Q5BIM9

PR
Gene name
GPR89 (GPHR, GPR89A)
Protein name
Golgi pH regulator
Names
Protein GPR89
Species
Bos taurus (Bovine)
KEGG Pathway
bta:767859
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

172-271 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5BIM9

Entry ID Method Resolution Chain Position Source
AF-Q5BIM9-F1 Predicted AlphaFoldDB

No variants for Q5BIM9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5BIM9

No associated diseases with Q5BIM9

No regional properties for Q5BIM9

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q5BIM9

Functions

Description
EC Number
Subcellular Localization
  • Golgi apparatus membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
Golgi cisterna membrane The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
Golgi-associated vesicle membrane The lipid bilayer surrounding a vesicle associated with the Golgi apparatus.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
voltage-gated anion channel activity Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

4 GO annotations of biological process

Name Definition
intracellular pH reduction Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of ion transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.
T cell differentiation The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38799 YHR078W Uncharacterized protein YHR078W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q5F448 GPR89 Golgi pH regulator Gallus gallus (Chicken) PR
P0CG08 GPR89B Golgi pH regulator B Homo sapiens (Human) PR
B7ZAQ6 GPR89A Golgi pH regulator A Homo sapiens (Human) PR
Q8BS95 Gpr89 Golgi pH regulator Mus musculus (Mouse) PR
10 20 30 40 50 60
MSFLIDSSIM ITSQILFFGF GWLFFMRQLF KDYEVRQYVV QVIFSVTFAF SCTMFELIIF
70 80 90 100 110 120
EILGVLNSSS RYFHWKMNLC VILLILVFMV PFYIGYFIVS NIRLLHKQRL LFSCLLWLTF
130 140 150 160 170 180
MYFFWKLGDP FPILSPKHGI LSIEQLISRV GVIGVTLMAL LSGFGAVNCP YTYMSYFLRN
190 200 210 220 230 240
VTDTDILALE RRLLQTMDMI ISKKKRMAMT RRTMFQKGEV HNKPSGFWGM IKSVTTSAPG
250 260 270 280 290 300
SENLTLIQQE VDALEELSRQ LFLETADLYA TKERIEYSKT FKGKYFNFLG YFFSIYCVWK
310 320 330 340 350 360
IFMATINIVF DRVGKTDPVT RGIEITVNYL GIQFDVKFWS QHISFILVGI IIVTSIRGLL
370 380 390 400 410 420
ITLTKFFYAI SSSKSSNVIV LLLAQIMGMY FVSSVLLIRM SMPLEYRTII TEVLGELQFN
430 440 450
FYHRWFDVIF LVSALSSILF LYLAHKQAPE KHMAP