P52734
PR
Gene name |
Fgd1 |
Protein name |
FYVE, RhoGEF and PH domain-containing protein 1 |
Names |
Faciogenital dysplasia 1 protein homolog, Rho/Rac guanine nucleotide exchange factor FGD1, Rho/Rac GEF, Zinc finger FYVE domain-containing protein 3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:14163 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P52734
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P52734-F1 | Predicted | AlphaFoldDB |
70 variants for P52734
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3412237647 | 60 | F>L | No | EVA | |
| rs3409599208 | 68 | L>P | No | EVA | |
| rs3389572041 | 147 | R>H | No | EVA | |
| rs29295112 | 154 | A>T | No | EVA | |
| rs1134694304 | 161 | V>A | No | EVA | |
| rs1133411956 | 162 | P>H | No | EVA | |
| rs3412141607 | 164 | K>R | No | EVA | |
| rs3389588617 | 170 | M>K | No | EVA | |
| rs3389578891 | 186 | R>L | No | EVA | |
| rs3389588609 | 187 | P>T | No | EVA | |
| rs3389557462 | 194 | V>M | No | EVA | |
| rs29295109 | 199 | V>A | No | EVA | |
| rs3412338326 | 207 | S>R | No | EVA | |
| rs3412239456 | 209 | A>E | No | EVA | |
| rs3412141642 | 210 | A>E | No | EVA | |
| rs3411904716 | 211 | V>A | No | EVA | |
| rs3389577178 | 211 | V>L | No | EVA | |
| rs3411005591 | 213 | S>* | No | EVA | |
| rs3389579517 | 223 | V>L | No | EVA | |
| rs3389574355 | 332 | S>F | No | EVA | |
| rs3412728343 | 357 | P>S | No | EVA | |
| rs3389579509 | 396 | Q>H | No | EVA | |
| rs3389583202 | 400 | A>T | No | EVA | |
| rs3389577189 | 402 | L>P | No | EVA | |
| rs3389577218 | 413 | P>L | No | EVA | |
| rs3411505982 | 418 | H>D | No | EVA | |
| rs3412274626 | 434 | F>L | No | EVA | |
| rs3412141675 | 434 | F>V | No | EVA | |
| rs3409599519 | 434 | F>Y | No | EVA | |
| rs3412239416 | 437 | P>A | No | EVA | |
| rs3411005586 | 437 | P>L | No | EVA | |
| rs3389578871 | 473 | F>L | No | EVA | |
| rs3389572108 | 517 | Q>L | No | EVA | |
| rs3412239459 | 545 | K>N | No | EVA | |
| rs3411505957 | 547 | L>M | No | EVA | |
| rs3412141663 | 548 | E>A | No | EVA | |
| rs3389545911 | 556 | H>R | No | EVA | |
| rs3389487477 | 579 | G>V | No | EVA | |
| rs3389487531 | 627 | L>V | No | EVA | |
| rs3389572099 | 632 | F>S | No | EVA | |
| rs3389588629 | 634 | V>M | No | EVA | |
| rs3412361644 | 636 | A>T | No | EVA | |
| rs3389579550 | 639 | D>N | No | EVA | |
| rs3389572081 | 639 | D>V | No | EVA | |
| rs3389545833 | 663 | Q>H | No | EVA | |
| rs3389578842 | 664 | R>H | No | EVA | |
| rs3389573621 | 691 | E>K | No | EVA | |
| rs3389574377 | 698 | K>R | No | EVA | |
| rs3389577160 | 701 | N>Y | No | EVA | |
| rs3389557507 | 705 | R>G | No | EVA | |
| rs3402728419 | 715 | P>T | No | EVA | |
| rs3389588573 | 749 | R>G | No | EVA | |
| rs3389573591 | 764 | S>Y | No | EVA | |
| rs3389487513 | 780 | V>M | No | EVA | |
| rs3389578014 | 791 | A>E | No | EVA | |
| rs3389578863 | 800 | Q>H | No | EVA | |
| rs3389578006 | 804 | Q>R | No | EVA | |
| rs3389572035 | 820 | N>I | No | EVA | |
| rs3412339337 | 829 | Y>H | No | EVA | |
| rs3412458611 | 830 | M>T | No | EVA | |
| rs3389545923 | 857 | A>T | No | EVA | |
| rs3389573624 | 872 | F>L | No | EVA | |
| rs3389588597 | 875 | G>R | No | EVA | |
| rs3389573557 | 887 | H>Y | No | EVA | |
| rs3389588620 | 896 | L>V | No | EVA | |
| rs3411904880 | 908 | Q>K | No | EVA | |
| rs3412728442 | 908 | Q>R | No | EVA | |
| rs3412141626 | 910 | R>P | No | EVA | |
| rs3412276347 | 911 | W>R | No | EVA | |
