Q8C7B8

PR
Gene name
Zswim4
Protein name
Zinc finger SWIM domain-containing protein 4
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:212168
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8C7B8

Entry ID Method Resolution Chain Position Source
AF-Q8C7B8-F1 Predicted AlphaFoldDB

51 variants for Q8C7B8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388996988 84 P>S No EVA
rs3388972437 112 Q>* No EVA
rs3388996704 194 Q>L No EVA
rs3389000385 239 A>E No EVA
rs3388992613 248 C>S No EVA
rs3388994090 284 R>W No EVA
rs3388994069 285 E>D No EVA
rs3388996679 285 E>V No EVA
rs3388994223 287 L>V No EVA
rs3388972421 288 R>G No EVA
rs3388992601 290 R>G No EVA
rs864304643 294 G>E No EVA
rs3388977581 341 L>M No EVA
rs229861795 347 P>S No EVA
rs32556818 379 S>N No EVA
rs3388977539 462 A>V No EVA
rs3388946847 471 A>T No EVA
rs3388999782 476 H>N No EVA
rs3388995752 511 G>S No EVA
rs3388996708 524 H>Q No EVA
rs3388994285 524 H>Y No EVA
rs3388983367 567 V>A No EVA
rs3388994308 577 A>V No EVA
rs3388990042 604 V>M No EVA
rs3388989119 605 R>C No EVA
rs3388999856 608 E>D No EVA
rs3388983331 633 L>P No EVA
rs3388976451 646 V>M No EVA
rs3388976439 690 F>Y No EVA
rs3388996970 717 L>P No EVA
rs3388992583 737 K>N No EVA
rs3388996706 740 H>Q No EVA
rs3388996980 748 Q>R No EVA
rs3388966006 752 S>F No EVA
rs3388990045 764 C>R No EVA
rs3388989084 770 A>V No EVA
rs225174729 777 V>M No EVA
rs3388996680 801 R>C No EVA
rs3398908224 850 L>* No EVA
rs3388983316 860 R>P No EVA
rs3388989971 883 A>V No EVA
rs3388992606 890 C>S No EVA
rs3388989986 899 A>P No EVA
rs3388989116 978 V>I No EVA
rs3388976418 983 R>L No EVA
rs3388990033 1039 S>C No EVA
rs3388994225 1040 H>R No EVA
rs3388966036 1045 H>Q No EVA
rs3388989987 1056 E>G No EVA
rs3388995699 1081 N>H No EVA
rs3389000390 1084 Q>* No EVA

No associated diseases with Q8C7B8

1 regional properties for Q8C7B8

Type Name Position InterPro Accession
domain Zinc finger, SWIM-type 134 - 171 IPR007527

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
Cul2-RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.

1 GO annotations of molecular function

Name Definition
zinc ion binding Binding to a zinc ion (Zn).

No GO annotations of biological process

Name Definition
No GO annotations for biological process

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9H7M6 ZSWIM4 Zinc finger SWIM domain-containing protein 4 Homo sapiens (Human) PR
Q9HCJ5 ZSWIM6 Zinc finger SWIM domain-containing protein 6 Homo sapiens (Human) PR
Q80TC6 Zswim5 Zinc finger SWIM domain-containing protein 5 Mus musculus (Mouse) PR
10 20 30 40 50 60
MEPPAAKRSR GCPAGDEPGT GARRSRPEPL LDLSAKRVAE SWAFEQVEER FSRVPEPVQK
70 80 90 100 110 120
RIVFWSFPRS EREICMYSSL GYQPPEGEQD TRVPFTRGLH LLQSGAVDRV LQVGFHLSGN
130 140 150 160 170 180
IREVGGPGEP EHLYHVSISF DRCKITSVSC GCDNRDLFYC AHVVALSLYR IRHARQVELR
190 200 210 220 230 240
LPISETLSQM NRDQLQKFVQ YLISAHHTEV LPTAQRLADE ILLLGSEINL VHGAPDPTAG
250 260 270 280 290 300
AGTEDANCWH LDEEQIQEQV KQLLSNGGHY GASQQLRSMF SKVREMLRAR DSNGARMLIL
310 320 330 340 350 360
MTEQFLQDPR LALWRQQGAG MTDKCRQLWD ELGALWVCVI LSPHCKPDER SGWLQLLGTW
370 380 390 400 410 420
DKLDVCPLEE GNYSLDIPSL QPALTSRTGS EDEEEVTAAS PRRTVFSRAL QAGELHWNDS
430 440 450 460 470 480
HLQRILASDS CGPTLTGSMG SDKPTFDPQG HPIWLGEPFP TACARVDTLR AHGYPHKALR
490 500 510 520 530 540
LACAIINTLR LQRRHQLESY KQQKKELLQK GATGVTSTEG WVGHPLDPIG CLCRALLEAC
550 560 570 580 590 600
RLEEEPHSLF PDSAPEKRKL AYQHVLVPGS PGESYLALAL EVALLGLGQQ RALPEGLYAQ
610 620 630 640 650 660
DKVVRNEEQL LALLEEVELD ERLVQVLRKQ AGLLLEGGPF SGFGEVIFRE SVPMHTCARY
670 680 690 700 710 720
LFTALLPHDP DLAFRLALRA MRLPVLETTF PAGESHPNPL DSIMSNRFPR WFILGHLETR
730 740 750 760 770 780
QCELASTMLT AAKGDTKWLH AVLGSVQQNI HSPALLFKLA QDACKTATPA SAPPDTVLLG
790 800 810 820 830 840
IALELGLQVM RMTLNTMTWR RREMVRWLVS CATEIGPPAL MSIMKNWYSL FTPVEAVTIV
850 860 870 880 890 900
AVTGTTHATL LRLQLDTAGR EELWACARTL ALQCAMKDPQ NCALPALTLC EKNHAAFEAA
910 920 930 940 950 960
YQIVLDAAAG GLGHAHLFTV ARYMEHRGLP LRAYKLATLA LAQLSIAFNQ DSHPAVNDVL
970 980 990 1000 1010 1020
WACSLSHSLG RHELSAIVPL IIRSIHCAPM LSDILRRWTL SAPGLGPLGA RRATKPLGTD
1030 1040 1050 1060 1070 1080
RAPLCQLLDA AVAAYITTSH SRLTHISPRH YGDFIEFLGK ARETFLLAPD GHLQFAQFLE
1090 1100
NLKQTYKGKK KLMLLVRERF G