Q8BS95
Gene name |
Gpr89 |
Protein name |
Golgi pH regulator |
Names |
Protein GPR89 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:67549 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BS95
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BS95-F1 | Predicted | AlphaFoldDB |
18 variants for Q8BS95
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388652076 | 12 | T>I | No | EVA | |
| rs3388647653 | 190 | E>* | No | EVA | |
| rs3388643954 | 192 | R>P | No | EVA | |
| rs3388650308 | 197 | M>K | No | EVA | |
| rs3388649497 | 207 | M>V | No | EVA | |
| rs3388653121 | 226 | G>* | No | EVA | |
| rs3388652052 | 227 | L>F | No | EVA | |
| rs3388647637 | 227 | L>P | No | EVA | |
| rs3388631931 | 230 | M>I | No | EVA | |
| rs3413147252 | 310 | L>I | No | EVA | |
| rs3388645950 | 310 | L>R | No | EVA | |
| rs3388651258 | 312 | R>G | No | EVA | |
| rs3388650378 | 313 | V>* | No | EVA | |
| rs3393491801 | 359 | L>V | No | EVA | |
| rs3388645532 | 365 | K>N | No | EVA | |
| rs3388652037 | 383 | L>F | No | EVA | |
| rs3388653150 | 401 | S>I | No | EVA | |
| rs3388652045 | 456 | P>C | No | EVA |
No associated diseases with Q8BS95
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| Golgi cisterna membrane | The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| Golgi-associated vesicle membrane | The lipid bilayer surrounding a vesicle associated with the Golgi apparatus. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| voltage-gated anion channel activity | Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular pH reduction | Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of ion transmembrane transport | Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. |
| skin development | The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. |
| T cell differentiation | The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P38799 | YHR078W | Uncharacterized protein YHR078W | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q5BIM9 | GPR89 | Golgi pH regulator | Bos taurus (Bovine) | PR |
| Q5F448 | GPR89 | Golgi pH regulator | Gallus gallus (Chicken) | PR |
| P0CG08 | GPR89B | Golgi pH regulator B | Homo sapiens (Human) | PR |
| B7ZAQ6 | GPR89A | Golgi pH regulator A | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSFLIDSSIM | ITSQILFFGF | GWLFFMRQLF | KDYEVRQYVV | QVIFSVTFAF | SCTMFELIIF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EILGVLNSSS | RYFHWKLNLC | VILLILVFMV | PFYIGYFIVS | NIQLLHKQRL | LFSCLLWLTF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MYFFWKLGDP | FPILSPKHGI | LSIEQLISRV | GVIGVTLMAL | LSGFGAVNCP | YTYMSYFLRN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VTDTDILALE | RRLLQTMDMI | ISKKKRMAVA | RRTMFQRGDV | QNKPSGLWGM | LKSVTASAPG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SENLTLIQQE | VDALEELSRQ | LFLETADLYA | TKERIEYSKT | FKGKYFNFLG | YFFSIYCVWK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IFMATINIVL | DRVGKTDPVT | RGIEITVNYL | GIQFDVKFWS | QHISFILVGI | IIVTSIRGLL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ITLTKFFYAI | SSSKSSNVIV | LLLAQIMGMY | FVSSVLLIRM | SMPPEYRTII | TEVLGELQFN |
| 430 | 440 | 450 | |||
| FYHRWFDVIF | LVSALSSILF | LYLAHKQAPE | KHMAP |