AiPD: Autoinhibited Protein Database

Gene name	Fbxw8
Protein name	F-box/WD repeat-containing protein 8
Names	F-box and WD-40 domain-containing protein 8
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:231672
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-132 (Predicted disordered autoinhibitory region) PR

1-132 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8BIA4-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs240571668	80	T>A	No	EVA
rs223509473	92	A>P	No	EVA
rs243192108	110	D>H	No	EVA
rs218128440	118	R>H	No	EVA
rs37232696	138	L>V	No	EVA
rs3388783017	196	K>E	No	EVA
rs3388778018	231	D>E	No	EVA
rs212787718	269	S>N	No	EVA
rs3388790157	270	S>W	No	EVA
rs3388786645	287	R>K	No	EVA
rs3388786290	299	D>N	No	EVA
rs3411306050	328	N>S	No	EVA
rs3396233888	455	R>M	No	EVA
rs3388767307	482	Q>L	No	EVA
rs3388779609	491	G>DG*	No	EVA
rs3388787182	491	G>V	No	EVA
rs3388780231	513	S>T	No	EVA
rs3388790193	525	H>Q	No	EVA
rs3388771019	553	R>H	No	EVA
rs3388786559	579	R>H	No	EVA
rs3396135305	590	A>V	No	EVA

Type	Name	Position	InterPro Accession
repeat	WD40 repeat	198 - 236	IPR001680-1
repeat	WD40 repeat	248 - 285	IPR001680-2
repeat	WD40 repeat	289 - 327	IPR001680-3
repeat	WD40 repeat	421 - 461	IPR001680-4
repeat	WD40 repeat	464 - 510	IPR001680-5
domain	F-box domain	113 - 161	IPR001810

		Description
EC Number
Subcellular Localization	Cytoplasm, perinuclear region Golgi apparatus	Colocalizes with CUL7 at the Golgi apparatus in neurons
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
3M complex	A protein complex, at least composed of CUL7, CCDC8 and OBSL1, that is required for maintaining microtubule and genome integrity.
Cul7-RING ubiquitin ligase complex	A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 linker and an F-box protein.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.
SCF ubiquitin ligase complex	A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).

Name	Definition
ubiquitin-protein transferase activity	Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.

Name	Definition
cell population proliferation	The multiplication or reproduction of cells, resulting in the expansion of a cell population.
Golgi organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
labyrinthine layer blood vessel development	The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply.
positive regulation of dendrite morphogenesis	Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis.
positive regulation of transcription factor catabolic process	Any process that activates or increases the frequency, rate or extent of transcription factor catabolic process.
protein ubiquitination	The process in which one or more ubiquitin groups are added to a protein.
spongiotrophoblast layer development	The process in which the spongiotrophoblast layer of the placenta progresses from its formation to its mature state.
ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q969H0	FBXW7	F-box/WD repeat-containing protein 7	Homo sapiens (Human)	PR
Q008S8	ECT2L	Epithelial cell-transforming sequence 2 oncogene-like	Homo sapiens (Human)	PR
Q8N3Y1	FBXW8	F-box/WD repeat-containing protein 8	Homo sapiens (Human)	PR
Q9QZM9	Fbxo16	F-box only protein 16	Mus musculus (Mouse)	PR
P0DL28	Fbxw8	F-box/WD repeat-containing protein 8	Rattus norvegicus (Rat)	PR