Q9GL50
Gene name |
STEAP1 (STEAP) |
Protein name |
Metalloreductase STEAP1 |
Names |
Six transmembrane endothelial antigen of PAEC, Six-transmembrane epithelial antigen of prostate 1 |
Species |
Sus scrofa (Pig) |
KEGG Pathway |
ssc:397573 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9GL50
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9GL50-F1 | Predicted | AlphaFoldDB |
7 variants for Q9GL50
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs339857088 | 38 | K>Q | No | EVA | |
| rs325231618 | 68 | P>S | No | EVA | |
| rs712411910 | 80 | V>M | No | EVA | |
| rs704707985 | 99 | T>S | No | EVA | |
| rs331636810 | 279 | I>V | No | EVA | |
| rs323420444 | 314 | R>K | No | EVA | |
| rs690621360 | 321 | H>R | No | EVA |
No associated diseases with Q9GL50
1 regional properties for Q9GL50
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Ferric reductase transmembrane component-like domain | 118 - 263 | IPR013130 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| endosome membrane | The lipid bilayer surrounding an endosome. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| ion transport | The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| iron ion homeostasis | Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9UHE8 | STEAP1 | Metalloreductase STEAP1 | Homo sapiens (Human) | PR |
| Q658P3 | STEAP3 | Metalloreductase STEAP3 | Homo sapiens (Human) | PR |
| Q8NFT2 | STEAP2 | Metalloreductase STEAP2 | Homo sapiens (Human) | PR |
| Q8BWB6 | Steap2 | Metalloreductase STEAP2 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MESRQDITNQ | EELWKMKPRK | NLEDDYLNED | SRENSMPKRP | MLVHLHQTAH | FDEFDCPPEL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QHKQELFPKW | HLPIKIAAIV | SSLTFLYTLL | REVIHPFVTS | HQQYFYKIPI | LVINKVLPMV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SITLLALVYL | PGVIAAIVQL | HNGTKYKKFP | HWLDRWMVTR | KQFGLLSFFF | AVLHAVYSLS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YPMRRSYRYK | LLNWAYQQVQ | QNKEDAWIEH | DVWRMEIYVS | LGIVTLAILA | LLAVTSIPSV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SDSLTWREFH | YIQSTLGIVS | LLLGTIHALI | FAWNKWVDIK | QFIWYTPPTF | MIAVFLPTVV |
| 310 | 320 | 330 | |||
| LICKVILLLP | CLRRKILKIR | HGWEDVTKIN | KTEMSSQL |