| rs3389545842 | 917 | R>M | No | EVA |
No associated diseases with P52734
2 regional properties for P52734
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Polyprenyl synthetase, conserved site | 90 - 104 | IPR033749-1 |
| conserved_site | Polyprenyl synthetase, conserved site | 224 - 236 | IPR033749-2 |
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| lamellipodium | A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. |
| ruffle | Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
| metal ion binding | Binding to a metal ion. |
| small GTPase binding | Binding to a small monomeric GTPase. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. |
| filopodium assembly | The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. |
| regulation of cell shape | Any process that modulates the surface configuration of a cell. |
| regulation of GTPase activity | Any process that modulates the rate of GTP hydrolysis by a GTPase. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5JSP0 | FGD3 | FYVE, RhoGEF and PH domain-containing protein 3 | Homo sapiens (Human) | PR |
| Q7Z6J4 | FGD2 | FYVE, RhoGEF and PH domain-containing protein 2 | Homo sapiens (Human) | PR |
| P98174 | FGD1 | FYVE, RhoGEF and PH domain-containing protein 1 | Homo sapiens (Human) | PR |
| Q8BY35 | Fgd2 | FYVE, RhoGEF and PH domain-containing protein 2 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MHGHRVPGGP | GPSDPERSAA | NTPGAAPLAC | ADSDPGALEP | GLPVSRGSGT | ALGGPLDPQF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VGPSDASLGA | PPSSRVLPCG | PSPQHHRALR | FSYHLEGSQP | RPGLHQGNRI | LVKSLSLDPG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QSLEPHPEGP | QRLRSDPGPP | TEIPGPRPSP | LKRAPGPKPQ | VPPKPSYLQM | PRVLPPPEPI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PPPPSRPLPA | DPRVAKGLVP | RAEASTSSAA | VSSLIEKFER | EPVIVASDRP | APGPCPVPPE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PAMLPQPPPQ | PTGSQLPEGE | ASRCLFLLAP | GPRDGEKVPN | RDSGIDSISS | PSNSEETCFV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SDDGPPIHSL | CPGPPALASM | PVALADPHRP | GSQEVDSDLE | EEEEEEEEEK | EREIPVPPME |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RQESVELTVQ | QKVFHIANEL | LQTEKAYVSR | LHLLDQVFCA | RLLEEARNRS | SFPADVVHGI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FSNICSIYCF | HQQFLLPELE | KRMEEWDRYP | RIGDILQKLA | PFLKMYGEYV | KNFDRAVELV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NTWTERSTQF | KVIIHEVQKE | EACGNLTLQH | HMLEPVQRIP | RYELLLKDYL | LKLPHGSPDS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KDAQKSLELI | ATAAEHSNAA | IRKMERMHKL | LKVYELLGGE | EDIVSPTKEL | IKEGHILKLS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| AKNGTTQDRY | LILFNDRLLY | CVPRLRLLGQ | KFSVRARIDV | DGMELKESSN | LNMPRTFLVS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GKQRSLELQA | RTEEEKKDWV | QAINSTLLKH | EQTLETFKLL | NSTNRDDEDT | PPNSPNVDLG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KRAPTPIREK | EVTMCMRCQE | PFNSITKRRH | HCKACGHVVC | GKCSEFRARL | IYDNNRSNRV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| CTDCYVALHG | APGSSPACSQ | HTPQRRRSIL | EKQASVAAEN | SVICSFLHYM | EKGGKGWHKA |
| 850 | 860 | 870 | 880 | 890 | 900 |
| WFVVPENEPL | VLYIYGAPQD | VKAQRSLPLI | GFEVGPPEAG | ERPDRRHVFK | ITQSHLSWYF |
| 910 | 920 | 930 | 940 | 950 | |
| SPETEELQRR | WMAVLGRAGR | GDTFCPGPTL | SEDKEMEETP | VAASGATAEP | PEASQTRDKT |