Q8BWB6
Gene name |
Steap2 |
Protein name |
Metalloreductase STEAP2 |
Names |
Six-transmembrane epithelial antigen of prostate 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:74051 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BWB6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BWB6-F1 | Predicted | AlphaFoldDB |
29 variants for Q8BWB6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388741137 | 3 | S>F | No | EVA | |
| rs3388739408 | 66 | S>L | No | EVA | |
| rs3388740902 | 96 | H>Y | No | EVA | |
| rs3388728916 | 99 | S>T | No | EVA | |
| rs3388743002 | 117 | N>K | No | EVA | |
| rs3388742817 | 132 | L>Q | No | EVA | |
| rs3388748042 | 171 | I>S | No | EVA | |
| rs3388734561 | 173 | A>S | No | EVA | |
| rs3388742859 | 215 | V>G | No | EVA | |
| rs3388742547 | 217 | V>E | No | EVA | |
| rs3388747985 | 232 | R>G | No | EVA | |
| rs3388748050 | 249 | I>V | No | EVA | |
| rs3388740872 | 250 | P>L | No | EVA | |
| rs3388746772 | 286 | K>* | No | EVA | |
| rs3388742990 | 288 | R>C | No | EVA | |
| rs3388715078 | 290 | F>L | No | EVA | |
| rs3395231742 | 297 | W>C | No | EVA | |
| rs3394889028 | 297 | W>L | No | EVA | |
| rs3395179110 | 299 | Q>H | No | EVA | |
| rs3388733099 | 310 | F>Y | No | EVA | |
| rs3388743001 | 339 | Q>H | No | EVA | |
| rs3388748001 | 343 | N>I | No | EVA | |
| rs3388739357 | 347 | A>T | No | EVA | |
| rs3388728777 | 356 | I>F | No | EVA | |
| rs3388715088 | 389 | E>V | No | EVA | |
| rs3388742839 | 405 | T>M | No | EVA | |
| rs3388742973 | 425 | F>L | No | EVA | |
| rs30983517 | 455 | R>Q | No | EVA | |
| rs3388746768 | 484 | E>A | No | EVA |
No associated diseases with Q8BWB6
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| endosome membrane | The lipid bilayer surrounding an endosome. |
| integral component of Golgi membrane | The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| trans-Golgi network transport vesicle | A vesicle that mediates transport between the trans-Golgi network and other parts of the cell. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| cupric reductase activity | Catalysis of the reaction: Cu+ + NAD+ + H+ = Cu2+ + NADH. |
| ferric-chelate reductase (NADPH) activity | Catalysis of the reaction: 2 Fe3+-siderophore + NADP(+) + H(+) -> 2 Fe2+-siderophore + NADPH. |
| metal ion binding | Binding to a metal ion. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| copper ion import | The directed movement of copper ions into a cell or organelle. |
| copper ion import across plasma membrane | The directed movement of copper ions from outside of a cell, across the plasma membrane and into the cytosol. |
| endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. |
| Golgi to plasma membrane transport | The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis. |
| iron ion import across cell outer membrane | The directed movement of iron ions from outside of a cell, across the cell outer membrane and into the periplasmic space. |
| iron ion import across plasma membrane | The directed movement of iron ions from outside of a cell, across the plasma membrane and into the cytosol. |
| regulated exocytosis | A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand. |
| response to hormone | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q658P3 | STEAP3 | Metalloreductase STEAP3 | Homo sapiens (Human) | PR |
| Q8NFT2 | STEAP2 | Metalloreductase STEAP2 | Homo sapiens (Human) | PR |
| Q9UHE8 | STEAP1 | Metalloreductase STEAP1 | Homo sapiens (Human) | PR |
| Q8CI59 | Steap3 | Metalloreductase STEAP3 | Mus musculus (Mouse) | PR |
| Q9GL50 | STEAP1 | Metalloreductase STEAP1 | Sus scrofa (Pig) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MESISMMGSP | KSLETFLPNG | INGIKDARQV | TVGVIGSGDF | AKSLTIRLIR | CGYHVVIGSR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NPKFASEFFP | HVVDVTHHED | ALTKTNIIFV | AIHREHYTSL | WDLRHLLVGK | ILIDVSNNMR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VNQYPESNAE | YLASLFPDSL | IVKGFNVISA | WALQLGPKDA | SRQVYICSNN | IQARQQVIEL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ARQLNFIPVD | LGSLSSAKEI | ENLPLRLFTL | WRGPVVVAIS | LATFFFLYSF | VRDVIHPYAR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NQQSDFYKIP | IEIVNKTLPI | VAITLLSLVY | LAGLLAAAYQ | LYYGTKYRRF | PPWLDTWLQC |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RKQLGLLSFF | FAVVHVAYSL | CLPMRRSERY | LFLNMAYQQV | HANIENAWNE | EEVWRIEMYI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SFGIMSLGLL | SLLAVTSIPS | VSNALNWREF | SFIQSTLGYV | ALLITTFHVL | IYGWKRAFAE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EYYRFYTPPN | FVLALVLPSI | VILGKMILLL | PCISRKLKRI | KKGWEKSQFL | DEGMGGAVPH |
| LSPERVTVM |