Q8BY35
PR
Gene name |
Fgd2 |
Protein name |
FYVE, RhoGEF and PH domain-containing protein 2 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:26382 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BY35
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BY35-F1 | Predicted | AlphaFoldDB |
28 variants for Q8BY35
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389416575 | 19 | E>D | No | EVA | |
| rs47046273 | 39 | S>I | No | EVA | |
| rs3406642801 | 42 | H>P | No | EVA | |
| rs3389454472 | 89 | Q>H | No | EVA | |
| rs3389416656 | 93 | S>G | No | EVA | |
| rs3389441226 | 94 | P>A | No | EVA | |
| rs3389428343 | 173 | V>A | No | EVA | |
| rs3389446405 | 186 | I>F | No | EVA | |
| rs3389428294 | 211 | A>V | No | EVA | |
| rs108286637 | 234 | S>G | No | EVA | |
| rs215029179 | 235 | S>N | No | EVA | |
| rs3389454517 | 263 | L>M | No | EVA | |
| rs3389416570 | 276 | A>G | No | EVA | |
| rs3389439237 | 299 | G>S | No | EVA | |
| rs3389464952 | 357 | Q>H | No | EVA | |
| rs3389441173 | 361 | Q>H | No | EVA | |
| rs3389398858 | 386 | S>T | No | EVA | |
| rs3407903218 | 392 | K>Q | No | EVA | |
| rs3389443739 | 404 | D>Y | No | EVA | |
| rs3389460028 | 438 | T>M | No | EVA | |
| rs256289088 | 454 | Q>* | No | EVA | |
| rs3389428313 | 473 | A>V | No | EVA | |
| rs3389408071 | 492 | C>Y | No | EVA | |
| rs3389454538 | 532 | G>D | No | EVA | |
| rs45986438 | 543 | E>D | No | EVA | |
| rs3389398863 | 646 | E>Q | No | EVA | |
| rs3407546588 | 648 | P>S | No | EVA | |
| rs3406642792 | 649 | D>G | No | EVA |
No associated diseases with Q8BY35
7 regional properties for Q8BY35
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Dbl homology (DH) domain | 102 - 290 | IPR000219 |
| domain | FYVE zinc finger | 450 - 519 | IPR000306 |
| domain | Pleckstrin homology domain | 319 - 420 | IPR001849-1 |
| domain | Pleckstrin homology domain | 544 - 643 | IPR001849-2 |
| domain | Zinc finger, FYVE-related | 458 - 518 | IPR017455 |
| domain | FGD1-4, C-terminal PH domain | 538 - 640 | IPR035941 |
| domain | FGD2, N-terminal PH domain | 320 - 427 | IPR037797 |
Functions
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| early endosome membrane | The lipid bilayer surrounding an early endosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| ruffle | Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. |
| ruffle membrane | The portion of the plasma membrane surrounding a ruffle. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
| metal ion binding | Binding to a metal ion. |
| phosphatidylinositol phosphate binding | Binding to phosphatidylinositol phosphate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. |
| filopodium assembly | The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. |
| positive regulation of JUN kinase activity | Any process that activates or increases the frequency, rate or extent of JUN kinase activity. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5JSP0 | FGD3 | FYVE, RhoGEF and PH domain-containing protein 3 | Homo sapiens (Human) | PR |
| P98174 | FGD1 | FYVE, RhoGEF and PH domain-containing protein 1 | Homo sapiens (Human) | PR |
| Q7Z6J4 | FGD2 | FYVE, RhoGEF and PH domain-containing protein 2 | Homo sapiens (Human) | PR |
| P52734 | Fgd1 | FYVE, RhoGEF and PH domain-containing protein 1 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MERACEKQDS | VCNLVAVFEN | NRTPGEAPGS | HSLEDQPHSP | EHQLSLSPEP | WEAPPVKEAL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KSEFRPVSRT | YLSSLKNKLS | SGAWRRSCQP | GVSPGPETQE | PEEKRVVREL | LETEQAYVAR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LHLLDQVFFQ | ELLREAGRSK | AFPEDVVKLI | FSNISSIYRF | HAQFFLPELQ | RRVDDWAATP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RIGDVIQKLA | PFLKMYSEYV | KNFERAAELL | ATWMDKSQPF | QEVVTRIQCS | EASSSLTLQH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HMLEPVQRIP | RYELLLKEYV | QKLPAQAPDL | EDAQRALDMI | FSAAQHSNAA | IAEMERLQGL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| WDVYQRLGLE | DDIVDPSNTL | LREGPVLKIS | FRRSDPMERY | LVLFNNMLLY | CVPRVLQVGA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QFQVRTRIDV | AGMKVRELTD | AEFPHSFLVS | GKQRTLELQA | RSRDEMVSWM | QACQAAIDQV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EKRSETFKAA | VQGPQGDTQE | PKPQVEELGL | RAPQWVRDKM | VTMCMRCQEP | FNALTRRRHH |
| 490 | 500 | 510 | 520 | 530 | 540 |
| CRACGYVVCA | KCSDYRAELK | YDSNRPNRVC | LTCYTFLTGN | VLPQGKEDKR | RGILEKEASA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| APEQSLVCSF | LQLIGDKCSR | SLPRSWCVIP | RDDPLVLYVY | AAPQDTKAHT | SIPLLGYQVI |
| 610 | 620 | 630 | 640 | 650 | |
| SGPQGDPRVF | QLQQSGQQYT | FKAESVELQG | RWVTAIKRAA | SGRTPEGPDE | EDVSD |