Q8BHY2
Gene name |
Noc4l |
Protein name |
Nucleolar complex protein 4 homolog |
Names |
NOC4 protein homolog, NOC4-like protein, Nucleolar complex-associated protein 4-like protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:100608 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BHY2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BHY2-F1 | Predicted | AlphaFoldDB |
23 variants for Q8BHY2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388770752 | 133 | P>S | No | EVA | |
| rs260777652 | 147 | R>H | No | EVA | |
| rs257377414 | 170 | H>Q | No | EVA | |
| rs37393923 | 174 | Y>C | No | EVA | |
| rs33754487 | 175 | L>M | No | EVA | |
| rs3395775069 | 187 | V>L | No | EVA | |
| rs3396006020 | 190 | S>G | No | EVA | |
| rs218618289 | 195 | A>S | No | EVA | |
| rs3396006031 | 197 | S>C | No | EVA | |
| rs3396035685 | 228 | N>I | No | EVA | |
| rs3395920059 | 233 | H>Y | No | EVA | |
| rs3388779352 | 256 | W>R | No | EVA | |
| rs3395642823 | 297 | A>T | No | EVA | |
| rs3388785290 | 335 | D>V | No | EVA | |
| rs3388785284 | 362 | A>P | No | EVA | |
| rs33539341 | 407 | R>H | No | EVA | |
| rs3388760124 | 415 | A>V | No | EVA | |
| rs36298920 | 421 | T>A | No | EVA | |
| rs237125913 | 429 | R>C | No | EVA | |
| rs3388776520 | 435 | L>V | No | EVA | |
| rs3388776476 | 451 | K>* | No | EVA | |
| rs3388779355 | 472 | E>K | No | EVA | |
| rs37558192 | 487 | M>I | No | EVA |
No associated diseases with Q8BHY2
1 regional properties for Q8BHY2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | CCAAT-binding factor | 305 - 453 | IPR005612 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| Noc4p-Nop14p complex | A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis. |
| nuclear membrane | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| small-subunit processome | A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| ribosome biogenesis | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q06512 | NOC4 | Nucleolar complex protein 4 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q5ZJC7 | NOC4L | Nucleolar complex protein 4 homolog | Gallus gallus (Chicken) | PR |
| Q9BVI4 | NOC4L | Nucleolar complex protein 4 homolog | Homo sapiens (Human) | PR |
| Q5I0I8 | Noc4l | Nucleolar complex protein 4 homolog | Rattus norvegicus (Rat) | PR |
| P41843 | T20B12.3 | Uncharacterized protein T20B12.3 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MERHPASASS | RQELGRLLEA | VLTSRGQANA | VFDILAVLQS | EEPEEIEEGV | RTCSRLFGTL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LEREELFVGS | LPSEDTALAG | SQGATYKYKV | WIRHRYHSCC | NRLEELLAHP | TFQVKELALK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TLMKFVQLEG | AKPLEKPQWE | SHYLFPRTLF | RAVVGGLLTP | EDDHSLLISH | FCEYLEYDDI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RYHTMQVATS | IMARATSQQP | EVSLTLWNNA | FTLLSAVSLP | LQECELTNFY | VKHAQTSDKW |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KVVHLKEHKK | AFQEMWLGFL | KHKLPLSLYK | KVLVAMHDSI | LPHLAQPTLM | IDFLTSACDV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GGAISLLALN | GLFILIHKHN | LEYPDFYQKL | YGLLDPSIFH | VKYRARFFHL | ADLFLSSSHL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PAYLVAAFAK | RLARLALTAP | PEALLMVLPL | ICNLLRRHPA | CRVMVHRPQG | PELDADPYDP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TEKDPARSRA | LESCLWELQT | LQQHYHPEVS | KAASVINQVL | SVPEVSIAPL | LELTAYEIFE |
| 490 | 500 | 510 | |||
| QDLKKKMPES | VPLEFIPAKG | LLGRQDDLCT | QFFCLS |