164	166	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs565409809 CA5733162	167	T>S		No	ClinGen 1000Genomes ExAC gnomAD
CA5733160 rs781525292	169	Q>E		No	ClinGen ExAC gnomAD
rs777481863 CA215209683	175	D>E		No	ClinGen ExAC TOPMed gnomAD
rs146087527 CA5733158	175	D>Y		No	ClinGen ESP ExAC TOPMed
CA5733156 rs758066803	176	L>P		No	ClinGen ExAC gnomAD
CA215209668 rs991623597	177	K>E		No	ClinGen Ensembl
CA378630221 rs1273110657	178	K>N		No	ClinGen gnomAD
rs1171927503 CA378630215	179	Q>E		No	ClinGen gnomAD
rs1291830853 CA378629960	189	N>S		No	ClinGen TOPMed gnomAD
rs142884957 CA5733136	195	S>C		No	ClinGen ESP ExAC gnomAD
CA5733135 rs778409986	197	S>N		No	ClinGen ExAC gnomAD
rs754701134 CA5733134	198	P>S		No	ClinGen ExAC gnomAD
CA378629882 rs1281871369	200	W>*		No	ClinGen TOPMed
rs1419854730 CA378629877	200	W>*		No	ClinGen gnomAD
CA378629884 rs1461906111	200	W>R		No	ClinGen gnomAD
CA378629872 rs1162563351	201	Y>C		No	ClinGen gnomAD
rs755992309 COSM1703210 CA5733131	202	E>K	skin [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA5733128 rs144796173	203	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5733130 rs750368427	203	E>K		No	ClinGen ExAC gnomAD
rs765371014 COSM396660 CA5733126	205	S>L	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA5733127 rs775676762	205	S>P		No	ClinGen ExAC gnomAD
CA5733123 rs113034115	206	G>A		No	ClinGen ExAC TOPMed gnomAD
CA5733122 rs113034115	206	G>E		No	ClinGen ExAC TOPMed gnomAD
rs772684168 CA5733120	207	Q>E		No	ClinGen ExAC gnomAD
CA5733119 rs747582261	207	Q>L		No	ClinGen ExAC gnomAD
CA215209177 rs1014795251	208	N>K		No	ClinGen TOPMed
CA5733118 rs778553481	208	N>T		No	ClinGen ExAC TOPMed gnomAD
rs1590257270 CA378629822	209	T>I		No	ClinGen Ensembl
TCGA novel	211	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA378629815 rs748985634	211	D>H		No	ClinGen ExAC TOPMed gnomAD
COSM915798 rs748985634 CA5733116	211	D>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs748985634 CA5733117	211	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs750264072 CA5733113	212	P>L		No	ClinGen ExAC gnomAD
rs755937325 CA5733114	212	P>S		No	ClinGen ExAC gnomAD
rs1355498643 CA378629800	213	Y>F		No	ClinGen TOPMed
rs1457250009 CA378629804	213	Y>H		No	ClinGen gnomAD
CA378629795 rs1345556956	214	L>F		No	ClinGen gnomAD
CA378629793 rs1160951738	214	L>P		No	ClinGen gnomAD
CA215209161 rs913645132	215	T>I		No	ClinGen Ensembl
CA215209158 rs986607169	217	S>A		No	ClinGen TOPMed
CA378629774 rs1455177427	217	S>C		No	ClinGen gnomAD
rs1455177427 CA378629775	217	S>Y		No	ClinGen gnomAD
CA5733107 rs199953738	219	V>A		No	ClinGen ExAC TOPMed gnomAD
CA378629764 CA378629765 rs765371622	219	V>L		No	ClinGen ExAC TOPMed gnomAD
rs765371622 CA5733108	219	V>M		No	ClinGen ExAC TOPMed gnomAD
CA5733105 rs766799219	220	L>F		No	ClinGen ExAC gnomAD
rs975312065 CA378629751	221	Y>*		No	ClinGen TOPMed gnomAD
CA5733104 rs761098893	221	Y>S		No	ClinGen ExAC gnomAD
CA378629744 rs1299186980	222	S>F		No	ClinGen gnomAD
rs1368830614 CA378629748	222	S>P		No	ClinGen gnomAD
CA5733103 rs773753799	223	K>E		No	ClinGen ExAC gnomAD
rs532810140 CA5733102	223	K>N		No	ClinGen ExAC TOPMed gnomAD
CA378629740 rs1362493735	223	K>R		No	ClinGen gnomAD
rs1451301579 CA378629731	224	R>G		No	ClinGen gnomAD
rs748750523 CA5733101	224	R>H		No	ClinGen ExAC TOPMed gnomAD
rs748750523 CA378629728	224	R>P		No	ClinGen ExAC TOPMed gnomAD
