Q8BL95
Gene name |
Cfap298 |
Protein name |
Cilia- and flagella-associated protein 298 |
Names |
Protein kurly homolog |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:68001 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BL95
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BL95-F1 | Predicted | AlphaFoldDB |
19 variants for Q8BL95
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389426433 | 47 | E>V | No | EVA | |
| rs3389427012 | 48 | M>SDG* | No | EVA | |
| rs13460664 | 59 | P>H | No | EVA | |
| rs3389426404 | 60 | P>L | No | EVA | |
| rs3389419138 | 63 | Q>* | No | EVA | |
| rs3389418795 | 69 | Q>H | No | EVA | |
| rs249233350 | 95 | E>D | No | EVA | |
| rs3389386042 | 112 | L>F | No | EVA | |
| rs3389435680 | 125 | K>T | No | EVA | |
| rs6205188 | 128 | V>I | No | EVA | |
| rs3389442329 | 135 | T>S | No | EVA | |
| rs3389442295 | 151 | M>L | No | EVA | |
| rs3389406256 | 188 | E>D | No | EVA | |
| rs3389426961 | 236 | S>N | No | EVA | |
| rs3389435695 | 246 | Y>N | No | EVA | |
| rs3389426381 | 256 | L>V | No | EVA | |
| rs3389435613 | 272 | N>H | No | EVA | |
| rs3389431691 | 277 | R>G | No | EVA | |
| rs3389394563 | 288 | R>Q | No | EVA |
No associated diseases with Q8BL95
No regional properties for Q8BL95
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8BL95 | |||
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cilium | A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cilium assembly | The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. |
| regulation of cilium movement | Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P57076 | CFAP298 | Cilia- and flagella-associated protein 298 | Homo sapiens (Human) | PR |
| Q5U3Z0 | Cfap298 | Cilia- and flagella-associated protein 298 | Rattus norvegicus (Rat) | PR |
| Q6DRC3 | cfap298 | Cilia- and flagella-associated protein 298 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVVLHVKRGD | ESQFLLQAPG | STELEELTAQ | VARVYNGRLK | VHRLCSEMEE | LAEHGVFLPP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NMQGLTDEQI | EELKLKDEWG | EKCVPSGGSV | FTKDEIGRRN | GQAPNEKMKQ | VLKKTVEEAK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AIVSKKQVEA | GVFVTMEMVK | DALDQLRGAV | MIVYPMGLPP | YDPIRMEFEN | KEDLSGTQAA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LEVIQESEAQ | LWWAAKELRR | TKKLSDYVGK | NEKTKIIVKI | QQRGQGAPAR | EPVISSEEHK |
| 250 | 260 | 270 | 280 | ||
| QLMLFYHRRQ | EELKKLEEND | DDSCLNSPWA | DNTALKRHFH | GVKDIKWRPR |