Q8C779

PR
Gene name
Radx
Protein name
RPA-related protein RADX
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:102871
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-66 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8C779

Entry ID Method Resolution Chain Position Source
AF-Q8C779-F1 Predicted AlphaFoldDB

35 variants for Q8C779

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3412287365 67 V>L No EVA
rs3412184787 105 Q>L No EVA
rs3412052012 157 E>G No EVA
rs3389543140 183 G>E No EVA
rs3409412635 203 K>M No EVA
rs3412369949 255 K>N No EVA
rs3389556107 288 K>E No EVA
rs3412052361 297 L>* No EVA
rs3410678233 305 K>Q No EVA
rs3410678304 396 S>N No EVA
rs3389526230 460 T>N No EVA
rs3412369999 480 D>N No EVA
rs3412284767 503 I>T No EVA
rs3412288816 506 Y>* No EVA
rs3411719112 507 Y>N No EVA
rs3409412620 512 V>M No EVA
rs3412185804 533 S>G No EVA
rs3389580489 543 Q>E No EVA
rs3389569382 546 E>G No EVA
rs250766942 566 H>Q No EVA
rs1134122092 582 R>H No EVA
rs3389585308 595 C>* No EVA
rs223012567 618 S>P No EVA
rs3389585300 633 P>L No EVA
rs3412371558 662 S>P No EVA
rs29258376 684 Q>R No EVA
rs215871185 685 D>A No EVA
rs3389526247 695 H>Y No EVA
rs257762844 712 H>Y No EVA
rs3389580537 786 C>Y No EVA
rs3389585262 790 S>N No EVA
rs3389585276 792 V>M No EVA
rs3389576974 796 A>G No EVA
rs3412094916 830 D>N No EVA
rs3389586673 846 I>V No EVA

No associated diseases with Q8C779

No regional properties for Q8C779

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8C779

Functions

Description
EC Number
Subcellular Localization
  • Chromosome
  • Recruited to replication forks
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
replication fork The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.

1 GO annotations of molecular function

Name Definition
single-stranded DNA binding Binding to single-stranded DNA.

2 GO annotations of biological process

Name Definition
negative regulation of double-strand break repair via homologous recombination Any process that stops, prevents, or reduces the frequency, rate or extent of double-strand break repair via homologous recombination.
regulation of DNA repair Any process that modulates the frequency, rate or extent of DNA repair.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6NSI4 RADX RPA-related protein RADX Homo sapiens (Human) PR
B2GV47 Radx RPA-related protein RADX Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MSGESGQPQP GPSHAGLYLE HPERDQAGVP GGVIRRADSQ RRRSWIQKVI EQITGSPRQC
70 80 90 100 110 120
VTLSEVVPVT VLAVQRYLLE DEPRDTVPKP PLYCYDVTIS DGVYQEKCYL DPSLNFLVYQ
130 140 150 160 170 180
NILKVGIEMR ISRVSCLYNE KRLGQGILCI DKVHCGESLD VISVETPFRN RAHEEKPERP
190 200 210 220 230 240
LRGGKSHYLA LWNNEDPYGD IWKTNKQPEE FNFNNIKIIS LSHLELTWNS RKNFPALLVR
250 260 270 280 290 300
VLHKSKLRYY GKPNKKMIEP YQTYLEVADS SGMVSVILWN ALCPEWYKSL RVGLVLLLQD
310 320 330 340 350 360
YTVKKSYPLR IQPDPADPQM KLISTMEICL NLRDPPTNIV IIPEKQLKSE WKLPKLINRF
370 380 390 400 410 420
ITRSELDDMP EKSICDVIGL LSFVGRVQRS KKKENSEDFW SYRWIHITDG TSEQPFIVQL
430 440 450 460 470 480
FSTSQPEVFE NIYPMTYFVC TQLKVVRNNS QVPKLLYLTT TNESRALTTG GHRGLPYTYD
490 500 510 520 530 540
TKAKKIIQWI KTKTNLEAKN TVIGGYYPYP PVPETFSKYS RFIKAESLLT TISEVKKVIE
550 560 570 580 590 600
DLQYREQKRI AIQGIITAIK YIPYKHSAGS APAPEAFWNA SRPSTSQAAG KEDHCHERGS
610 620 630 640 650 660
KRSQDDRPMG SQHFQYTSKV LSLCAKRKIL QGPSANPVPV PQPHSSAQMK GSKHNTPSQE
670 680 690 700 710 720
SSTAYTTGKS RRITNDRWES QLWQDKKFSL RDHLHYGHVD PESIPRKFIL EHEKFLTQQF
730 740 750 760 770 780
NSQPAKYIPP EGKPPKLDEF QSARSLGHFE VTILGLNHEI AIDVAFLPMY SPEDVQASQI
790 800 810 820 830 840
DTFLTCMNFS CVYPPAAPLS GRLPDPKAVA GDIVKAAADL DRVHIIGILD ICNLGNNKVE
VCLQKIYTPE