rs768221458 CA5733099	225	F>C		No	ClinGen ExAC gnomAD
CA5733098 rs748902428 COSM1346560	226	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs748902428 CA378629699	226	R>L		No	ClinGen ExAC TOPMed gnomAD
CA378629703 rs1590256639	226	R>S		No	ClinGen Ensembl
rs779654815 CA5733097	227	S>C		No	ClinGen ExAC TOPMed gnomAD
rs1264425873 CA378629684	228	T>A		No	ClinGen TOPMed gnomAD
CA378629678 rs1162124439	228	T>S		No	ClinGen TOPMed
CA5733091 rs34389704	230	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs757082910 CA5733093	230	D>G		No	ClinGen ExAC
CA378629643 rs781020400	230	D>N		No	ClinGen ExAC gnomAD
CA5733094 rs781020400	230	D>Y		No	ClinGen ExAC gnomAD
rs755106803 CA5733090	231	A>P		No	ClinGen ExAC gnomAD
CA378629610 rs755106803	231	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	233	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA378629569 COSM203238 rs1228198265	233	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA5733087 rs143626003	234	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs547957889 CA5733086	234	K>R		No	ClinGen 1000Genomes ExAC gnomAD
rs28544089 CA215209091	235	A>G		No	ClinGen gnomAD
rs1053007460 CA215209095	235	A>T		No	ClinGen TOPMed gnomAD
rs28544089 CA378629510	235	A>V		No	ClinGen gnomAD
CA378629498 rs1313178158	236	F>V		No	ClinGen gnomAD
rs1399527278 CA378629462	237	W>C		No	ClinGen gnomAD
CA5733085 rs767941511	238	G>S		No	ClinGen ExAC TOPMed gnomAD
CA5733084 rs762163102	239	H>Y		No	ClinGen ExAC gnomAD
rs1243304457 CA378629415	240	L>P		No	ClinGen TOPMed
rs373338090 CA5733083	240	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs762415904 CA378629399	241	A>E		No	ClinGen ExAC TOPMed gnomAD
CA5733081 rs762415904	241	A>V		No	ClinGen ExAC TOPMed gnomAD
rs931640046 CA215209071	242	H>D		No	ClinGen TOPMed
TCGA novel	242	H>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA215209066 rs781451777	243	A>T		No	ClinGen TOPMed
rs561766757 CA5733080	243	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs186851094 CA5733078	244	H>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5733077 rs780782529	245	G>E		No	ClinGen ExAC gnomAD
CA378629330 rs878912191 CA215209059	245	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA5733075 rs746872838	247	H>D		No	ClinGen ExAC TOPMed gnomAD
rs1590255946 CA378629286	247	H>P		No	ClinGen Ensembl
rs746872838 CA215209044	247	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs531511922 CA5733074	248	F>V		No	ClinGen 1000Genomes ExAC gnomAD
CA215209027 rs866135394	249	R>L		No	ClinGen Ensembl
rs373115407 CA5733073	250	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs373115407 CA215209017	250	L>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA378629222 rs1234859628	251	R>G		No	ClinGen gnomAD
rs1338359559 CA378629215	251	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA378629214 rs1338359559	251	R>P		No	ClinGen TOPMed gnomAD
CA215209006 rs907644359	254	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs780340462 CA5733071	254	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA378629159 rs1419166387	255	H>R		No	ClinGen TOPMed gnomAD
CA378629163 rs1328905238	255	H>Y		No	ClinGen TOPMed gnomAD
CA378629136 rs1472004157	257	Y>H		No	ClinGen gnomAD
rs750681384 CA5733068	258	I>M		No	ClinGen ExAC TOPMed gnomAD
CA5733067 rs757620385	259	I>L		No	ClinGen ExAC TOPMed gnomAD
