AiPD: Autoinhibited Protein Database

Gene name	Nup93 (Cip4, Kiaa0095)
Protein name	Nuclear pore complex protein Nup93
Names	93 kDa nucleoporin, CBP-interacting protein 4, Nucleoporin Nup93
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:71805
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

11-83 (Predicted disordered autoinhibitory region) PR

11-83 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8BJ71-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388997625	10	L>H	No	EVA
rs3388994918	21	E>V	No	EVA
rs3389006236	25	E>V	No	EVA
rs3389005392	50	R>L	No	EVA
rs3388989633	113	A>V	No	EVA
rs3388998678	117	S>T	No	EVA
rs3399447150	124	M>K	No	EVA
rs3389005356	131	E>G	No	EVA
rs3388993760	160	Q>P	No	EVA
rs3398546651	166	Y>N	No	EVA
rs3399005770	169	D>Y	No	EVA
rs3399394538	170	V>E	No	EVA
rs3399696765	170	V>M	No	EVA
rs3389002338	236	T>I	No	EVA
rs3388977857	257	Q>E	No	EVA
rs3388989651	305	S>P	No	EVA
rs3389006803	360	D>Y	No	EVA
rs3399394553	373	L>P	No	EVA
rs3388977900	393	I>T	No	EVA
rs3389001836	577	S>G	No	EVA
rs3399549109	615	V>L	No	EVA
rs3388970141	624	E>*	No	EVA
rs3388951479	625	A>V	No	EVA
rs3389005357	628	L>F	No	EVA
rs3389006792	654	S>C	No	EVA
rs3389002599	667	A>G	No	EVA
rs3388999910	689	F>I	No	EVA
rs3389005397	692	L>I	No	EVA
rs3389000153	708	D>A	No	EVA
rs3388952666	710	A>D	No	EVA
rs3389002357	736	N>I	No	EVA
rs3388995001	744	N>Y	No	EVA
rs3388994962	764	K>I	No	EVA
rs3389002609	809	A>D	No	EVA
rs3388952649	818	M>I	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q8BJ71

		Description
EC Number
Subcellular Localization	Nucleus membrane ; Peripheral membrane protein Nucleus, nuclear pore complex Nucleus envelope	Localizes at the nuclear basket and at or near the nuclear entry to the gated channel of the pore
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
centrosome	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
nuclear envelope	The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nuclear membrane	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nuclear periphery	The portion of the nuclear lumen proximal to the inner nuclear membrane.
nuclear pore	A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.

Name	Definition
structural constituent of nuclear pore	The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.

Name	Definition
nuclear envelope organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope.
nuclear pore complex assembly	The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex.
nucleocytoplasmic transport	The directed movement of molecules between the nucleus and the cytoplasm.
poly(A)+ mRNA export from nucleus	The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm.
positive regulation of SMAD protein signal transduction	Any process that increases the rate, frequency or extent of SMAD protein signal transduction. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
protein import into nucleus	The directed movement of a protein from the cytoplasm to the nucleus.
SMAD protein signal transduction	The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8N1F7	NUP93	Nuclear pore complex protein Nup93	Homo sapiens (Human)	PR
F4J284	NUP93B	Nuclear pore complex protein NUP93B	Arabidopsis thaliana (Mouse-ear cress)	PR