Q80TC6
Gene name |
Zswim5 (Kiaa1511) |
Protein name |
Zinc finger SWIM domain-containing protein 5 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:74464 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q80TC6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q80TC6-F1 | Predicted | AlphaFoldDB |
55 variants for Q80TC6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs217514047 | 165 | G>D | No | EVA | |
| rs217514047 | 165 | G>V | No | EVA | |
| rs3388709079 | 212 | P>L | No | EVA | |
| rs3388705071 | 228 | F>S | No | EVA | |
| rs3388710566 | 233 | I>S | No | EVA | |
| rs3388709034 | 236 | V>L | No | EVA | |
| rs3412845539 | 240 | C>R | No | EVA | |
| rs3388705149 | 272 | S>L | No | EVA | |
| rs3388709082 | 317 | N>S | No | EVA | |
| rs3388699580 | 323 | P>L | No | EVA | |
| rs3388709025 | 323 | P>S | No | EVA | |
| rs3388691309 | 326 | T>I | No | EVA | |
| rs3394695544 | 414 | R>G | No | EVA | |
| rs3388703726 | 418 | D>N | No | EVA | |
| rs3388691260 | 435 | L>I | No | EVA | |
| rs3388701639 | 458 | D>G | No | EVA | |
| rs3388703796 | 462 | G>E | No | EVA | |
| rs3388696266 | 464 | E>G | No | EVA | |
| rs3388705728 | 489 | T>I | No | EVA | |
| rs3388709097 | 496 | E>A | No | EVA | |
| rs3388691319 | 521 | C>Y | No | EVA | |
| rs3388691327 | 561 | A>D | No | EVA | |
| rs3388703716 | 574 | L>F | No | EVA | |
| rs3388706834 | 575 | Q>* | No | EVA | |
| rs3388702619 | 579 | Q>R | No | EVA | |
| rs3388699211 | 580 | L>Q | No | EVA | |
| rs3388702618 | 598 | I>F | No | EVA | |
| rs3388702618 | 598 | I>V | No | EVA | |
| rs3388692393 | 688 | V>A | No | EVA | |
| rs3388706810 | 699 | L>P | No | EVA | |
| rs3388682588 | 747 | F>I | No | EVA | |
| rs3394740075 | 753 | H>VRDA* | No | EVA | |
| rs3394469543 | 775 | S>P | No | EVA | |
| rs3394469506 | 776 | S>A | No | EVA | |
| rs3394784125 | 777 | A>E | No | EVA | |
| rs3394646597 | 778 | G>D | No | EVA | |
| rs3388705738 | 791 | P>S | No | EVA | |
| rs265368428 | 828 | L>I | No | EVA | |
| rs258743592 | 839 | P>S | No | EVA | |
| rs3388699599 | 844 | K>N | No | EVA | |
| rs3388710511 | 854 | T>N | No | EVA | |
| rs248112671 | 862 | G>S | No | EVA | |
| rs3388699591 | 870 | E>G | No | EVA | |
| rs3388706870 | 879 | T>I | No | EVA | |
| rs3388699189 | 895 | V>D | No | EVA | |
| rs3388699161 | 902 | G>S | No | EVA | |
| rs3388691297 | 903 | V>M | No | EVA | |
| rs3388710550 | 927 | A>V | No | EVA | |
| rs3388703714 | 960 | C>Y | No | EVA | |
| rs3388707165 | 982 | A>T | No | EVA | |
| rs3388702614 | 1000 | H>L | No | EVA | |
| rs3388701591 | 1021 | K>N | No | EVA | |
| rs3388692324 | 1057 | K>T | No | EVA | |
| rs3394718289 | 1077 | L>H | No | EVA | |
| rs3388706884 | 1133 | I>F | No | EVA |
No associated diseases with Q80TC6
1 regional properties for Q80TC6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Zinc finger, SWIM-type | 222 - 259 | IPR007527 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| Cul2-RING ubiquitin ligase complex | A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| zinc ion binding | Binding to a zinc ion (Zn). |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9H7M6 | ZSWIM4 | Zinc finger SWIM domain-containing protein 4 | Homo sapiens (Human) | PR |
| Q9HCJ5 | ZSWIM6 | Zinc finger SWIM domain-containing protein 6 | Homo sapiens (Human) | PR |
| Q8C7B8 | Zswim4 | Zinc finger SWIM domain-containing protein 4 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAEGGEREEL | LSPPPISPAK | RLCSWPSPQA | HHPRGTPGAA | GGGAGGGGGG | CLAPGARPHL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QPESLLDCAA | KTVAEKWAYE | RVEERFERIP | EPVQRRIVYW | SFPRNEREIC | MYSSFQYRGG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PGAGAAAGAA | GASPVEEGPP | PPPGAAAPAG | SAPGAAGAGS | SPGLGAGTGT | ASGGCGGGEG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LPFRRGIRLL | DSGSVENVLQ | VGFHLSGTVT | EPAMASEPAV | TYKVAISFDR | CKITSVSCGC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GNKDIFYCAH | VVALSLYRIR | KPDQVKLRLP | ISETLFQMNR | DQLQKFIQYL | ITAHHTEVLP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TAQKLADEIL | SSNSEINQVN | GAPDPTAGAS | IDDENCWHLD | EEQVKEQVKL | FLSQGGYYGS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GKQLNSMFAK | VREMLRMRDS | NGARMLTLIT | EQFMADPRLT | LWRQQGTSMT | DKCRQLWDEL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GALWVCIILN | PHCKLEEKSC | WLQQLQKWSD | LDICPLEDGN | YGHELPNITN | ALSQSASHSP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DSLSRPRRTV | FTRAIEGREL | HWQDSHLQRI | ISSGIYTAPA | CQRENERLLF | NSHGQPLWLE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| HVPTACARVD | ALRSHGYPKE | ALRLTVAIIN | TLRLQQQRQL | EIYKHQKKEL | LQRGTTTITN |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LEGWVGHPLD | PIGCLFLTLT | EACRLNDDSY | MEMSDMNESR | LPVYQHVPVA | SGCPNSNESY |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LSLALEVALM | GMGQQRVMPE | GLYAQDKVCR | NEEQLLSQLQ | ELQLDDELVQ | TLRKQCILLL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EGGPFSGLGE | VIHRESVPMH | TFAKYLFSAL | LPHDPDLSYK | LALRAMRLPV | LENSSSAGDT |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SHPHHMVSVV | PSRYPRWFTL | GHLESQQCEL | ASTMLTAAKG | DTLRLRTLLE | AIQKHIHSPS |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LIFKLAQDAF | KIATPTDSST | DGTLLNVALE | LGLQVMRMTL | STLNWRRREM | VRWLVTCATE |
| 910 | 920 | 930 | 940 | 950 | 960 |
| VGVRALVSIL | QSWYTLFTPT | EATSIVAATA | VSHTTILRLS | LDYPQREELA | SCARTLALQC |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| AMKDPQSCAL | SALTLCEKDH | IAFEAAYQIA | IDAAAGGMTH | SQLFTIARYM | ELRGYPLRAF |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| KLASLAMSHL | NLAYNQDTHP | AINDVLWACA | LSHSLGKNEL | AALIPLVVKS | VHCATVLSDI |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| LRRCTVTAPG | LAGIPGRRSS | GKLMSTDKAP | LRQLLDATIN | AYINTTHSRL | THISPRHYGE |
| 1150 | 1160 | 1170 | 1180 | ||
| FIEFLSKARE | TFLLPQDGHL | QFAQFIDNLK | QIYKGKKKLM | LLVRERFG |