rs757620385 CA215208990	259	I>V		No	ClinGen ExAC TOPMed gnomAD
CA378629091 rs1335602954	261	Q>K		No	ClinGen TOPMed
CA215208986 rs564365421	261	Q>L		No	ClinGen 1000Genomes
rs1248529306 CA378629055	263	K>R		No	ClinGen gnomAD
CA378629043 rs1383291142	264	C>G		No	ClinGen TOPMed
CA378629014 rs1246670334	266	T>S		No	ClinGen TOPMed
rs946205492 CA215208984	267	T>R		No	ClinGen Ensembl
rs79202356 CA215208967	268	D>A		No	ClinGen Ensembl
CA215208981 rs1027982256	268	D>N		No	ClinGen TOPMed
TCGA novel	270	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5733064 rs545770018	273	L>M		No	ClinGen 1000Genomes ExAC gnomAD
rs1283302395 CA378628917	273	L>Q		No	ClinGen gnomAD
rs774921257 CA5733062	274	R>Q		No	ClinGen ExAC gnomAD
TCGA novel	274	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769296290 CA5733061	275	L>R		No	ClinGen ExAC TOPMed gnomAD
CA378628893 rs1590255213	276	H>D		No	ClinGen Ensembl
CA378628874 rs1306457046	277	P>S		No	ClinGen gnomAD
CA5733058 rs770538087	278	E>*		No	ClinGen ExAC gnomAD
COSM1248313 CA215208934 CA5733056 rs146440479	278	E>D	oesophagus [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA378628868 rs770538087	278	E>K		No	ClinGen ExAC gnomAD
rs746788285 CA5733057	278	E>V		No	ClinGen ExAC gnomAD
CA378628847 rs1590255097	279	V>G		No	ClinGen Ensembl
CA378628838 rs1390451168	280	K>R		No	ClinGen TOPMed gnomAD
CA378628807 rs1159450831	282	S>F		No	ClinGen gnomAD
CA5733054 rs780219214	283	A>S		No	ClinGen ExAC gnomAD
rs780219214 CA5733053	283	A>T		No	ClinGen ExAC gnomAD
CA378628795 rs1362406894	284	I>V		No	ClinGen TOPMed
TCGA novel	286	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5733052 rs527282589	288	H>Q		No	ClinGen ExAC gnomAD
rs145847740 CA5733050	292	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs559698999 CA5733049	294	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs375906303 CA5733030	298	V>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs757439959 CA5733031	298	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs544235718 CA5733029	299	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA5733028 rs758783490	302	D>G		No	ClinGen ExAC gnomAD
CA378628461 rs1291394659	304	L>Q		No	ClinGen TOPMed
CA5733027 rs753109595	305	R>Q		No	ClinGen ExAC gnomAD
CA5733026 rs765702333	307	R>C		No	ClinGen ExAC gnomAD
CA378628443 COSM2021145 rs1415637713	307	R>H	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA5733024 rs201649749	308	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
rs201649749 CA378628439 COSM3790568	308	Y>S	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
CA5733023 rs765822393	309	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA378628429 CA5733021 COSM1188077 rs772773156	310	V>L	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs772773156 CA378628430	310	V>M	Variant assessed as Somatic; 9.241e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA215207776 rs1027619664	316	L>F		No	ClinGen Ensembl
rs368746217 CA5733018	321	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs368746217 CA5733017	321	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs376959811 CA5733016	321	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA5733014 rs200528082	322	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5733015 rs776703334	322	H>R		No	ClinGen ExAC TOPMed gnomAD
CA215207732 rs369626951	323	Q>E		No	ClinGen ESP gnomAD
