Q06512

PR
Gene name
NOC4 (UTP19, YPR144C)
Protein name
Nucleolar complex protein 4
Names
U three protein 19, U3 small nucleolar RNA-associated protein 19, U3 snoRNA-associated protein 19
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YPR144C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-111 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

21 structures for Q06512

Entry ID Method Resolution Chain Position Source
5WLC EM 380 A SU 147-513 PDB
6KE6 EM 340 A RO 1-552 PDB
6LQP EM 320 A RO 1-552 PDB
6LQQ EM 410 A RO 1-552 PDB
6LQR EM 860 A RO 1-552 PDB
6LQS EM 380 A RO 1-552 PDB
6LQU EM 370 A RO 1-552 PDB
6LQV EM 480 A RO 1-552 PDB
6ZQA EM 440 A US 1-552 PDB
6ZQB EM 390 A US 1-552 PDB
6ZQC EM 380 A US 1-552 PDB
6ZQD EM 380 A US 1-552 PDB
6ZQE EM 710 A US 1-552 PDB
6ZQF EM 490 A US 1-552 PDB
7AJT EM 460 A US 1-552 PDB
7AJU EM 380 A US 1-552 PDB
7D4I EM 400 A RO 1-552 PDB
7D5S EM 460 A RO 1-552 PDB
7D63 EM 1230 A RO 1-552 PDB
7SUK EM 399 A SU 1-513 PDB
AF-Q06512-F1 Predicted AlphaFoldDB

9 variants for Q06512

Variant ID(s) Position Change Description Diseaes Association Provenance
s16-821249 57 M>I No SGRP
s16-821240 60 F>L No SGRP
s16-821237 61 Q>H No SGRP
s16-820945 159 N>D No SGRP
s16-820924 166 V>F No SGRP
s16-820081 447 D>N No SGRP
s16-819818 534 D>E No SGRP
s16-819811 537 S>G No SGRP
s16-819807 538 E>V No SGRP

No associated diseases with Q06512

1 regional properties for Q06512

Type Name Position InterPro Accession
domain CCAAT-binding factor 317 - 481 IPR005612

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
90S preribosome A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Noc4p-Nop14p complex A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
preribosome, small subunit precursor A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit.
small-subunit processome A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

7 GO annotations of biological process

Name Definition
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable.
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA.
maturation of SSU-rRNA Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule.
ribosomal small subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit.
ribosomal small subunit biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5ZJC7 NOC4L Nucleolar complex protein 4 homolog Gallus gallus (Chicken) PR
Q9BVI4 NOC4L Nucleolar complex protein 4 homolog Homo sapiens (Human) PR
Q8BHY2 Noc4l Nucleolar complex protein 4 homolog Mus musculus (Mouse) PR
Q5I0I8 Noc4l Nucleolar complex protein 4 homolog Rattus norvegicus (Rat) PR
P41843 T20B12.3 Uncharacterized protein T20B12.3 Caenorhabditis elegans PR
10 20 30 40 50 60
MVLLISEIKD IAKRLTAAGD RKQYNSIIKL INELVIPENV TQLEEDETEK NLRFLVMSLF
70 80 90 100 110 120
QIFRKLFSRG DLTLPSSKKS TLEKEQFVNW CRKVYEAFKT KLLAIISDIP FETSLGLDSL
130 140 150 160 170 180
DVYLQLAELE STHFASEKGA PFFPNKTFRK LIIALWSSNM GEIEDVKSSG ASENLIIVEF
190 200 210 220 230 240
TEKYYTKFAD IQYYFQSEFN QLLEDPAYQD LLLKNVGKWL ALVNHDKHCS SVDADLEIFV
250 260 270 280 290 300
PNPPQAIENE SKFKSNFEKN WLSLLNGQLS LQQYKSILLI LHKRIIPHFH TPTKLMDFLT
310 320 330 340 350 360
DSYNLQSSNK NAGVVPILAL NGLFELMKRF NLEYPNFYMK LYQIINPDLM HVKYRARFFR
370 380 390 400 410 420
LMDVFLSSTH LSAHLVASFI KKLARLTLES PPSAIVTVIP FIYNLIRKHP NCMIMLHNPA
430 440 450 460 470 480
FISNPFQTPD QVANLKTLKE NYVDPFDVHE SDPELTHALD SSLWELASLM EHYHPNVATL
490 500 510 520 530 540
AKIFAQPFKK LSYNMEDFLD WNYDSLLNAE SSRKLKTLPT LEFEAFTNVF DNEDGDSEAS
550
SQGNVYLPGV AW