Q5U3Z0

PR
Gene name
Cfap298
Protein name
Cilia- and flagella-associated protein 298
Names
Protein kurly homolog
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:288269
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

68-155 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5U3Z0

Entry ID Method Resolution Chain Position Source
AF-Q5U3Z0-F1 Predicted AlphaFoldDB

No variants for Q5U3Z0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5U3Z0

No associated diseases with Q5U3Z0

No regional properties for Q5U3Z0

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q5U3Z0

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cytoplasm, cytoskeleton, cilium basal body
  • Partially colocalized with SASS6 in cytoplasmic puncta, suggesting a centrosomal localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cilium A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
cilium assembly The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
regulation of cilium movement Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P57076 CFAP298 Cilia- and flagella-associated protein 298 Homo sapiens (Human) PR
Q8BL95 Cfap298 Cilia- and flagella-associated protein 298 Mus musculus (Mouse) PR
Q6DRC3 cfap298 Cilia- and flagella-associated protein 298 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MVVLHVKRGD ESQFLLQAPG STELEELTAQ VTRVYNGRLK VHRLCTEIEE LAEHGVFLPP
70 80 90 100 110 120
NMQGLTDEQI EELKLKDEWG EKCVPSGGSV FTKDDIGRRN GHAPNEKMKQ VLKKTVEEAK
130 140 150 160 170 180
AMVSKKQVEA GVFVTMEMVK DALDQLRGAV MIVYPMGLPP YDPIRMEFEN KEDLSGTQAA
190 200 210 220 230 240
LEVIQESEAQ LWWAAKELRR TKKLSDYVGK NEKTKIIVKI QQRGQGAPAR EPLISSEEHK
250 260 270 280
QLMLFYHRRQ EELKKLEEND DDSCLNSPWA DNTALKRHFH GVKDIKWRPR