TCGA novel	324	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA378628330 rs1194657869	325	H>Y		No	ClinGen TOPMed
CA378628297 rs1186421250	329	Q>*		No	ClinGen TOPMed
rs1025570012 CA215207720	329	Q>R		No	ClinGen TOPMed gnomAD
rs897867340 CA215207713	334	K>Q		No	ClinGen TOPMed gnomAD
rs1234237582 CA378628237	334	K>R		No	ClinGen gnomAD
CA5733011 rs772319898	338	K>E		No	ClinGen ExAC gnomAD
rs1393291788 CA378628156	339	M>T		No	ClinGen TOPMed
rs1311546649 CA378628130	340	N>K		No	ClinGen gnomAD
CA5733010 rs748507698	340	N>S		No	ClinGen ExAC gnomAD
rs1461638120 CA378628117	342	I>V		No	ClinGen TOPMed
CA378628072 rs1386161063	345	G>R		No	ClinGen TOPMed
rs370575368 CA5732981	349	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs199646326 CA215253782	350	S>F		No	ClinGen Ensembl
CA5732980 rs762632664	350	S>P		No	ClinGen ExAC gnomAD
CA215253792 rs199646326	350	S>Y		No	ClinGen Ensembl
CA5732979 rs139382761	351	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA5732978 rs765080969	352	M>R		No	ClinGen ExAC gnomAD
rs1376244891 CA378637909 COSM79344	353	W>*	ovary [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1475262801 CA378637901	354	D>V		No	ClinGen TOPMed
rs759527488 CA5732977	356	N>S		No	ClinGen ExAC gnomAD
rs376794217 CA5732976	357	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs767590394 CA378637866	359	T>K		No	ClinGen ExAC TOPMed gnomAD
rs767590394 COSM1346556 CA5732975	359	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1457173671 CA378637860	360	F>S		No	ClinGen gnomAD
CA378637853 rs1365858614	361	F>Y		No	ClinGen TOPMed
rs1160083771 CA378637844	362	Y>C		No	ClinGen gnomAD
rs1345465697 CA378637848	362	Y>N		No	ClinGen gnomAD
CA215253709 rs1040064513	363	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA215253684 rs375061085	365	S>G		No	ClinGen ESP TOPMed gnomAD
rs78587239 CA5732971	366	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA378637806 rs1265696690	367	D>E		No	ClinGen gnomAD
CA378637811 rs1486381652	367	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA5732969 rs370938065	368	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs377751476 CA5732967	369	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA5732966 rs756861563	370	P>L		No	ClinGen ExAC gnomAD
CA5732964 rs374459985	371	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	373	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752430304 CA5732962	374	T>A		No	ClinGen ExAC gnomAD
rs765085481 CA5732961	374	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1162416558 CA378637764	375	Q>*		No	ClinGen TOPMed
rs1339915609 CA378637733	379	H>Y		No	ClinGen gnomAD
CA378637724 rs1383715827	380	A>G		No	ClinGen TOPMed
rs767543459 CA5732958 COSM3686563	380	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA378637725 rs1383715827	380	A>V		No	ClinGen TOPMed
CA378637717 rs1376477538	381	F>C		No	ClinGen TOPMed gnomAD
rs1376477538 CA378637718	381	F>S		No	ClinGen TOPMed gnomAD
CA378637704 rs1175975127	383	P>S		No	ClinGen gnomAD
CA378637695 rs1429539478	384	N>I		No	ClinGen gnomAD
CA378637683 rs1426247014	386	R>K		No	ClinGen gnomAD
rs1202298123 CA378637664	389	V>A		No	ClinGen TOPMed gnomAD
CA215253609 rs968844331	389	V>I		No	ClinGen TOPMed gnomAD
rs1020481808 CA215253608	390	M>T		No	ClinGen Ensembl
rs1482298801 CA378637648	392	R>G		No	ClinGen gnomAD
rs1363531412 CA378635530	398	L>S		No	ClinGen TOPMed
