AiPD: Autoinhibited Protein Database

Gene name	Phf20 (Hca58)
Protein name	PHD finger protein 20
Names	Hepatocellular carcinoma-associated antigen 58 homolog
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:228829
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

114-188 (Predicted disordered autoinhibitory region) PR

114-188 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8BLG0-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388596642	57	W>R	No	EVA
rs3392136458	90	N>D	No	EVA
rs3392419685	92	Q>ASTCWFI*	No	EVA
rs3392419685	93	V>E	No	EVA
rs3392471473	93	V>E	No	EVA
rs3392503671	95	A>T	No	EVA
rs3388596697	117	T>I	No	EVA
rs3388604594	173	T>M	No	EVA
rs586039672	179	D>E	No	EVA
rs1134791568	190	R>Q	No	EVA
rs1132558190	205	K>N	No	EVA
rs1133060557	228	E>K	No	EVA
rs242923733	247	K>R	No	EVA
rs13476860	248	N>S	No	EVA
rs3388600041	255	E>K	No	EVA
rs1134731583	263	P>L	No	EVA
rs3392368336	268	P>S	No	EVA
rs3388600049	298	L>I	No	EVA
rs3388590479	304	D>H	No	EVA
rs3388607197	318	N>Y	No	EVA
rs3388604721	333	T>A	No	EVA
rs239476987	344	S>L	No	EVA
rs3388605515	361	K>R	No	EVA
rs228544768	384	S>C	No	EVA
rs252205561	388	C>G	No	EVA
rs585641157	389	H>P	No	EVA
rs581889813	399	D>A	No	EVA
rs3388602571	446	V>M	No	EVA
rs3412824812	474	Y>F	No	EVA
rs3388597316	535	K>N	No	EVA
rs3388606985	565	S>R	No	EVA
rs3388607491	593	S>R	No	EVA
rs3392338532	600	D>N	No	EVA
rs218151613	652	D>N	No	EVA
rs3392430924	676	Q>P	No	EVA
rs3392280619	678	W>C	No	EVA
rs3392338537	681	G>W	No	EVA
rs3392457551	682	V>D	No	EVA
rs3392280623	682	V>L	No	EVA
rs3388607477	691	V>M	No	EVA
rs3388597282	708	P>H	No	EVA
rs3388590525	708	P>S	No	EVA
rs263010890	731	D>E	No	EVA
rs3388608311	737	Q>K	No	EVA
rs3392338451	739	A>TIFLAFWWE*	No	EVA
rs3388597257	751	D>G	No	EVA
rs3388606742	763	Q>H	No	EVA
rs3388606175	787	H>R	No	EVA
rs3388590547	790	E>K	No	EVA
rs1133272615	794	H>Y	No	EVA
rs583748471	803	A>T	No	EVA
rs237772575	817	A>T	No	EVA
rs3392503632	818	V>M	No	EVA
rs3392448631	822	S>P	No	EVA
rs3388598191	824	L>P	No	EVA
rs3388607241	826	R>L	No	EVA
rs3388604667	828	V>A	No	EVA
rs3388602117	836	E>G	No	EVA
rs3388598151	903	V>G	No	EVA
rs3392368335	950	E>V*	No	EVA
rs3388606681	989	H>R	No	EVA

Type	Name	Position	InterPro Accession
domain	Zinc finger, PHD-type	657 - 701	IPR001965
domain	Tudor domain	11 - 71	IPR002999-1
domain	Tudor domain	85 - 141	IPR002999-2
domain	Zinc finger C2H2-type	455 - 485	IPR013087
conserved_site	Zinc finger, PHD-type, conserved site	658 - 700	IPR019786
domain	PHD finger protein 20, AT hook	176 - 280	IPR022255
domain	DNA repair protein Crb2, Tudor domain	90 - 136	IPR041297

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
histone acetyltransferase complex	A protein complex that possesses histone acetyltransferase activity.
MLL1 complex	A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.
NSL complex	A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residues at several positions. In human, it contains the catalytic subunit MOF, NSL1/KIAA1267, NSL2/KANSL2, NSL3/KANSL3, MCRS1, PHF20, OGT1, WDR5 and HCF1.
nuclear membrane	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
metal ion binding	Binding to a metal ion.

Name	Definition
chromatin organization	The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
histone acetylation	The modification of a histone by the addition of an acetyl group.
histone H4-K16 acetylation	The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone.
histone H4-K5 acetylation	The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 of the histone.
histone H4-K8 acetylation	The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone.
positive regulation of DNA-templated transcription	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of histone H3-K4 methylation	Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3.
regulation of dosage compensation by inactivation of X chromosome	Any process that modulates the frequency, rate or extent of dosage compensation, by inactivation of X chromosome.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A2VE56	PHF20L1	PHD finger protein 20-like protein 1	Bos taurus (Bovine)	PR
Q9BVI0	PHF20	PHD finger protein 20	Homo sapiens (Human)	PR