rs1230939319 CA378635473	402	Y>C		No	ClinGen TOPMed
rs753671778 CA5732941	402	Y>H		No	ClinGen ExAC gnomAD
CA215237623 rs953013162	403	L>P		No	ClinGen Ensembl
CA378635429 rs1338264919	404	Y>*		No	ClinGen gnomAD
CA5732939 rs756098645	407	S>N		No	ClinGen ExAC gnomAD
rs375217023 CA378635371	408	S>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs375217023 COSM1201155 CA5732938	408	S>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs372003076 CA5732935	412	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA5732934 rs201369174	412	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1417205522 CA378635253	414	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs894832281 CA215237566	416	H>R		No	ClinGen TOPMed
rs771561093 CA5732931	418	K>N		No	ClinGen ExAC gnomAD
rs761249169 CA5732930	419	V>A		No	ClinGen ExAC gnomAD
rs772538245 CA5732929	421	E>A		No	ClinGen ExAC TOPMed gnomAD
rs772538245 CA378635109	421	E>V		No	ClinGen ExAC TOPMed gnomAD
CA215237545 rs533841906	422	A>V		No	ClinGen 1000Genomes
TCGA novel	423	L>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA378635078 rs1176689505	423	L>P		No	ClinGen gnomAD
rs771634024 CA5732928	424	Q>L		No	ClinGen ExAC TOPMed gnomAD
rs771634024 CA378635065	424	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs778594589 CA5732927	430	M>L		No	ClinGen ExAC TOPMed gnomAD
rs778594589 CA5732926	430	M>V		No	ClinGen ExAC TOPMed gnomAD
CA378634959 rs1347475019	432	D>Y		No	ClinGen TOPMed
CA378634915 rs1211367226	436	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA5732925 rs768345051	436	R>H		No	ClinGen ExAC TOPMed gnomAD
rs779887614 CA378634909	437	A>S		No	ClinGen ExAC TOPMed gnomAD
CA5732923 rs779887614	437	A>T		No	ClinGen ExAC TOPMed gnomAD
rs755974129 CA5732922	437	A>V		No	ClinGen ExAC TOPMed gnomAD
rs758477205 CA5732919	439	V>A		No	ClinGen ExAC gnomAD
rs777679104 CA378634890	439	V>F		No	ClinGen ExAC TOPMed gnomAD
COSM290154 CA5732920 rs777679104	439	V>I	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA378634877 rs1256963586	440	Y>F		No	ClinGen TOPMed
CA378634852 rs1325972148	442	N>T		No	ClinGen gnomAD
CA5732917 rs765544646	443	T>P		No	ClinGen ExAC
rs759906459 CA5732916	444	L>F		No	ClinGen ExAC gnomAD
rs1378565331 CA378634808	446	N>S		No	ClinGen gnomAD
rs1564854419 CA378634800	447	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA378634779 rs1469589861	448	M>I		No	ClinGen gnomAD
CA5732807 rs746058250	453	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs201467916 CA5732806	454	V>I		No	ClinGen 1000Genomes ExAC gnomAD
CA215229068 rs866055825	456	L>F		No	ClinGen Ensembl
CA5732805 rs555247313	458	A>S		No	ClinGen 1000Genomes ExAC gnomAD
CA5732804 rs747372836	460	Y>F		No	ClinGen ExAC gnomAD
rs1026818568 CA215229065	462	L>R		No	ClinGen TOPMed gnomAD
CA5732801 COSM1346548 rs200319997	467	V>I	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1417387316 CA378632815	469	D>E		No	ClinGen TOPMed
rs1590172242 CA378632798	472	Q>K		No	ClinGen Ensembl
CA378632774 rs1564846756	475	I>F		No	ClinGen Ensembl
rs1237995287 CA378632767	476	L>F		No	ClinGen gnomAD
COSM203233 rs753436566 CA215229009	477	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA5732798 rs753436566	477	R>G		No	ClinGen ExAC TOPMed gnomAD
CA5732797 rs367705392	477	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA215229006 rs367705392	477	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA378632739 rs1422096064	481	H>D		No	ClinGen TOPMed
CA378632721 rs1219654062	483	S>F		No	ClinGen gnomAD
CA5732795 rs576695868	484	N>S		No	ClinGen ExAC TOPMed gnomAD
rs576695868 CA5732796	484	N>T		No	ClinGen ExAC TOPMed gnomAD
CA378632714 rs1403959315	485	V>I		No	ClinGen gnomAD
rs761789617 CA5732793	488	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1299520036 CA378632690	488	T>S		No	ClinGen gnomAD
rs1448217502 CA378632683	489	M>T		No	ClinGen TOPMed
TCGA novel	490	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs61751898 CA215228927	491	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs774183284 CA5732792	491	K>R		No	ClinGen ExAC gnomAD
CA5732789 rs776840518	493	F>L		No	ClinGen ExAC TOPMed gnomAD
CA5732788 COSM1726954 rs145783909	497	N>Y	liver [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA5732787 rs747247902	498	L>V		No	ClinGen ExAC gnomAD
CA378632370 rs1590167828	499	G>A		No	ClinGen Ensembl
rs1378964133 CA378632619	499	G>R		No	ClinGen TOPMed
CA215227225 rs34096710	500	P>A		No	ClinGen gnomAD
CA378632368 rs34096710	500	P>T		No	ClinGen gnomAD
CA5732762 rs779659372	501	L>F		No	ClinGen ExAC gnomAD
rs755713145 CA5732761	502	S>N		No	ClinGen ExAC TOPMed gnomAD
rs1204433309 CA378632342	502	S>R		No	ClinGen TOPMed
CA215227203 rs779199392	505	Q>R		No	ClinGen Ensembl
rs745407524 CA5732760	507	A>T		No	ClinGen ExAC gnomAD
CA215227185 rs958149660	511	K>E		No	ClinGen Ensembl
rs1294695378 CA378632202	511	K>R		No	ClinGen Ensembl
rs1182927775 CA378632170	513	P>S		No	ClinGen TOPMed gnomAD
COSM1346547 rs202236206 CA5732757	514	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1193812035 CA378632157	514	A>V		No	ClinGen gnomAD
rs751247974 CA378632104	518	R>W		No	ClinGen ExAC TOPMed gnomAD
CA378632093 rs1246429753 COSM1248315	519	R>C	Variant assessed as Somatic; 0.0 impact. oesophagus [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA215227148 rs1031395822	520	P>L		No	ClinGen TOPMed
CA5732755 rs371109329	520	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA5732753 rs752664325	523	R>Q		No	ClinGen ExAC gnomAD
rs1448169808 CA378632023	523	R>W		No	ClinGen gnomAD
rs1178003225 CA378631977	526	G>V		No	ClinGen TOPMed
rs982427414 CA215227110	527	P>L		No	ClinGen TOPMed
CA378631931 rs1441405117	529	W>L		No	ClinGen TOPMed
rs1327278875 CA378631900	530	P>L		No	ClinGen gnomAD
CA5732751 rs765199201	530	P>S		No	ClinGen ExAC gnomAD
CA378631909 rs765199201	530	P>T		No	ClinGen ExAC gnomAD
CA5732750 rs773338113	531	I>F		No	ClinGen ExAC TOPMed gnomAD
CA5732748 rs200264048	531	I>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs773338113 CA5732749	531	I>V		No	ClinGen ExAC TOPMed gnomAD
CA378631875 rs1245663733	533	Q>*		No	ClinGen gnomAD
CA5732747 rs762098557	533	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1384694634 CA378631828	535	I>T		No	ClinGen gnomAD
rs774519865 CA5732745	537	R>G		No	ClinGen ExAC gnomAD
rs1281580042 CA378631804	537	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
COSM1346546 rs774519865 CA5732742	537	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
TCGA novel rs769084259 CA5732741	539	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen ExAC gnomAD
rs749717029 CA5732739	540	Y>C		No	ClinGen ExAC gnomAD
rs61740008 CA5732738	541	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs780855747 CA5732735	545	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA215227009 rs776567714	545	A>V		No	ClinGen Ensembl
CA5732732 rs566025595	548	A>E		No	ClinGen ExAC TOPMed gnomAD
CA5732734 rs770435977	548	A>T		No	ClinGen ExAC
rs566025595 CA5732733	548	A>V		No	ClinGen ExAC TOPMed gnomAD
rs752539430 CA5732730	550	V>I		No	ClinGen ExAC gnomAD
CA5732728 rs754974252	551	L>V		No	ClinGen ExAC TOPMed gnomAD
CA5732726 rs767648594	552	A>T		No	ClinGen ExAC gnomAD
CA5732725 rs761889134	553	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs764261201 CA5732723	554	E>A		No	ClinGen ExAC TOPMed gnomAD
CA5732724 rs201307325	554	E>K		No	ClinGen ExAC TOPMed gnomAD
CA378631536 rs764261201	554	E>V		No	ClinGen ExAC TOPMed gnomAD
CA5732722 rs763384902	555	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs148977403 CA5732719	557	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA5732718 rs377640808	557	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs570907472 CA5732716	560	T>A		No	ClinGen 1000Genomes ExAC gnomAD
rs201459284 CA5732715	560	T>M	Variant assessed as Somatic; 0.0001388 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5732714 rs771680734	561	T>A		No	ClinGen ExAC gnomAD
CA5732713 rs747931234	561	T>M		No	ClinGen ExAC
rs747931234 CA378631419	561	T>R		No	ClinGen ExAC
rs1371970993 CA378631407	562	T>G		No	ClinGen Ensembl

No associated diseases with Q7LFX5

No regional properties for Q7LFX5

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q7LFX5

Functions

		Description
EC Number	2.8.2.33	Sulfotransferases
Subcellular Localization	Golgi apparatus membrane ; Single-pass type II membrane protein	A small fraction may also be present at the cell surface, where it acts as a B-cell receptor
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name	Definition
3'-phosphoadenosine 5'-phosphosulfate binding	Binding to 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems.
N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity	Catalysis of the reactions: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate and 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate.

2 GO annotations of biological process

Name	Definition
chondroitin sulfate biosynthetic process	The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.
hexose biosynthetic process	The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q91XQ5	Chst15	Carbohydrate sulfotransferase 15	Mus musculus (Mouse)	PR
Q8CHI9	Chst15	Carbohydrate sulfotransferase 15	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MRHCINCCIQ	LLPDGAHKQQ	VNCQGGPHHG	HQACPTCKGE	NKILFRVDSK	QMNLLAVLEV
70	80	90	100	110	120
RTEGNENWGG	FLRFKKGKRC	SLVFGLIIMT	LVMASYILSG	AHQELLISSP	FHYGGFPSNP
130	140	150	160	170	180
SLMDSENPSD	TKEHHHQSSV	NNISYMKDYP	SIKLIINSIT	TRIEFTTRQL	PDLEDLKKQE
190	200	210	220	230	240
LHMFSVIPNK	FLPNSKSPCW	YEEFSGQNTT	DPYLTNSYVL	YSKRFRSTFD	ALRKAFWGHL
250	260	270	280	290	300
AHAHGKHFRL	RCLPHFYIIG	QPKCGTTDLY	DRLRLHPEVK	FSAIKEPHWW	TRKRFGIVRL
310	320	330	340	350	360
RDGLRDRYPV	EDYLDLFDLA	AHQIHQGLQA	SSAKEQSKMN	TIIIGEASAS	TMWDNNAWTF
370	380	390	400	410	420
FYDNSTDGEP	PFLTQDFIHA	FQPNARLIVM	LRDPVERLYS	DYLYFASSNK	SADDFHEKVT
430	440	450	460	470	480
EALQLFENCM	LDYSLRACVY	NNTLNNAMPV	RLQVGLYAVY	LLDWLSVFDK	QQFLILRLED
490	500	510	520	530	540
HASNVKYTMH	KVFQFLNLGP	LSEKQEALMT	KSPASNARRP	EDRNLGPMWP	ITQKILRDFY
550	560
RPFNARLAQV	LADEAFAWKT	T